https://doi.org/10.4081/aiua.2021.3.280
The presence of chronic inflammation in positive prostate biopsy is associated with upgrading in radical prostatectomy
Submitted: March 16, 2021
Accepted: May 7, 2021
Published: September 30, 2021
Accepted: May 7, 2021
Abstract Views: 1015
PDF: 477
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All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Authors
Objective: This study aimed to determine the predictive effect of the presence of chronic prostatitis associated with prostate cancer (PCa) in prostate biopsy on Gleason score upgrade (GSU) in radical prostatectomy (RP) specimens.
Materials and methods: The data of 295 patients who underwent open or robotic RP with a diagnosis of localized PCa following biopsy were retrospectively analyzed. Patients were divided into two groups with and without GSU following RP. Predictive factors affecting GSU on biopsy were determined. The impact of chronic prostatitis associated with prostate cancer on GSU was examined via logistic regression analysis.
Results: Out of 224 patients with Gleason 3+3 scores on biopsy, 145 (64.7%) had Gleason upgrade, and 79 (35.2%) had no upgrade. Whilst comparing the two groups with and without Gleason upgrade in terms of patient age, prostate-specific antigen (PSA) value, PSA density (PSAD), prostate volume (PV), neutrophil/lymphocyte (N/L) ratio, number of positive cores, percentage of positive cores, and Prostate Imaging Reporting and Data System version 2 score, no statistically significant difference was detected. The presence of chronic prostatitis associated with PCa was higher in the patient cohort with GSU in contrast to the other group (p < 0.001). According to the univariate logistic regression analysis, the presence of chronic prostatitis was identified to be an independent marker for GSU.
Conclusions: Pathologists and urologists should be careful regarding the possibility of a more aggressive tumor in the presence of chronic inflammation associated with PCa because inflammation within PCa was revealed to be linked with GSU after RP.
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How to Cite
Guner, E., Danacioglu, Y. O., Arikan, Y., Seker, K. G. ., Polat, S., Baytekin, H. F., & Simsek, A. (2021). The presence of chronic inflammation in positive prostate biopsy is associated with upgrading in radical prostatectomy. Archivio Italiano Di Urologia E Andrologia, 93(3), 280–284. https://doi.org/10.4081/aiua.2021.3.280
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