https://doi.org/10.4081/hls.2024.13031
Preventive effect of yacon leaves capsule in reducing symptoms of Exercise-Induced Muscle Damage
Published: 9 September 2024
Abstract Views: 145
PDF: 59
HTML: 0
HTML: 0
Publisher's note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Authors
Exercise-Induced Muscle Damage (EIMD) is the disruption of skeletal muscle after high-intensity exercise, leading to decreased performance. Furthermore, it is a common condition following vigorous exercise, particularly in individuals unaccustomed to performance. This disruption results in a decrease in strength, muscle soreness, swelling, and the release of several cytokines, both inflammatory and anti-inflammatory. Symptoms of EIMD include Delayed-Onset Muscle Soreness (DOMS) and a loss of physical function. Therefore, this study aimed to investigate the effect of a 14-day administration of yacon leaves capsule supplementation on DOMS and inflammation post-EIMD. To achieve this, an experimental pretest and posttest control group design with a randomized control trial approach was adopted. A total of 32 Recreational male students of the Sports Science Universitas Negeri Surabaya were randomly and double-blindly assigned to either yacon capsule supplementation (n=16) or placebo (n=16) group. Participants were instructed to take a yacon capsule or placebo after breakfast for 14 days. The study groups were subjected to a muscle-damaging protocol consisting of 7 sets of 10 eccentric single-leg press repetitions on a leg press machine. DOMS and Interleukin 6 (IL-6) were determined at 0-h (baseline), 24-h, and 48-h post-exercise before and after 14-day supplementation periods. The results showed that DOMS and IL-6 serum increased at 24 hours post-EIMD when compared to baseline. Additionally, a significant reduction in both DOMS and IL-6 serum levels was observed within the yacon group compared to the placebo group (p<0.05). In conclusion, yacon leaves capsule supplementation was able to attenuate the risk of muscle damage by decreasing DOMS levels and IL-6 serum in the blood.
Sulistyarto S, Irawan R, Kumaat NA, Rimawati N. Correlation of Delayed Onset Muscle Soreness and Inflammation Post-exercise Induced Muscle Damage. Open Access Macedonian J Med Sc 2022 Jan 1;10(A):1688–94.
Sonkodi B. Delayed Onset Muscle Soreness and Critical Neural Microdamage-Derived Neuroinflammation. Biomolecules 2022;12:1207.
Nanavati K, Rutherfurd-Markwick K, Lee SJ, Bishop NC, Ali A. Effect of curcumin supplementation on exercise-induced muscle damage: a narrative review. Eur J Nutr 2022;61:3835-3855.
Irawan R, Mahmudiono T, Martiana T. Interleukin-6 as Immune System and Inflammation Biomarker on the Response of Basic Pencak Silat Exercise in Perguruan Pencak Silat Perisai Diri, Bojonegoro. Open Access Macedonian J Med Sci 2021;9:179–83.
Zulaini, Harahap NS, Siregar NS, Zulfahri. Effect Stretching and Recovery on Delayed Onset Muscle Soreness (DOMS) After Exercise. J Phys: Conf Ser 2021;1811:012113.
Kristensen NS, Hertel E, Skadhauge CH, et al. Psychophysical predictors of experimental muscle pain intensity following fatiguing calf exercise. PLoS One 2021;16:e0253945.
Heiss R, Lutter C, Freiwald J, et al. Advances in Delayed-Onset Muscle Soreness (DOMS) - Part II: Treatment and Prevention. Sportverletz Sportschaden 2019;33:21-9.
Hotfiel T, Freiwald J, Hoppe MW, et al. Advances in Delayed-Onset Muscle Soreness (DOMS): Part I: Pathogenesis and Diagnostics. Sportverletz Sportschaden 2018;32:243-250.
Udani JK, Singh BB, Singh VJ, Sandoval E. BounceBack capsules for reduction of DOMS after eccentric exercise: a randomized, double-blind, placebo-controlled, crossover pilot study. J Int Soc Sports Nutr 2009;6:14.
Angelopoulos P, Diakoronas A, Panagiotopoulos D, et al. Cold-Water Immersion and Sports Massage Can Improve Pain Sensation but Not Functionality in Athletes with Delayed Onset Muscle Soreness. Healthcare (Basel) 2022;10:2449.
Wilke J, Behringer M. Is "Delayed Onset Muscle Soreness" a False Friend? The Potential Implication of the Fascial Connective Tissue in Post-Exercise Discomfort. Int J Mol Sci 2021;22:9482.
