https://doi.org/10.4081/hls.2024.11732
Correlation of nerve damage and peripheral neuropathy incidence using the MNSI and MDNS instrument approaches
Submitted: 9 September 2023
Accepted: 30 November 2023
Published: 18 January 2024
Accepted: 30 November 2023
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All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Authors
The World Health Organization (WHO) reported that by 2030, diabetes mellitus would become the 7th leading cause of death. Diabetes mellitus is a chronic disease that causes various complications, one of which is peripheral neuropathy. Preventive efforts for peripheral neuropathy involve conducting detection examinations. The purpose of this study was to analyze nerve damage in peripheral neuropathy cases using the MNSI (Michigan Neuropathy Screening Instrument) and MDNS (Michigan Diabetic Neuropathy Score) instruments. The study employed a cross-sectional study approach with a sample of 50 people, using total sampling as the sampling technique. The independent variable in this study was nerve damage, and the dependent variable was peripheral neuropathy. Data collection in the study was carried out using the MNSI and MDNS instruments to link the dependent and independent variables. Hypothesis analysis in this study was conducted using the Spearman's rho correlation test. The study found that autonomic, sensory, and motor damage correlated with peripheral neuropathy, with a P-value of < 0.05. Examinations in the feet of diabetics were significantly related to the level of peripheral neuropathy. However, there was no evidence of a correlation between the characteristics of the respondents and the incidence of peripheral neuropathy. The results of the nerve damage examination demonstrated a correlation between different types of damage, and the MNSI and MDNS instruments proved effective in detecting peripheral neuropathy damage. Future research should focus on more in-depth studies to explore the correlation of nerve damage in patients with diabetes mellitus detected at a young age and consider other variables, such as HbA1c levels, as potential risk factors for peripheral neuropathy.
Mboi N, Syailendrawati R, Ostroff SM, Elyazar IR, Glenn SD, Rachmawati T, et al. The state of health in Indonesia’s provinces, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019. Lancet Glob Health. 2022;10(11):e1632–45.
Adi Pamungkas R, Mayasari Usman A. Panduan Praktis Screening Resiko Diabetes dan Neuropathy . Listiyawati I, Rosyidi K, editors. Vol. Pertama. Bondowoso: KHD Production ; 2021.
Feldman EL, Callaghan BC, Pop-Busui R, Zochodne DW, Wright DE, Bennett DL, et al. Diabetic neuropathy. Nat Rev Dis Primers. 2019 Jun 13;5(1):41.
DOI: https://doi.org/10.1038/s41572-019-0092-1
Oliveira-Abreu K, Cipolla-Neto J, Leal-Cardoso JH. Effects of Melatonin on Diabetic Neuropathy and Retinopathy. Int J Mol Sci. 2021 Dec 22;23(1):100.
DOI: https://doi.org/10.3390/ijms23010100
Dixit S, Maiya A. Diabetic peripheral neuropathy and its evaluation in a clinical scenario: a review. J Postgrad Med. 2014;60(1):33–40.
DOI: https://doi.org/10.4103/0022-3859.128805
Hidayati L, Pratiwi IN, Pawanis Z, McKenna L, Widyawati IY. Buerger exercise reduces the risk of neuropathy in people with diabetes mellitus. Open Access Maced J Med Sci. 2021 Jan;9:94–9.
DOI: https://doi.org/10.3889/oamjms.2021.6743
Pop-Busui R, Boulton AJM, Feldman EL, Bril V, Freeman R, Malik RA, et al. Diabetic Neuropathy: A Position Statement by the American Diabetes Association. Diabetes Care. 2017 Jan 1;40(1):136–54.
DOI: https://doi.org/10.2337/dc16-2042
Hassanzadeh S, Bagheri S, Majid Ahmadi S, Ahmadi SA, Moradishibany I, Dolatkhah H, et al. Effectiveness of oral clonidine and gabapentin on peripheral neuropathy in diabetic patients in southwestern Iran: a randomized clinical trial. BMC Endocr Disord. 2023 Oct 16;23(1):224.
DOI: https://doi.org/10.1186/s12902-023-01486-0
IDF. Diabetes Atlas . 2017.
Hicks CW, Selvin E. Epidemiology of Peripheral Neuropathy and Lower Extremity Disease in Diabetes. Curr Diab Rep. 2019 Oct 27;19(10):86.
