https://doi.org/10.4081/hls.2024.11985
Analysis of determinants of infertility among women at in vitro fertilization clinic in Surabaya
Submitted: 15 October 2023
Accepted: 30 May 2024
Published: 1 July 2024
Accepted: 30 May 2024
Abstract Views: 380
PDF: 100
HTML: 1
HTML: 1
Publisher's note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Authors
In social life and global health, infertility is common. History of abdominal surgery, body mass index (BMI), endometriosis, menstrual history, and polycystic ovarian syndrome (PCOS) have not been fully explained as female infertility factors. This study examined infertility causes at ASHA in vitro fertilization Primasatya Husada Citra (PHC) Hospital Surabaya. This quantitative study was cross-sectional. In May-July 2023, 82 childbearing-age women with infertility issues visited the hospital and completed questionnaires. Description and analysis were performed using the Wilcoxon rank test to evaluate menstrual history, BMI, PCOS, endometriosis, and abdominal surgery history in relation to infertility. Infertility was statistically associated with abdominal surgery history (P=0.008), BMI (P=0.000), endometriosis diagnosis (P=0.000), and PCOS (P=0.000). Women with abdominal surgery, endometriosis, and PCOS had significant infertility. Women’s infertility can be caused by ovulation disorders, tubal and pelvic disorders, or uterine disorders, but one-third of cases are unexplained. Infertility treatment may benefit from addressing abdominal surgery history, BMI, endometriosis, and PCOS. Early intervention and targeted care based on these determinants may improve fertility outcomes and reduce unexplained infertility.
Bahar F, Zalika P, Lestari SW, et al. Male infertility as a bad news: A review. J Glob Pharma Technol 2019;11:109-14.
Alhassan A, Ziblim AR, Muntaka S. A survey on depression among infertile women in Ghana. BMC Womens Health 2014;14:42.
DOI: https://doi.org/10.1186/1472-6874-14-42
Novrika B. Hubungan mekanisme koping dengan tingkat kecemasan pada pasangan infertil di RSIA Annisa Jambi tahun 2015. Ris Inf Kesehat 2018;6:184.
DOI: https://doi.org/10.30644/rik.v6i2.97
Kemenkes RI, Kementrian Kesehatan Republik Indonesia. Hasil Riset Kesehatan Dasar Tahun 2018;1689-99.
Ngai F-W, Loke AY. Relationships between infertility-related stress, family sense of coherence and quality of life of couples with infertility. Hum Fertil 2022;25:540-7.
DOI: https://doi.org/10.1080/14647273.2021.1871781
Bhattacharjee NV, Schumacher AE, Aali A, et al. Global fertility in 204 countries and territories, 1950–2021, with forecasts to 2100: a comprehensive demographic analysis for the Global Burden of Disease Study 2021. Lancet 2024;403:2057-99.
DOI: https://doi.org/10.1016/S0140-6736(24)00550-6
Ferreira M, Antunes L, Duarte J, Chaves C. Influence of infertility and fertility adjustment on marital satisfaction. Procedia Soc Behav Sci 2015;171:96-103.
DOI: https://doi.org/10.1016/j.sbspro.2015.01.094
Fritz MA, Speroff L. Female infertility. In: Clinical Gynecologic Endocrinology and Infertility. 8th ed. Wolters Kluwer Health; 2011.
Santoso B, Rahmawati NY, Sa’adi A, et al. Elevated peritoneal soluble endoglin and GDF-15 in infertile women with severe endometriosis and pelvic adhesion. J Reprod Immunol 2021;146.
DOI: https://doi.org/10.1016/j.jri.2021.103343
Dağ ZÖ, Dilbaz B. Impact of obesity on infertility in women. J Turkish Ger Gynecol Assoc 2015;16:111-7.
DOI: https://doi.org/10.5152/jtgga.2015.15232
de Angelis C, Nardone A, Garifalos F, et al. Smoke, alcohol and drug addiction and female fertility. Reprod Biol Endocrinol 2020;18:21.
DOI: https://doi.org/10.1186/s12958-020-0567-7
Sirait BI, Reviani N, Udjung GIVW. Factors affecting infertility in women of reproductive age in the IVF programme. Int J Trop Dis Heal 2023;44:65-75.
DOI: https://doi.org/10.9734/ijtdh/2023/v44i11386
Zhu L, Zhou B, Zhu X, et al. Association between body mass index and female infertility in the united states: data from national health and nutrition examination survey 2013-2018. Int J Gen Med 2022;15:1821-31.
DOI: https://doi.org/10.2147/IJGM.S349874
Finelli R, Mottola F, Agarwal A. Impact of alcohol consumption on male fertility potential: a narrative review. Int J Environ Res Public Health 2021;19.
DOI: https://doi.org/10.3390/ijerph19010328
Kovac JR, Khanna A, Lipshultz LI. The effects of cigarette smoking on male fertility. Postgrad Med 2015;127:338-41.
