Practical experience of allergy to egg proteins clinical manifestation

Submitted: 26 February 2024
Accepted: 17 June 2024
Published: 9 August 2024
Abstract Views: 30
PDF: 13
Publisher's note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.

Authors

Food allergy occupies a significant place among disorders that impair the quality of patients’ lives, bringing a large number of restrictions to their diet and lifestyle. Therefore, the purpose of this study is to examine the clinical features of allergy to chicken eggs with the determination of key trends in diagnosis and treatment. A descriptive and comparative analysis of three cases was carried out with a large-scale assessment of specific Immunoglobulins E (IgE), determined by the enzyme-linked immunosorbent assay. It becomes clear, that due to the high prevalence of allergy to white and yolk of chicken eggs in the general population (among the Polish population including), chicken eggs have severe allergenic characteristics and may display various symptoms that may be problematic to differentiate. The patients from the presented cases were characterized by a severe course of the disease – minimal consumption of chicken eggs led to the development of urticaria, swelling of the eyelids, and bronchospasm, which required urgent administration of adrenaline and hospitalization. For the purpose of diagnosis, patients with anaphylactic reactions are highly restricted, because methods of skin prick testing, and provocation tests (oral and nasal) are contraindicated. In this regard, molecular diagnostics and the determination of specific immunoglobulins E for ovalbumin, ovomucoid, and other glycoproteins are recommended. This research can lead to the creation of purified recombinant allergens for use in the process of diagnosis and treatment, as well as in the food industry, also, it emphasizes the introduction of preventive measures for the development of anaphylaxis.

Dimensions

Altmetric

PlumX Metrics

Downloads

Download data is not yet available.