DOI: https://doi.org/10.1007/s11892-019-1212-8
Malik RA, Andag-Silva A, Dejthevaporn C, Hakim M, Koh JS, Pinzon R, et al. Diagnosing peripheral neuropathy in South-East Asia: A focus on diabetic neuropathy. J Diabetes Investig. 2020 Sep;11(5):1097–103.
DOI: https://doi.org/10.1111/jdi.13269
Dixit S, Maiya A, Shastry B. Effect of aerobic exercise on quality of life in population with diabetic peripheral neuropathy in type 2 diabetes: a single blind, randomized controlled trial. Quality of Life Research. 2014 Jun 11;23(5):1629–40.
DOI: https://doi.org/10.1007/s11136-013-0602-7
Akmal ASHHP. The Relationship Between Patient Characteristics Diabetes Self-Care Management with Diabetic Peripheral Neuropathy in Type 2 DM Patients in Regional General Hospital in Indonesia. International Journal of Nursing Education. 2022;14(4).
DOI: https://doi.org/10.37506/ijone.v14i4.18679
Oh TJ, Kang S, Lee JE, Moon JH, Choi SH, Lim S, et al. Association between deterioration in muscle strength and peripheral neuropathy in people with diabetes. J Diabetes Complications. 2019 Aug;33(8):598–601.
DOI: https://doi.org/10.1016/j.jdiacomp.2019.04.007
Atallah SM, Al-Jaghbir MT, Zayed AA. The prevalence of diabetic peripheral neuropathy among diabetic Palestinian refugees in the Nuzha area, Jordan: a cross-sectional study. The Lancet. 2021 Jul;398:S15.
DOI: https://doi.org/10.1016/S0140-6736(21)01501-4
Levitt Katz LE, White NH, El ghormli L, Chan CL, Copeland KC, Lipman TH, et al. Risk Factors for Diabetic Peripheral Neuropathy in Adolescents and Young Adults With Type 2 Diabetes: Results From the TODAY Study. Diabetes Care. 2022 May 1;45(5):1065–72.
DOI: https://doi.org/10.2337/dc21-1074
Mohapatra S, Ramachandran M, Behera KK, Priyadarsini N, Nanda P, Devi S. Association of peripheral neuropathy with skeletal muscle mass and function in type two diabetes mellitus patients: A cross-sectional study. Endocrinol Diabetes Nutr. 2022 Oct;69(8):591–9.
DOI: https://doi.org/10.1016/j.endinu.2022.03.010
Anumah FE, Lawal Y, Mshelia-Reng R, Omonua SO, Odumodu K, Shuaibu R, et al. Common and contrast determinants of peripheral artery disease and diabetic peripheral neuropathy in North Central Nigeria. The Foot. 2023 May;55:101987.
DOI: https://doi.org/10.1016/j.foot.2023.101987
Zhou L, Tang J, Cai Q, Wang Y, Wan Y, Lu X, et al. Survey of factors related to diabetic foot pruritus in the elderly in Shanghai. Int Wound J. 2023 Aug 26;20(6):2020–7.
DOI: https://doi.org/10.1111/iwj.14065
Elafros MA, Andersen H, Bennett DL, Savelieff MG, Viswanathan V, Callaghan BC, et al. Towards prevention of diabetic peripheral neuropathy: clinical presentation, pathogenesis, and new treatments. Lancet Neurol. 2022 Oct;21(10):922–36.
DOI: https://doi.org/10.1016/S1474-4422(22)00188-0
Sukartini T, Asmoro CP, Alifah PN. The Influence of Diabetic Foot Exercise in Sensory Peripheral Neuropathy with Monofilament Test on Diabetes Mellitus Clients. Jurnal Ners. 2019 Dec;14(3):340–4.
DOI: https://doi.org/10.20473/jn.v14i3.17263
Riyanto A. Aplikasi Metodologi Penelitian Kesehatan . Vol. III. Yogjakarta: Nuha Medika ; 2019.
W. H. Herman, R. Pop-Busui, B. H. Braffett, C. L. Martin, P. A. Cleary, J. W. Albers, et al. Use of the Michigan Neuropathy Screening Instrument as a measure of distal symmetrical peripheral neuropathy in Type 1 diabetes: results from the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications. Diabetic Medicine. 2022 Feb;39(4).
Sabaghan M, Ataee S, Ataee M, Tebyanian M, Afrashteh S, Daneshi N. Diabetic peripheral neuropathy screening and the related risk factors to its prevalence in people with type 2 diabetes. Int J Diabetes Dev Ctries. 2023 Oct 6;43(5):641–6.
