https://doi.org/10.4081/aiua.2022.4.443

Urinary epidermal growth factor and monocyte chemotactic protein-1 as biomarkers of renal injury in patients with obstructed nephropathy

Vol. 94 No. 4 (2022)
Submitted: October 27, 2022
Accepted: November 12, 2022
Published: December 27, 2022
Upper urinary tract obstruction, Urinary monocyte chemotactic protein-1 (uMCP-1), Urinary epidermal growth factor (uEGF)
Abstract Views: 526
PDF: 240
Publisher's note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.

Authors

Eman M. El-Dydamony
Emanmohamed.8@azhar.edu.eg
Department of Urology, Faculty of Medicine (for Girls), Al-Azhar University, Cairo, Egypt.
Mohamed Ahmad Abdelaal
Department of Urology, Faculty of Medicine (for Girls), Al-Azhar University, Cairo, Egypt.
Sammar Ahmad Kasim
Department of Internal medicine, Faculty of Medicine (for Girls), Al-Azhar University, Cairo, Egypt.
Doaa Refaat Ameen
Department of Biochemistry, Faculty of Medicine (for Girls), Al-Azhar University, Cairo, Egypt.
Doaa Aly Abd El-Fattah
Department of Clinical Pathology, Faculty of Medicine (for Girls), Al-Azhar University, Cairo, Egypt.

Objective: To evaluate the role of urinary Monocyte Chemotactic Protein-1 (MCP1) and urinary epidermal growth factor (EGF) in diagnosing of upper urinary tract obstruction (UUTO).
Patient and methods: Over a period of 6 months (January 2022 to June 2022) this prospective case control comparative study was conducted on 120 participants, 60 of them with UUTO and 60 healthy controls. A morning urine sample of all participants was tested for EGF and MCP-1. after taking a detailed history taking and laboratory and radiological evaluation.
Results: Urinary MCP-1(uMCP-1) was significantly (p-value = 0.000) increased in UUTO group showing a mean ± SD of 518.10 ± 51.19 ng/L compared to a mean ± SD of 143.32 ± 58.03 ng/L in the controls, whereas a significantly (p-value = 0.000) decrease of urinary EGF (uEGF) was observed in patients with UUTO compared to control group. A significant difference of uEGF level and uEGF/uMCP1 ratio was observed between mild compared to moderate/severe UUTO.
Conclusions: Utilization of the urinary biomarker MCP1, EGF and uEGF/uMCP1 ratio in patients with UUTO can adequately be used as a simple, efficacious and noninvasive way in diagnosis of UUTO.

Dimensions

Altmetric

PlumX Metrics

Downloads

Download data is not yet available.

