https://doi.org/10.4081/aiua.2021.4.465
0
0
0
0
Smart Citations
0
0
0
0
Citing PublicationsSupportingMentioningContrasting
View Citations

See how this article has been cited at scite.ai

scite shows how a scientific paper has been cited by providing the context of the citation, a classification describing whether it supports, mentions, or contrasts the cited claim, and a label indicating in which section the citation was made.

The effect of N-acetyl cysteine consumption on men with abnormal sperm parameters due to positive history of COVID-19 in the last three months

Authors

Bahare Rafiee
medicalarticle2020@yahoo.com
Department of Reproductive Biology, School of Advanced medical Sciences and Applied Technologies, Shiraz, Iran, Islamic Republic of.
Seyed Mohammad Bagher Tabei
Genetics Department, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran, Islamic Republic of.

Male infertility is an important factor accounting for 40-50% of infertility cases that may be due to disturbance in one of the parameters as concentration, motility and morphology observed in one or two semen analysis with an interval of 1 and 4 weeks. COVID-19 may affect male fertility through virus division, cytotoxic effects on testicular tissue and immunopathological effect. N-acetyl cysteine (NAC) improved sperm concentration and acrosome reaction while reducing reactive oxygen species (ROS) and oxidation of sperm DNA. This interventional study was conducted on 200 men who were referred to private infertility clinics for female factor (their previous semen analysis was normal) and got COVID-19 infection in the last 3 months showing an impairment of the latest semen analysis due to COVID. Men were placed in two groups of control (n = 100) and intervention (NAC consumption). Subjects who got COVID-19 infection had a significant impairment of sperm quality (sperm concentration, sperm motility, and normal sperm morphology) compared to their semen analysis evaluated before the COVID-19 infection. NAC consumption significantly improved sperm total motility, sperm morphology and sperm concentration. COVID-19 infection has a negative effect on sperm parameters. NAC supplementation may have positive effect on sperm parameters.

Dimensions

Altmetric

Article has an altmetric score of 6

PlumX Metrics

Plum Print visual indicator of research metrics
  • Citations
    • Citation Indexes: 13
  • Captures
    • Readers: 24
see details