Citations

Johansson E, Mersha T. Genetics of food allergy. Immunol Allergy Clin North Am 2021;41:301-19. DOI: https://doi.org/10.1016/j.iac.2021.01.010
Zambrowicz A, Dąbrowska A, Bobak Ł, Szołtysik M. Egg yolk proteins and peptides with biological activity. Postepy Hig Med Dosw 2014;68:1524-9. DOI: https://doi.org/10.5604/17322693.1133600
Chen YP, Li D, Zhang XC, et al. Azacytidine-induced hypomethylation delays senescence and coloration in harvested strawberries by stimulating antioxidant enzymes and modulating abscisate metabolism to minimize anthocyanin overproduction. Food Chem 2023;407:135189. DOI: https://doi.org/10.1016/j.foodchem.2022.135189
Godovanets OI, Kotelban AV, Hrynkevych L, et al. Potential effectiveness of poly-vitamins and probiotics among preschool children living within iodine deficiency territory to caries prevention. Pesq Bras Odontopediatria Clín Integr 2020;21:1-11. DOI: https://doi.org/10.1590/pboci.2021.028
Savage J, Johns C. Food allergy: epidemiology and natural history. Immunol Allergy Clin North Am 2015;35:45-59. DOI: https://doi.org/10.1016/j.iac.2014.09.004
Lyons SA, Clausen M, Knulst AC, et al. Prevalence of food sensitization and food allergy in children across Europe. J Allergy Clin Immunol Pract 2020;8:2736-46.e9. DOI: https://doi.org/10.1016/j.jaip.2020.04.020
Lunhui H, Yanhong S, Shaoshen L, et al. Component resolved diagnosis of egg yolk is an indispensable part of egg allergy. Allergol Immunopathol 2021;49:6-14. DOI: https://doi.org/10.15586/aei.v49i2.31
Sicherer S, Abrams E, Nowak-Wegrzyn A, Hourihane J. Managing food allergy when the patient is not highly allergic. J Allergy Clin Immunol Practice 2022;10:46-55. DOI: https://doi.org/10.1016/j.jaip.2021.05.021
Chokshi N, Sicherer S. Molecular diagnosis of egg allergy: an update. Exp Rev Molec Diagn 2015;15:895-906. DOI: https://doi.org/10.1586/14737159.2015.1041927
Leech S, Ewan P, Skypala I, et al. BSACI 2021 guideline for the management of egg allergy. Clin Experim Allergy 2021;51:1262-78. DOI: https://doi.org/10.1111/cea.14009
Bongiovanni A, Parisi GF, Scuderi MG, et al. Gastroesophageal reflux and respiratory diseases: Does a real link exist? Minerva Pediatr 2019;71:515-23. DOI: https://doi.org/10.23736/S0026-4946.19.05531-2
Samady W, Warren C, Wang J, et al. Egg allergy in US children. J Allergy Clin Immunol Practice 2020;8:3066-73.e6. DOI: https://doi.org/10.1016/j.jaip.2020.04.058
Grimshaw KEC, Roberts G, Selby A, et al. Risk factors for hen’s egg allergy in Europe: EuroPrevall birth cohort. J Allergy Clin Immunol Pract 2020;8:1341-8.e5. DOI: https://doi.org/10.1016/j.jaip.2019.11.040
Ünsal H, Dal S, Akarsu A, et al. Phenotypes of persistent hen’s egg allergy in children and adolescents. Turk J Pediatr 2023;65:3-12. DOI: https://doi.org/10.24953/turkjped.2021.5417
Jeebhay M, Baatjies R. Occupational inhalant allergy in food handling occupations. Curr Opin Allergy Clin Immunol 2022;22:64-72. DOI: https://doi.org/10.1097/ACI.0000000000000804
di Palmo E, Gallucci M, Cipriani F, et al. Asthma and food allergy: which risks? Med 2019;55:509. DOI: https://doi.org/10.3390/medicina55090509
Sicherer S, Warren C, Dant C, et al. Food allergy from infancy through adulthood. J Allergy Clin Immunol Practice 2020;8:1854-64. DOI: https://doi.org/10.1016/j.jaip.2020.02.010
Campmans-Kuijpers M, Dijkstra G. Food and food groups in Inflammatory Bowel Disease (IBD): the design of the Groningen Anti-Inflammatory Diet (GrAID). Nutr 2021;13:1067. DOI: https://doi.org/10.3390/nu13041067
Kostecka M, Kostecka-Jarecka J, Kostecka J, et al. Parental knowledge about allergies and problems with an elimination diet in children aged 3 to 6 years. Child 2022;9:1693. DOI: https://doi.org/10.3390/children9111693
Foong R, Dantzer J, Wood R, Santos A. Improving diagnostic accuracy in food allergy. J Allergy Clin Immunol Practice 2021;9:71-80. DOI: https://doi.org/10.1016/j.jaip.2020.09.037
Almeida A, Perger E, Gomes R, et al. Objective evaluation of immediate reading skin prick test applying image planimetric and reaction thermometry analyses. J Immunol Method 2020;487:112870. DOI: https://doi.org/10.1016/j.jim.2020.112870
Pitsios C, Dimitriou A, Stefanaki E, Kontou-Fili K. Anaphylaxis during skin testing with food allergens in children. Euro J Pediatr 2010;169:613-5. DOI: https://doi.org/10.1007/s00431-009-1070-5
Hernández-Moreno K, Diez L. Systemic reaction after performing a food prick-to-prick test. A case report. Rev Alergia Mexico 2017;64:126-9. DOI: https://doi.org/10.29262/ram.v64i1.200
Kido J, Nishi N, Matsumoto T. The oral provocation test for raw egg in patients with hen egg allergy. Int Arch Allergy Immunol 2018;177:40-4. DOI: https://doi.org/10.1159/000489098
Maltsev DV. Efficiency of a high-dose intravenous immunoglobulin therapy in children with Autism Spectrum Disorders associated with genetic deficiency of folate cycle enzymes. J Global Pharma Technol 2019;11:597-609.
Dona D, Suphioglu C. Egg allergy: diagnosis and immunotherapy. Int J Molec Sci 2020;21:5010. DOI: https://doi.org/10.3390/ijms21145010
Steering Committee Authors, Review Panel Members. A WAO – ARIA – GA2LEN consensus document on molecular-based allergy diagnosis (PAMD@): Update 2020. World Allergy Org J 2020;13:100091. DOI: https://doi.org/10.1016/j.waojou.2019.100091
Balińska-Miśkiewicz W. Molecular diagnosis of food allergy – Do we know more? Postepy Hig Med Dosw 2014;68;754-67. DOI: https://doi.org/10.5604/17322693.1108336
