The use of autologous platelet rich plasma gel in bulbar and penile buccal mucosa urethroplasty: Preliminary report of our first series

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Marcello Scarcia *
Francesco Paolo Maselli
Giuseppe Cardo
Giuseppe Mario Ludovico
(*) Corresponding Author:
Marcello Scarcia | scarciam@hotmail.com

Abstract

Objective: The Buccal Mucosa (BM) UrethroPlasty (UP) is one of the preferred treatments for long or compli-cated urethral strictures. We propose the use of autologous Platelet Rich Plasma gel (aPRPg) in order to enhance to vascularization of BM graft and reduce the fibrous spongy. We report the outcome of our ten cases of bulbar and penile UP and the safety of this technique. Materials and metods: Ten patients underwent to BM UP with use of aPRP gel. Median age was 46. Stricture etiology was idiopathic, failed hypospadias and flogistic. Average stricture length was 3.7 cm. All patient were preoperatively evaluated with uroflowmetry , retrograde urethrography, cystoscopy and questionnaire. The harvesting of the aPRP was performed in blood bank from peripheral venous sample. Catheter was usually removed after 3 weeks and urethrography was performed after 6 weeks. Results: All patients reported no problem on the donor site. At time of follow-up (median 20 month, 12-34) all patients refer no problem and a good uroflowmetry. No re-strictures at the anastomotic sites were demonstrated in any of the patients. Conclusion: However in our experience the follow-up is limited and no definitive conclusion or comparison can be made with the original BM UP. The use of aPRP gel seems feasible and safe. In our opinion it is important to continue investigating this procedure for its advantages in case of complex urethral strictures complicated by fibrous spongy, above all in penile urethral strictures post hypospadia repair.

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Author Biographies

Marcello Scarcia, Urology Department “F. Miulli”, General Hospital Acquaviva delle Fonti, Bari

Department of Urology, Mininvasive Surgery

Francesco Paolo Maselli, Urology Department “F. Miulli”, General Hospital Acquaviva delle Fonti, Bari

Department of Urology, Mininvasive Surgery

Giuseppe Cardo, Urology Department “F. Miulli”, General Hospital Acquaviva delle Fonti, Bari

Department of Urology, Mininvasive Surgery

Giuseppe Mario Ludovico, Urology Department “F. Miulli”, General Hospital Acquaviva delle Fonti, Bari

Department of Urology, Mininvasive Surgery