Citations

Crossref
Scopus
Google Scholar
Europe PMC
Mesrobian, H.-G.O.; Mitchell, M.E.; See, W.A.; Halligan, B.D.; Carlson, B.E.; Greene, A.S.; Wakim, B.T. Candidate Urinary Biomarker Discovery in Ureteropelvic Junction Obstruction: A Proteomic Approach. J. Urol. 2010, 184, 709–714. DOI: https://doi.org/10.1016/j.juro.2010.03.061
Seifriedova Z, Flogelova H, Sarapatka J, Smakal O, Student V. The use of biomarkers in the diagnosis and treatment of obstruction of the upper urinary tract in children. Biomedical Papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia. 2022 Feb 11. DOI: https://doi.org/10.5507/bp.2022.002
Downing G. Biomarkers definitions working group. Biomarkers and surrogate endpoints. Clin Pharmacol Ther. 2001;69:89-95. DOI: https://doi.org/10.1067/mcp.2001.113989
Boonstra J. Growth factor-induced signal transduction in adherent mammalian cells is sensitive to gravity. FASEB J 1999;13:S35-42. DOI: https://doi.org/10.1096/fasebj.13.9001.s35
Breyer JA, Cohen S. The epidermal growth factor precursor isolated from murine kidney membranes (chemical characterization and biological properties). J Biol Chem 1990; 265:16564-70. DOI: https://doi.org/10.1016/S0021-9258(17)46260-0
Harris RC. Potential physiologic roles for epidermal growth factor in the kidney. Am J Kidney Dis 1991;17: 627-30. DOI: https://doi.org/10.1016/S0272-6386(12)80336-2
Moledina, D.G.; Isguven, S.; McArthur, E.; Thiessen-Philbrook, H.; Garg, A.X.; Shlipak, M.; Whitlock, R.; Kavsak, P.A.; Coca, S.G.; Parikh, C.R.; et al. Plasma Monocyte Chemotactic Protein-1 Is Associated With Acute Kidney Injury and Death After Cardiac Operations. Ann. Thorac. Surg. 2017, 104, 613–620. DOI: https://doi.org/10.1016/j.athoracsur.2016.11.036
Yu L, Zhou L, Li Q, Wu B, Brooks JD, Sun H. J Elevated urinary lipocalin-2, interleukin-6 and monocyte chemoattractant protein-1 levels in children with congenital ureteropelvic junction obstruction Pediatr Urol 2019;15:44.e1-7. DOI: https://doi.org/10.1016/j.jpurol.2018.10.007
Karakus S, Oktar T, Kucukgergin C, Kalelioglu I, Seckin S, Atar A, Ander H, Ziylan O. Urinary IP- 10, MCP-1, NGAL, cystatin-C, and KIM-1 levels in prenatally diagnosed unilateral hydronephrosis: the search for an ideal biomarker. Urology 2016; 87:185-92. DOI: https://doi.org/10.1016/j.urology.2015.09.007
Grandaliano, G.; Gesualdo, L.; Ranieri, E.; Monno, R.; Montinaro, V.; Marra, F.; Schena, F.P. Monocyte chemotactic peptide-1 expression in acute and chronic human nephritides: A pathogenetic role in interstitial monocytes recruitment. J. Am. Soc. Nephrol. 1996, 7, 906–913. DOI: https://doi.org/10.1681/ASN.V76906
Grandaliano, G.; Gesualdo, L.; Bartoli, F.; Ranieri, E.; Monno, R.; Leggio, A.; Paradies, G.; Caldarulo, E.; Infante, B.; Schena, F.P. MCP-1 and EGF renal expression and urine excretion in human congenital obstructive
nephropathy. Kidney Int. 2000, 58, 182–192. DOI: https://doi.org/10.1046/j.1523-1755.2000.00153.x
Lucarelli G, Mancini V, Galleggiante V, et al. Emerging urinary markers of renal injury in obstructive nephropathy. Biomed Res Int. 2014: 303298. DOI: https://doi.org/10.1155/2014/303298
Shokeir AA. The diagnosis of upper urinary tract obstruction. Br J Urol 1999;83:893-901 DOI: https://doi.org/10.1046/j.1464-410x.1999.00118.x
Palmer LS, Maizels M, Kaplan WE, Firlit CF, Cheng EY. Urine levels of transforming growth factor-beta-l in children with ureteropelvic junction obstruction. Urology 1997;50:769-73. DOI: https://doi.org/10.1016/S0090-4295(97)00331-2
Madsen MG, Nørregaard R, Palmfeldt J, Olsen LH, Frøkiær J, Jørgensen TM. Epidermal growth factor and monocyte chemotactic peptide-1: potential biomarkers of urinary tract obstruction in children with hydronephrosis. Journal of pediatric urology. 2013 Dec 1;9(6):838-45. DOI: https://doi.org/10.1016/j.jpurol.2012.11.011
Lin SY, Makino K, Xia W et al. Nuclear localization of EGF receptor and its potential new role as a transcription factor. Nat Cell Biol 2001; 3: 802–8 DOI: https://doi.org/10.1038/ncb0901-802
Taranta-Janusz K, Wasilewska A, Dębek W, Waszkiewicz- Stojda M (2012) Urinary cytokine profiles in unilateral congenital hydronephrosis. Pediatr Nephrol 27:2107–2113. DOI: https://doi.org/10.1007/s00467-012-2230-9
Yi Yang , Xin Zhou, Hong Gao, Shi Jun Ji, Changlin Wang. The expression of epidermal growth factor and transforming growth factor-beta1 in the stenotic tissue of congenital pelvi-ureteric junction obstruction in children J Pediatr Surg. 2003 Nov;38(11):1656-60. DOI: https://doi.org/10.1016/S0022-3468(03)00577-3

How to Cite

El-Dydamony, E. M., Abdelaal, M. A., Kasim, S. A., Ameen, D. R., & El-Fattah, D. A. A. (2022). Urinary epidermal growth factor and monocyte chemotactic protein-1 as biomarkers of renal injury in patients with obstructed nephropathy. Archivio Italiano Di Urologia E Andrologia, 94(4), 443–446. https://doi.org/10.4081/aiua.2022.4.443
Copyright (c) 2022 the Author(s) Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

PAGEPress has chosen to apply the Creative Commons Attribution NonCommercial 4.0 International License (CC BY-NC 4.0) to all manuscripts to be published.