Tanabe Y, Chino K, Ohnishi T, et al. Effects of oral curcumin ingested before or after eccentric exercise on markers of muscle damage and inflammation. Scand J Med Sci Sports 2019;29:524-34.
Boukhris O, Trabelsi K, Abdessalem R, et al. Effects of the 5-m Shuttle Run Test on Markers of Muscle Damage, Inflammation, and Fatigue in Healthy Male Athletes. Int J Environ Res Public Health 2020;17:4375.
Nakhostin-Roohi B, Nasirvand Moradlou A, Mahmoodi Hamidabad S, Ghanivand B. The Effect of Curcumin Supplementation on Selected Markers of Delayed Onset Muscle Soreness (DOMS). Ann Appl Sport Sci 2016;4:25–31.
Irawan RJ, Sulistyarto S, Rimawati N. Supplementation of Kencur (Kaempferia Galanga Linn) Extract on Malondealdehyde (MDA) and Interleukin-6 (IL-6) Plasma Levels Post Aerobic Training Activity: Suplementasi Ekstrak Kencur (Kaempferia Galanga linn) terhadap Kadar Plasma Malondealdehide (MDA) dan Interleukin-6 (IL-6) Pasca Aktivitas Latihan Aerobik. AMNT 2022;6:140-5.
Rickards L, Lynn A, Harrop D, et al. Effect of Polyphenol-Rich Foods, Juices, and Concentrates on Recovery from Exercise Induced Muscle Damage: A Systematic Review and Meta-Analysis. Nutrients 2021;13:2988.
Chen HY, Chen YC, Tung K, et al. Effects of caffeine and sex on muscle performance and delayed-onset muscle soreness after exercise-induced muscle damage: a double-blind randomized trial. J Appl Physiol (1985) 2019;127:798-805.
Vaile J, Halson S, Gill N, Dawson B. Effect of hydrotherapy on the signs and symptoms of delayed onset muscle soreness. Eur J Appl Physiol 2008;102:447-55. Erratum in: Eur J Appl Physiol 2008;103:121-2.
Nicol LM, Rowlands DS, Fazakerly R, Kellett J. Curcumin supplementation likely attenuates delayed onset muscle soreness (DOMS). Eur J Appl Physiol 2015;115:1769-77.
Gokhale R, Chandrashekara S, Vasanthakumar KC. Cytokine response to strenuous exercise in athletes and non-athletes--an adaptive response. Cytokine 2007;40:123-7.
Lamb KL, Ranchordas MK, Johnson E, et al. No Effect of Tart Cherry Juice or Pomegranate Juice on Recovery from Exercise-Induced Muscle Damage in Non-Resistance Trained Men. Nutrients 2019;11:1593.
Chang WD, Lin HY, Chang NJ, Wu JH. Effects of 830 nm Light-Emitting Diode Therapy on Delayed-Onset Muscle Soreness. Evidence-Based Complement Alternat Med 2021;2021:6690572.
Doma K, Burt D, Connor JD. The acute effect of a multi-modal plyometric training session on field-specific performance measures. J Sports Med Phys Fitness 2021;61:899-906.
Martínez-Ferrán M, Cuadrado-Peñafiel V, Sánchez-Andreo JM, et al. Effects of Acute Vitamin C plus Vitamin E Supplementation on Exercise-Induced Muscle Damage in Runners: A Double-Blind Randomized Controlled Trial. Nutrients 2022;14:4635.
Fleckenstein J, Neuberger EWI, Bormuth P, et al. Investigation of the Sympathetic Regulation in Delayed Onset Muscle Soreness: Results of an RCT. Front Physiol 2021;12:697335.
Pyne DB. Exercise-induced muscle damage and inflammation: a review. Aust J Sci Med Sport 1994;26:49-58.
Torre MF, Martinez-Ferran M, Vallecillo N, et al. Supplementation with Vitamins C and E and Exercise-Induced Delayed-Onset Muscle Soreness: A Systematic Review. Antioxidants (Basel) 2021;10:279.
Connolly DA, Sayers SP, McHugh MP. Treatment and prevention of delayed onset muscle soreness. J Strength Cond Res 2003;17:197-208.
Sonkodi B, Hegedűs Á, Kopper B, Berkes I. Significantly Delayed Medium-Latency Response of the Stretch Reflex in Delayed-Onset Muscle Soreness of the Quadriceps Femoris Muscles Is Indicative of Sensory Neuronal Microdamage. J Funct Morphol Kinesiol 2022;7:43.