Downloads

Citations

Crossref
Scopus
Google Scholar
Europe PMC
Zegers-Hochschild F, Adamson GD, de Mouzon J, et al. International committee for monitoring assisted reproductive technology (ICMART) and the world health organization (WHO) revised glossary of ART terminology. Fertil Steril. 2009; 92:1520-4. DOI: https://doi.org/10.1016/j.fertnstert.2009.09.009
Rutstein SO, Shah IH. 2004. Infecundity, Infertility, and Childlessness in Developing Countries. DHS Comparative Reports No. 9. Calverton, Maryland, USA: ORC Macro and the World Health Organization.
Lotti F, Maggi M. Ultrasound of the male genital tract in relation to male reproductive health. Hum Reprod Update. 2015; 21:56-83. DOI: https://doi.org/10.1093/humupd/dmu042
World Health Organization. WHO Laboratory Manual for the Examination of Human Semen and Semen-Cervical Mucus Interaction, 6th ed., Cambridge University Press, Cambridge 2021, pp. 1-86.
Butt F, Akram N. Semen analysis parameters: Experiences and insight into male infertility at a tertiary care hospital in Punjab. J Pak Med Assoc. 2013; 63:558-62.
Aitken RJ. COVID-19 and human spermatozoa-potential risks for infertility and sexual transmission? Andrology. 2021; 9:48-52. DOI: https://doi.org/10.1111/andr.12859
Verma S, Saksena S, Sadri-Ardekani H. ACE2 receptor expression in testes: implications in coronavirus disease 2019 pathogenesis. Biol Reprod. 2020; 103:449-451. DOI: https://doi.org/10.1093/biolre/ioaa080
Li LJ, Zhang FB, Liu SY, et al. Human sperm devoid of germinal angiotensin-converting enzyme is responsible for total fertilization failure and lower fertilization rates by conventional in vitro fertilization. Biol Reprod. 2014; 90:125. DOI: https://doi.org/10.1095/biolreprod.113.114827
Nikolaeva MA, Balyasnikova IV, Alexinskaya MA, et al. Testicular isoform of angiotensin I-converting enzyme (ACE, CD143) on the surface of human spermatozoa: revelation and quantification using monoclonal antibodies. Am J Reprod Immunol. 2006; 55:54-68. DOI: https://doi.org/10.1111/j.1600-0897.2005.00326.x
Foresta C, Mioni R, Rossato M, et al. Evidence for the involvement of sperm angiotensin converting enzyme in fertilization. Int J Androl. 1991; 14:333-9. DOI: https://doi.org/10.1111/j.1365-2605.1991.tb01101.x
Zafarullah M, Li W, Sylvester J, Ahmad M. Molecular mechanisms of N-acetylcysteine actions. Cell Mol Life Sci. 2003; 60:6-20. DOI: https://doi.org/10.1007/s000180300001
Ciftci H, Verit A, Savas M, et al. Effects of N-acetylcysteine on semen parameters and oxidative/antioxidant status. Urology. 2009;74:73-6.
Safarinejad MR, Safarinejad S. Efficacy of selenium and/or Nacetylcysteine for improving semen parameters in infertile men: a double-blind, placebo controlled, randomized study. J Urol. 2009;181:741-51. DOI: https://doi.org/10.1016/j.juro.2008.10.015
Comhaire F, Christophe A, Zalata A, et al. The effects of combined conventional treatment, oral antioxidants and essential fatty acids on sperm biology in subfertile men. Prostaglandins Leukot Essent Fatty Acids. 2000; 63:159-65. DOI: https://doi.org/10.1054/plef.2000.0174
Holtmann N, Edimiris P, Andree M, et al. Assessment of SARSCoV-2 in human semen-a cohort study. Fertil Steril. 2020; 114:233-8. DOI: https://doi.org/10.1016/j.fertnstert.2020.05.028
Ciftci H, Verit A, Savas M, et al. Effects of N-acetylcysteine on semen parameters and oxidative/antioxidant status. Urology. 2009;74:73-6.
Gorbalenya AE, Baker SC, Baric RS, et al. The species Severe acute respiratory syndrome-related coronavirus: Classifying 2019-nCoV and naming it SARS-CoV-2. Nat. Microbiol. 2020; 5:536-544. DOI: https://doi.org/10.1038/s41564-020-0695-z
Hoffmann M, Kleine-Weber H, Schroeder S, et al. SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor. Cell. 2020; 181:271-280.e8. DOI: https://doi.org/10.1016/j.cell.2020.02.052
Puig-Domingo M, Marazuela M, Giustina A. COVID-19 and endocrine diseases. A statement from the European Society of Endocrinology. Endocrine. 2020; 68:2-5. DOI: https://doi.org/10.1007/s12020-020-02294-5
Delle Fave RF, Polisini G, Giglioni G, et al. COVID-19 and male fertility: Taking stock of one year after the outbreak began. Arch Ital Urol Androl. 2021; 93:115-119. DOI: https://doi.org/10.4081/aiua.2021.1.115
Rodriguez Bustos H, Bravo Maturana G, Cortés-Chau F, et al. Effects of COVID-19 on male sex function and its potential sexual transmission. Arch Ital Urol Androl. 2021; 93:48-52. DOI: https://doi.org/10.4081/aiua.2021.1.48
Paoli D, Pallotti F, Colangelo S, et al. Study of SARS-CoV-2 in semen and urine samples of a volunteer with positive naso-pharyngeal swab. J Endocrinol Invest. 2020; 43:1819-1822. DOI: https://doi.org/10.1007/s40618-020-01261-1
Pan F, Xiao X, Guo J, et al. No evidence of severe acute respiratory syndrome-coronavirus 2 in semen of males recovering from coronavirus disease 2019. Fertil Steril. 2020; 113:1135-1139. DOI: https://doi.org/10.1016/j.fertnstert.2020.04.024
Kayaaslan B, Korukluoglu G, Hasanoglu I, et al. Investigation of SARS-CoV-2 in semen of patients in the acute stage of COVID-19 infection. Urol Int. 2020; 104:678-683. DOI: https://doi.org/10.1159/000510531
Ciftci H, Verit A, Savas M, et al. Effects of Nacetylcysteine on semen parameters and oxidative/antioxidant status. Urology. 2009; 74:73-76. DOI: https://doi.org/10.1016/j.urology.2009.02.034

How to Cite

Rafiee, B. ., & Bagher Tabei, S. M. . (2021). The effect of N-acetyl cysteine consumption on men with abnormal sperm parameters due to positive history of COVID-19 in the last three months. Archivio Italiano Di Urologia E Andrologia, 93(4), 465–467. https://doi.org/10.4081/aiua.2021.4.465

PAGEPress has chosen to apply the Creative Commons Attribution NonCommercial 4.0 International License (CC BY-NC 4.0) to all manuscripts to be published.


Similar Articles

1 2 3 > >> 

You may also start an advanced similarity search for this article.