DOI: https://doi.org/10.1080/00325481.2015.1015928
Hashemi AH, Mozdarani H, Mozdarani S. The relationship between hormones level and body mass index with insertion and deletion (D/I) polymorphism of ACE gene in infertile patients with polycystic ovary syndrome. Bali Med J 2017;6:90-6.
DOI: https://doi.org/10.15562/bmj.v6i1.382
Benksim A, Elkhoudri N, Addi RA, et al. Difference between primary and secondary infertility in Morocco: frequencies and associated factors. Int J Fertil Steril 2018;12:142-6.
Igarashi H, Takahashi T, Nagase S. Oocyte aging underlies female reproductive aging: biological mechanisms and therapeutic strategies. Reprod Med Biol 2015;14:159-69.
DOI: https://doi.org/10.1007/s12522-015-0209-5
Dewi NLPMC, Lindayani IK, Rahyani NKY, Suindri NN. Gambaran Faktor-Faktor Penyebab Infertilitas Dan Tingkat Keberhasilan Program Bayi Tabung Yang Diikuti Oleh Pasangan Usia Subur. J Ilm Kebidanan (J Midwifery) 2022;10:1-8.
DOI: https://doi.org/10.33992/jik.v10i1.1557
Piyakong D, Apiratanawong S, Suasing C. Insights from leaders on effectively addressing overweight and obesity in the Thai community. J Ners 2023;18:117-23.
DOI: https://doi.org/10.20473/jn.v18i2.44167
Handini A, Mirfat M. Hubungan Usia dan Obesitas dengan Infertilitas pada pasien di Rumah Sakit Kepresidenan RSPAD Gatot Soebroto. Maj Kesehat Pharmamedika 2018;9:33.
DOI: https://doi.org/10.33476/mkp.v9i1.673
Vembu R, Devi MN, Nellepalli SR, et al. Impact of body mass index on the prevalence of metabolic syndrome among infertile south Indian women. Int J Infertil Fetal Med 2020;10:42-5.
DOI: https://doi.org/10.5005/jp-journals-10016-1188
Wiyono T, Dwiningsih SR, Widjiati W. The impact of endometriosis on intracellular calcium levels, cyclic dependent kinase 1 (Cdk1) expression, and cyclin b expression in post-ovulation oocytes of mice model. J Reprod Infertil 2023;24:232-9.
DOI: https://doi.org/10.18502/jri.v24i4.14150
Kim M-R, Chapron C, Römer T, et al. Clinical Diagnosis and Early Medical Management for Endometriosis: Consensus from Asian Expert Group. Healthcare 2022;10.
DOI: https://doi.org/10.3390/healthcare10122515
Hendarto H. Endometriosis Dari Aspek teori sampai penanganan klinis. Airlangga University Press; 2015.
Rahmawati NY, Ahsan F, Santoso B, et al. Role of TNF superfamily members lymphotoxin-α, sCD40L, and TNF-α in endometriosis-related infertility. J Endometr Pelvic Pain Disord 2024;0.
DOI: https://doi.org/10.1177/22840265241231722
Macer ML, Taylor HS. Endometriosis and infertility: a review of the pathogenesis and treatment of endometriosis-associated infertility. Obstet Gynecol Clin North Am 2012;39:535-49.
DOI: https://doi.org/10.1016/j.ogc.2012.10.002
Mareta R, Amran R, Larasati V. Hubungan polycystic ovary syndrome (PCOS) dengan infertilitas di praktik swasta dokter obstetri ginekologi Palembang. Maj Kedokt Sriwij 2018;50:85-91.
Rachmawati DA, Sa’adi A, Utomo B, Tunjungseto A. Relationship between angiopoietin-like-protein-2 levels and anti-mullerian hormone levels in polycystic ovary syndrome of reproductive age. Bali Med J 2023;12:861-5.
DOI: https://doi.org/10.15562/bmj.v12i1.4201
Santoso B, Rusnaidi, Widjiati. Effect of alpha lipoic acid on polycystic ovary syndrome with insulin resistance. Indian J Forensic Med Toxicol 2020;14:1015-20.
Calcaterra V, Verduci E, Cena H, et al. Polycystic ovary syndrome in insulin-resistant adolescents with obesity: the role of nutrition therapy and food supplements as a strategy to protect fertility. Nutrients 2021;13.
DOI: https://doi.org/10.3390/nu13061848
Supporting Agencies
Universitas Nahdlatul Ulama SurabayaHow to Cite
Safitri, Y. I., Rahayu , E. P., Rizki , L. K., Abidah, S. N., & Nadatien, I. (2024). Analysis of determinants of infertility among women at <i>in vitro</i> fertilization clinic in Surabaya. Healthcare in Low-Resource Settings, 12(3). https://doi.org/10.4081/hls.2024.11985
Copyright (c) 2024 the Author(s)
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.