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History of infantile BCG immunization did not predict lamina propria invasion and/or high-grade in patients with non-muscle invasive bladder cancer

Authors

Anastasia MacDonald
https://orcid.org/0009-0006-4756-3742
Northern Ontario School of Medicine, Thunder Bay, ON, Canada.
Vahid Mehrnoush
Northern Ontario School of Medicine, Thunder Bay, ON, Canada.
Asmaa Ismail
Northern Ontario School of Medicine, Thunder Bay, ON, Canada.
Livio Di Matteo
Department of Economics, Lakehead University, Thunder Bay, ON, Canada.
Ahmed Zakaria
https://orcid.org/0000-0002-4582-9969
Northern Ontario School of Medicine, Thunder Bay, ON, Canada.
Waleed Shabana
Northern Ontario School of Medicine, Thunder Bay, ON, Canada.
Ashraf Shaban
https://orcid.org/0009-0003-6647-0136
Northern Ontario School of Medicine, Thunder Bay, ON, Canada.
Mohammed Bassuony
Northern Ontario School of Medicine, Thunder Bay, ON, Canada.
Hazem Elmansy
Northern Ontario School of Medicine, Thunder Bay, ON, Canada.
Walid Shahrour
Northern Ontario School of Medicine, Thunder Bay, ON, Canada.
Owen Prowse
Northern Ontario School of Medicine, Thunder Bay, ON, Canada.
Ahmed Kotb
drahmedfali@gmail.com
https://orcid.org/0000-0002-1484-1332
Northern Ontario School of Medicine, Thunder Bay, ON, Canada.

Objective: To evaluate the utility of infantile BCG vaccination history in predicting stage and grade of tumours in non-muscle invasive bladder cancer (NMIBC). Materials and methods: We retrospectively analyzed data from patients from a single center who were diagnosed with new NMIBC and underwent transurethral resection of bladder tumour (TURBT) between 2017 and 2022. We assessed BCG immunization status with various demographics and comorbidities, as well as tumour recurrence, progression, stage, and grade. Results: A total of 188 patients met the inclusion criteria for our study. The mean age of patients at the time of diagnosis was significantly lower in those that had been immunized with BCG (71 ± 9) than those who had not (77 ± 10) (p < 0.0001). History of BCG immunization did not correlate with sex, history of diabetes mellitus (DM), prior history of intravesical BCG treatment, and tumour recurrence, progression, stage, and grade. Conclusions: History of infantile BCG vaccination did not correlate with the depth of invasion and/or the grade in patients with non-muscle invasive bladder cancer. Patients that received infantile BCG vaccination were significantly younger at the time of diagnosis of NMIBC.

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Rosario Leonardi, Francesca Ambrosini, Angelo Cafarelli, Alessandro Calarco, Renzo Colombo, Domenico Tuzzolo, Ferdinando De Marco, Giovanni Ferrari, Giuseppe Ludovico, Stefano Pecoraro, Ottavio De Cobelli, Carlo Terrone, Guglielmo Mantica (2024)
Office-based management of Non-Muscle Invasive Bladder Cancer (NMIBC): A position paper on current state of the art and future perspectives. Archivio Italiano di Urologia e Andrologia, 96(1),
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How to Cite

MacDonald, A., Mehrnoush, V., Ismail, A., Di Matteo, L., Zakaria, A., Shabana, W., Shaban, A., Bassuony, M., Elmansy, H., Shahrour, W., Prowse, O., & Kotb, A. (2023). History of infantile BCG immunization did not predict lamina propria invasion and/or high-grade in patients with non-muscle invasive bladder cancer. Archivio Italiano Di Urologia E Andrologia, 95(2). https://doi.org/10.4081/aiua.2023.11380
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