de Silva D, Halken S, Singh C, et al. Preventing food allergy in infancy and childhood: Systematic review of randomised controlled trials. Pediat Allergy Immunol 2020;31:813-26. DOI: https://doi.org/10.1111/pai.13273
Sokołowicz Z, Kačániová M, Dykiel M, et al. Influence of storage packaging type on the microbiological and sensory quality of free-range table eggs. Animals 2023;13:1899. DOI: https://doi.org/10.3390/ani13121899
Mine Y, Wei Zhang J. Identification and fine mapping of IgG and IgE epitopes in ovomucoid. Biochem Biophys Res Commun 2002;292:1070-4. DOI: https://doi.org/10.1006/bbrc.2002.6725
Dhanapala P, Withanage-Dona D, Tang M, et al. Hypoallergenic variant of the major egg white allergen Gal d 1 produced by disruption of cysteine bridges. Nutr 2017;9:171. DOI: https://doi.org/10.3390/nu9020171
Moghtaderi M, Nabavizadeh S, Hosseini Teshnizi S. The frequency of cross-reactivity with various avian eggs among children with hen’s egg allergy using skin prick test results: fewer sensitizations with pigeon and goose egg. Allergol Immunopathol 2020;48:265-9. DOI: https://doi.org/10.1016/j.aller.2019.10.002
Lee J, Gantulga P, Lee C, et al. A preliminary study on cross-reactivity of heat-treated quail and hen’s egg white proteins in young children. Nutr 2021;13:2172. DOI: https://doi.org/10.3390/nu13072172
Langeland T. A clinical and immunological study of allergy to hen’s egg white. VI. Occurrence of proteins cross-reacting with allergens in hen’s egg white as studied in egg white from turkey, duck, goose, seagull, and in hen egg yolk, and hen and chicken sera and flesh. Allergy 1983;38:399-412. DOI: https://doi.org/10.1111/j.1398-9995.1983.tb05083.x
LoVerde D, Iweala O, Eginli A, Krishnaswamy G. Anaphylaxis. Chest 2018;153:528-43. DOI: https://doi.org/10.1016/j.chest.2017.07.033
Hemmer W, Klug C, Swoboda I. Update on the bird-egg syndrome and genuine poultry meat allergy. Allergo J Int 2016;25:68-75. DOI: https://doi.org/10.1007/s40629-016-0108-2
Gargano D, Appanna R, Santonicola A, et al. Food allergy and intolerance: a narrative review on nutritional concerns. Nutr 2021;13:1638. DOI: https://doi.org/10.3390/nu13051638
Caffarelli C, Giannetti A, Rossi A, Ricci G. Egg allergy in children and weaning diet. Nutr 2022;14:1540. DOI: https://doi.org/10.3390/nu14081540
Parisi GF, Leonardi S, Ciprandi G, et al. Cetirizine use in childhood: An update of a friendly 30-year drug. Clin Mol Allergy 2020;18:2. DOI: https://doi.org/10.1186/s12948-020-00118-5
Parisi GF, Leonardi S, Ciprandi G, et al. Antihistamines in children and adolescents: a practical update. Allergol Immunopathol (Madr). 2020;48:753-62. DOI: https://doi.org/10.1016/j.aller.2020.02.005
Nucera E, Inchingolo R, Nicotra R, et al. Influence of antihistamines on basophil activation test in food allergy to milk and egg. Diagnost 2020;11:44. DOI: https://doi.org/10.3390/diagnostics11010044
Patriarca G, Schiavino D, Pecora V, et al. Food allergy and food intolerance: diagnosis and treatment. Intern Emerg Med 2009;4:11-24. DOI: https://doi.org/10.1007/s11739-008-0183-6
Muraro A, Worm M, Alviani C, et al. EAACI guidelines: Anaphylaxis (2021 update). Allergy 2022;77:357-77. DOI: https://doi.org/10.1111/all.15032
Kraft M, Dölle-Bierke S, Turner P, et al. EAACI Task Force Clinical epidemiology of anaphylaxis: experts’ perspective on the use of adrenaline autoinjectors in Europe. Clin Trans Allergy 2020;10:12 DOI: https://doi.org/10.1186/s13601-020-00317-y
Schapovalova O, Gorlova A, de Munter J, et al. Immunomodulatory effects of new phytotherapy on human macrophages and TLR4- and TLR7/8-mediated viral-like inflammation in mice. Front Med 2022;9:952977. DOI: https://doi.org/10.3389/fmed.2022.952977
Turmagambetova AS, Sokolova NS, Bogoyavlenskiy AP, et al. New functionally-enhanced soy proteins as food ingredients with anti-viral activity. Virus Dis 2015;26:123-32. DOI: https://doi.org/10.1007/s13337-015-0268-6
Mandziy ZP, Boichuk OH, Myhovych VV. Correction of iron deficiency in the clinical picture of internal medicine. Emerg Med (Ukraine) 2021;17:64-70. DOI: https://doi.org/10.22141/2224-0586.17.3.2021.234811
Muraro A, de Silva D, Halken S, et al. Managing food allergy: GA2LEN guideline 2022. World Allergy Org J 2022;15:100687. DOI: https://doi.org/10.1016/j.waojou.2022.100723
Sahiner U, Giovannini M, Escribese M, et al. Mechanisms of allergen immunotherapy and potential biomarkers for clinical evaluation. J Personal Med 2023;13:845. DOI: https://doi.org/10.3390/jpm13050845
Marcucci F, Isidori C, Argentiero A, et al. Therapeutic perspectives in food allergy. J Trans Med 2020;18:302. DOI: https://doi.org/10.1186/s12967-020-02466-x
Lam H, Tergaonkar V, Ahn K. Mechanisms of allergen-specific immunotherapy for allergic rhinitis and food allergies. Biosci Rep 2020;40:BSR20200256. DOI: https://doi.org/10.1042/BSR20200256
Durham S, Shamji M. Allergen immunotherapy: past, present and future. Nat Rev Immunol 2023;23:317-28. DOI: https://doi.org/10.1038/s41577-022-00786-1
Pavón-Romero G, Parra-Vargas M, Ramírez-Jiménez F, et al. Allergen immunotherapy: current and future trends. Cells 2022;11:212. DOI: https://doi.org/10.3390/cells11020212

How to Cite

Lisiecka, M. Z. (2024). Practical experience of allergy to egg proteins clinical manifestation. Healthcare in Low-Resource Settings. https://doi.org/10.4081/hls.2024.12430