The histology and the proapoptotic control in the ipsilateral and the contralateral testes following unilateral vasectomy

  • Aydin Ismet Hazar Taksim Training and Research Hospital, Department of Urology Istanbul, Turkey.
  • Basri Cakiroglu | drbasri@hotmail.com Hisar Intercontinental Hospital, Department of Urology Istanbul, Turkey.
  • Ertan Sakalli Zonguldak State Hospital, Department of Urology, Zonguldak, Turkey.
  • Mustafa Bahadir Can Balci Taksim Training and Research Hospital, Department of Urology Istanbul, Turkey.
  • Erkan Eyyupoglu Amasya Training and Research Hospital, Department of Urology, Amasya, Turkey.
  • Tuncay Tas Taksim Training and Research Hospital, Department of Urology Istanbul, Turkey.
  • Orhun Sinanoglu Maltepe University Medical School, Department of Urology, Istanbul, Turkey.
  • Pinar Tuzlali Taksim Training and Research Hospital, Department of Pathology, Istanbul, Turkey.
  • Nusret Can Cilesiz Taksim Training and Research Hospital, Department of Urology Istanbul, Turkey.

Abstract

Objective: The aim of this study was to enlighten both the testicular histology and the genetic aspects of the apoptotic process. Thus an experimental study was designed with a model of unilateral vasectomy. Methods: Twenty-two adult male rats were used and 4 main groups were formed. The first (A), the second (B), the third (C), and the fourth group (D) consisted of 4, 4, 4 and 10 rats respectively. Rats in group A had sham operation while rats in other groups (B, C, D) underwent left vasectomy operation including binding of ductus deferens with a 3/0 silk and cutting a minimum of 1 cm part while preserving the vascular structure under 9x magnification. Rats undergoing unilateral vasectomy were sacrificed at the 1st, 2nd and 8th weeks and their testicular structure and proapoptotic gene proteins were compared with that of the control group undergoing sham operation. Results: We found that vasectomy gradually caused destruction and both ipsilateral and contralateral testicles were affected showing initial apoptosis. Conclusion: The procedure causes destruction in the testicular structure by causing bilateral intratubular germ cell necrosis, unilateral obstruction, increase in the tubular pressure and processes that are aggravated by some probable autoimmune reactions.

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Published
2015-09-30
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Section
Original Papers - Andrology
Keywords:
Testis, Spermatogenesis, Vasectomy, Apoptosis, BCL-2 protein
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How to Cite
Hazar, A. I., Cakiroglu, B., Sakalli, E., Balci, M. B. C., Eyyupoglu, E., Tas, T., Sinanoglu, O., Tuzlali, P., & Cilesiz, N. C. (2015). The histology and the proapoptotic control in the ipsilateral and the contralateral testes following unilateral vasectomy. Archivio Italiano Di Urologia E Andrologia, 87(3), 198-203. https://doi.org/10.4081/aiua.2015.3.198

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