Barker GA, Parten AL, Lara DA, et al. Astaxanthin Supplementation Reduces Subjective Markers of Muscle Soreness following Eccentric Exercise in Resistance-Trained Men. Muscles 2023;2:228–37.
Tanabe Y, Fujii N, Suzuki K. Dietary Supplementation for Attenuating Exercise-Induced Muscle Damage and Delayed-Onset Muscle Soreness in Humans. Nutrients 2021;14:70.
Jamurtas AZ. Exercise-Induced Muscle Damage and Oxidative Stress. Antioxidants (Basel) 2018;7:50.
Lin CH, Lin YA, Chen SL, et al. American Ginseng Attenuates Eccentric Exercise-Induced Muscle Damage via the Modulation of Lipid Peroxidation and Inflammatory Adaptation in Males. Nutrients 2021;14:78.
Andrade E, Ellendersen L, Masson M. Phenolic profile and antioxidant activity of extracts of leaves andflowers of yacon (Smallanthus sonchifolius). Industrial Crops Products 2014;62:499–506.
Widowati W, Tjokropranoto R, Onggowidjaja P, et al. Protective effect of yacon leaves extract (Smallanthus sonchifolius (Poepp.) H. Rob) through antifibrosis, anti-inflammatory, and antioxidant mechanisms toward diabetic nephropathy. Res Pharm Sci 2023;18:336-45.
Kim K, Lim Y, Oh JH, et al. Antioxidant Effect of Mulberry Leaves and Yacon Tuber Extracts in High-fat Diet-fed Rats. Biomed Sci Letters 2020;26:201–9.
Hachkova H, Nagalievska M, Soliljak Z, et al. Medicinal Plants Galega officinalis L. and Yacon Leaves as Potential Sources of Antidiabetic Drugs. Antioxidants (Basel) 2021;10:1362.
Powers SK, Deminice R, Ozdemir M, et al. Exercise-induced oxidative stress: Friend or foe? J Sport Health Sci 2020;9:415-25.
Jakubczyk K, Dec K, Kałduńska J, et al. Reactive oxygen species - sources, functions, oxidative damage. Pol Merkur Lekarski 2020;48:124-7.
Gomez-Cabrera MC, Domenech E, Viña J. Moderate exercise is an antioxidant: upregulation of antioxidant genes by training. Free Radic Biol Med 2008;44:126-31.
Di Meo S, Napolitano G, Venditti P. Mediators of Physical Activity Protection against ROS-Linked Skeletal Muscle Damage. Int J Mol Sci 2019;20:3024.
Northeast B, Clifford T. The Effect of Creatine Supplementation on Markers of Exercise-Induced Muscle Damage: A Systematic Review and Meta-Analysis of Human Intervention Trials. Int J Sport Nutr Exerc Metab 2021;31:276-291.
Sara HS. Effects of Electrotherapy on Delayed Onset Muscle Soreness (DOMS). J Biomed Res Environ Sci 2021;2:812–4.
Lee MC, Jhang WL, Lee CC, et al. The Effect of Kefir Supplementation on Improving Human Endurance Exercise Performance and Antifatigue. Metabolites 2021;11:136.
Cheung K, Hume P, Maxwell L. Delayed onset muscle soreness : treatment strategies and performance factors. Sports Med 2003;33:145-64.
Mizumura K, Taguchi T. Delayed onset muscle soreness: Involvement of neurotrophic factors. J Physiol Sci 2016;66:43-52.
Ferraz APCR, Garcia JL, Costa MR, et al. Yacon (Smallanthus sonchifolius) use as an antioxidant in diabetes. In: Pathology Elsevier; 2020 [cited 2023 Apr 10]. p. 379–86. Available from: https://linkinghub.elsevier.com/retrieve/pii/B9780128159729000366.
Djalalinia S, Hasani M, Asayesh H, et al. The effects of dietary selenium supplementation on inflammatory markers among patients with metabolic diseases: a systematic review and meta-analysis of randomized controlled trials. J Diabetes Metab Disord 2021;20:1051-62.
How to Cite
Irawan, R. J., Sudijandoko, A., Wahyudi, H., Kumaat, N. A., Bawono, M. N., Rimawati, N., & Wijayanto, A. (2024). Preventive effect of yacon leaves capsule in reducing symptoms of Exercise-Induced Muscle Damage. Healthcare in Low-Resource Settings, 12(s1). https://doi.org/10.4081/hls.2024.13031
Copyright (c) 2024 the Author(s)
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.