In-vitro effects of PDE5 inhibitor and statin treatment on the contractile responses of experimental MetS rabbit's cavernous smooth muscle

  • Yasin Erden Cumhuriyet University School of Medicine Department of Urology, Turkey.
  • Esat Korgalı | estkorgali@hotmail.com Cumhuriyet University School of Medicine Department of Urology, Turkey.
  • Gokce Dundar Cumhuriyet University School of Medicine Department of Urology, Turkey.
  • Semih Ayan Cumhuriyet University School of Medicine Department of Urology, Turkey.
  • Gökhan Gokce Cumhuriyet University School of Medicine Department of Urology, Turkey.
  • Sahin Yildirim Cumhuriyet University School of Medicine Department of Pharmachology, Turkey.
  • Emin Yener Gultekin Cumhuriyet University School of Medicine Department of Urology, Turkey.

Abstract

Objective: Hypercholesterolaemia promotes erectile dysfunction through increased superoxide formation and decreased nitric oxide bioactivity in cavernosal tissue. The role of nitric oxide on erectile function is well known. Statins have lipid lowering properties and can modulate endothelial nitric oxide bioavailability. Sildenafil, enhances smooth muscle relaxation in corpus cavernosum. We invastigated in-vitro effects of sildenafil and rosuvastatin on nonadrenergic, non-cholinergic and nitric oxide mediated cavernosal smooth musle relaxation in metabolic syndrome rabbits, since alterations in this pathway are recognised in diabetic and hypercholesterolemic erectile dysfunction. Methods: Ten male rabbits were fed a standart diet as control group, fourty male rabbits were fed a hypercholesterolemic diet for 12 weeks. Hypercholesterolemic group were divided for without treatment, rosuvastatin treatment, sildenafil teratment, and rosuvastatin + sildenafil treatment (N = 10 per groups). Results: Serum levels of cholesterol and glucose were significantly higher in the experimental group than in the control group (p < 0.05). After theraphy no differences were found among the groups in relaxation responses to sodium nitroprusside. The relaxation responses to carbachol and EFS were significantly reduced in metabolic syndrome group to control group (p < 0.05), but there were no differences between the other groups and control group. There was a significantly lower in-vitro relaxation response in the metabolic syndrome rabbits than in controls and the others (p < 0.05). Conclusion: Both agents improve in-vitro relaxation responses of erectile tissue from metabolic syndrome rabbits to endothelial non-adrenergic, non-cholinergic and nitric oxide. This finding supports to the results of other clinical studies with these drugs.

Dimensions

Altmetric

PlumX Metrics

Downloads

Download data is not yet available.
Published
2014-03-28
Info
Issue
Section
Original Papers - Andrology
Keywords:
Erectile dysfunction, Metabolic syndrome, Sildenafil, Rosuvastatin
Statistics
  • Abstract views: 1442

  • PDF: 1435
How to Cite
Erden, Y., Korgalı, E., Dundar, G., Ayan, S., Gokce, G., Yildirim, S., & Gultekin, E. (2014). In-vitro effects of PDE5 inhibitor and statin treatment on the contractile responses of experimental MetS rabbit’s cavernous smooth muscle. Archivio Italiano Di Urologia E Andrologia, 86(1), 33-38. https://doi.org/10.4081/aiua.2014.1.33