Clinical significance of prostatic-urethral angulation on the treatment outcome of patients with symptomatic benign prostatic hyperplasia treated with tamsulosin hydrochloride

  • Hassan El-Tatawy Urology Department, Tanta University Hospital, Egypt.
  • Tarek Gameel Urology Department, Tanta University Hospital, Egypt.
  • Mohammed Abo El-enen Urology Department, Tanta University Hospital, Egypt.
  • Ayman Hagras Urology Department, Tanta University Hospital, Egypt.
  • Ayman Mousa Urology Department, Tanta University Hospital, Egypt.
  • Abdel Hamid El-Bahnasy Urology Department, Tanta University Hospital, Egypt.
  • Ali Abdel Raheem | aliraheem82@yahoo.com Urology Department, Tanta University Hospital, Egypt.
  • Khaled Abu-dewan Radiology Department, Tanta University Hospital, Egypt.

Abstract

Objectives: To evaluate the impact of the prostatic-urethral angulation (PUA) on the treatment efficacy of selective alpha-1A receptor blocker in male patients with lower urinary tract symptoms secondary to benign prostatic hyperplasia (LUTS/BPH). Materials and methods: A total of 80 patients with LUTS/BPH and with mean age 53.3 ± 6.3 (range 47-70) were included in our prospective comparative study. The patients were classified into 2 groups as a consecutive cases 40 in each one depending on the PUA either ≤ 35° (group A) or > 35° (group B). PUA and different prostatic parameters were measured using transrectal ultrasound. Prostate-specific antigen (PSA), the International Prostate Symptom Score and quality of life score (IPSS/QoL score), maximum flow rate (Qmax), and postvoid residual (PVR) volume were compared between the groups. The clinical significance of PUA was evaluated after 8 weeks of medical treatment with tamsulosin hydrochloride 0.4 mg daily. Results: Baseline evaluation (pre-treatment) for both groups were comparable to each other with no clinically significant difference regarding age, PSA, IPSS/QoL score, Qmax and PVR volume (P-value > 0.05). Comparison of parameters after 8 weeks showed that tamsulosin hydrochloride improved the total IPSS and all subscores (P < 0.001), QoL (P = 0.001), Qmax (P = 0.002), and PVR (P = 0.04) in group A (Table 1). Conclusion: Tamsulosin hydrochloride appears to be less effective in improving IPSS/Qol score, Qmax and PVR in patients with lager PUA. The PUA might be a predictor for the treatment efficacy of α-blockers and more studies are warranted in the future before the final conclusion.

Dimensions

Altmetric

PlumX Metrics

Downloads

Download data is not yet available.
Published
2015-09-30
Info
Issue
Section
Original Papers - Prostate
Keywords:
Prostatic-urethral angulation, benign prostatic hyperplasia and tamsulosin hydrochloride
Statistics
  • Abstract views: 1282

  • PDF: 619
How to Cite
El-Tatawy, H., Gameel, T., El-enen, M., Hagras, A., Mousa, A., El-Bahnasy, A., Raheem, A., & Abu-dewan, K. (2015). Clinical significance of prostatic-urethral angulation on the treatment outcome of patients with symptomatic benign prostatic hyperplasia treated with tamsulosin hydrochloride. Archivio Italiano Di Urologia E Andrologia, 87(3), 238-242. https://doi.org/10.4081/aiua.2015.3.238

Most read articles by the same author(s)