Improvement of seminal quality and sexual function of men with oligoasthenoteratozoospermia syndrome following supplementation with L-arginine and Pycnogenol®


Submitted: September 28, 2015
Accepted: September 28, 2015
Published: September 30, 2015
Abstract Views: 9759
PDF: 3860
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Authors

  • Yoshitomo Kobori Department of Urology, Dokkyo Medical University Koshigaya Hospital, Saitama, Japan.
  • Keisuke Suzuki Department of Urology, Dokkyo Medical University Koshigaya Hospital, Saitama, Japan.
  • Toshiyuki Iwahata Department of Urology, Dokkyo Medical University Koshigaya Hospital, Saitama, Japan.
  • Takeshi Shin Department of Urology, Dokkyo Medical University Koshigaya Hospital, Saitama, Japan.
  • Yuko Sadaoka Department of Urology, Dokkyo Medical University Koshigaya Hospital, Saitama, Japan.
  • Ryo Sato Department of Urology, Dokkyo Medical University Koshigaya Hospital, Saitama, Japan.
  • Kojiro Nishio Department of Urology, Dokkyo Medical University Koshigaya Hospital, Saitama, Japan.
  • Hiroshi Yagi Department of Urology, Dokkyo Medical University Koshigaya Hospital, Saitama, Japan.
  • Gaku Arai Department of Urology, Dokkyo Medical University Koshigaya Hospital, Saitama, Japan.
  • Shigehiro Soh Department of Urology, Dokkyo Medical University Koshigaya Hospital, Saitama, Japan.
  • Hiroshi Okada Department of Urology, Dokkyo Medical University Koshigaya Hospital, Saitama, Japan.
  • Jeffry Michael Strong Horphag Research, Cointrin/Geneva, Switzerland.
  • Peter Rohdewald Institute of Pharmaceutical Chemistry, University of Munster, Munster, Germany.
We evaluated the effectiveness of antioxidant co-supplementation therapy using Larginine and Pycnogenol® in Japanese men with oligoasthenozoospermia and mild erectile dysfunction (ED). A total of forty-seven adult males with oligoasthenoteratozoospermia syndrome (OAT) were eligible for enrollment. The effectiveness of supplementation with a combination of L-arginine 690 mg and French maritime pine bark extract (Pycnogenol®) 60mg for OAT and ED was investigated. The sperm concentration was enhanced significantly after treatment 2 and 4 months (11.79 ± 9.86 to 21.22 ± 28.17 and 20.15 ± 23.99 × 106/ml). Significant improvements in the International Index of Erectile Function (IIEF) were observed in the total score of IIEF (57.69 ± 11.04 to 59.43 ± 12.57) and domain of Orgasmic Function (9.01 ± 1.92 to 9.34 ± 1.66) after 4 months of treatment. L-arginine acts to increase the production of nitric oxide and Pycnogenol® activates the endothelial nitric oxide synthase and it is a potent antioxidant and inhibitor of inducible nitric oxide synthase. This study suggests that the combination of Pycnogenol® and L-arginine (Edicare®) is helpful for infertile men to ameliorate simultaneously quality of sperms as well as erectile functions.

Kobori, Y., Suzuki, K., Iwahata, T., Shin, T., Sadaoka, Y., Sato, R., Nishio, K., Yagi, H., Arai, G., Soh, S., Okada, H., Strong, J. M., & Rohdewald, P. (2015). Improvement of seminal quality and sexual function of men with oligoasthenoteratozoospermia syndrome following supplementation with L-arginine and Pycnogenol®. Archivio Italiano Di Urologia E Andrologia, 87(3), 190–193. https://doi.org/10.4081/aiua.2015.3.190

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