Zou X, Zhou X, Ji L, Yang W, Lu J, Weng J, et al. The characteristics of newly diagnosed adult early-onset diabetes: a population-based cross-sectional study. Sci Rep. 2017 Apr 19;7(1):46534.
DOI: https://doi.org/10.1038/srep46534
Dong W, Zhang S, Yan S, Zhao Z, Zhang Z, Gu W. Clinical characteristics of patients with early-onset diabetes mellitus: a single-center retrospective study. BMC Endocr Disord. 2023 Oct 10;23(1):216.
DOI: https://doi.org/10.1186/s12902-023-01468-2
Ede O, Eyichukwu GO, Madu KA, Ogbonnaya IS, Okoro KA, Basil-Nwachuku C, et al. Evaluation of Peripheral Neuropathy in Diabetic Adults with and without Foot Ulcers in an African Population. J Biosci Med (Irvine). 2018;06(12):71–8.
DOI: https://doi.org/10.4236/jbm.2018.612007
Hamdan M, Wisnujono R, Basuki M, Fidiana, Fadil, Sudarmadi I. The association between blood glucose control measured with serum hna1c level with peroneal motor nerve conduction velocity in patients with type 2 diabetes mellitus with polyneuropathy. Indian Journal of Forensic Medicine and Toxicology. 2020 Jun 1;14(2):1649–54.
Pan J, Jia W. Early-onset diabetes: an epidemic in China. Front Med. 2018 Dec 5;12(6):624–33.
DOI: https://doi.org/10.1007/s11684-018-0669-1
Ardiany D, Pranoto A, Soelistijo SA, Libriansyah, Widjaja SA. Association between neutrophil–lymphocyte ratio on arterial stiffness in type-2 diabetes mellitus patients: a part of DiORS Study. Int J Diabetes Dev Ctries. 2022 Apr;42(2):305–12.
DOI: https://doi.org/10.1007/s13410-021-00965-1
Yokoyama H, Tsuji T, Hayashi S, Kabata D, Shintani A. Factors associated with diabetic polyneuropathy‐related sensory symptoms and signs in patients with polyneuropathy: A cross‐sectional Japanese study (JDDM 52) using a non‐linear model. J Diabetes Investig. 2020 Mar 6;11(2):450–7.
DOI: https://doi.org/10.1111/jdi.13117
Shrestha HK, Katwal PC. Prevalence and risk factors of diabetic peripheral neuropathy in T2DM patient presenting to commnity hospital in Nepal. Kathmandu Univ Med J. 2017;
Zhi WI, Dreyfus N, Lessing A, Galantino M, Piulson L, Kot KL, et al. Patient Characteristics Associated With Chemotherapy-Induced Peripheral Neuropathy Severity in a Phase II Clinical Trial: A Retrospective Analysis. Oncologist. 2023 Jul 5;28(7):604–8.
DOI: https://doi.org/10.1093/oncolo/oyad062
Debele GR, Kuse SA, Kefeni BT, Geda A, Jifar WW, Kitila KM, et al. Why too soon? Predictors of time to diabetic peripheral neuropathy among newly diagnosed diabetes mellitus patients: a multicenter follow-up study at health-care setting of Ethiopia. Archives of Public Health. 2023 Oct 21;81(1):186.
DOI: https://doi.org/10.1186/s13690-023-01202-3
Mauvais-Jarvis F, Manson JE, Stevenson JC, Fonseca VA. Menopausal Hormone Therapy and Type 2 Diabetes Prevention: Evidence, Mechanisms, and Clinical Implications. Endocr Rev. 2017 Jun 1;38(3):173–88.
DOI: https://doi.org/10.1210/er.2016-1146
Kautzky-Willer A, Harreiter J, Pacini G. Sex and Gender Differences in Risk, Pathophysiology and Complications of Type 2 Diabetes Mellitus. Endocr Rev. 2016 Jun 1;37(3):278–316.
DOI: https://doi.org/10.1210/er.2015-1137
Kusnanto K, Pradipta RO, Arifin H, Gusmaniarti G, Handiyani H, Klankhajhon S. What I felt as a diabetes fatigue survivor: a phenomenology study. J Diabetes Metab Disord [Internet]. 2022;21(2):1753–62. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85140108954&doi=10.1007%2Fs40200-022-01147-4&partnerID=40&md5=b7c9574e92ca8fa80078c87fd2fd05b7
Tanhardjo J, Pinzon RT, Sari LK. Perbandingan rerata kadar HbA1c pada pasien diabetes melitus dengan neuropati dan tanpa neuropati sensori motor. Berkala Ilmiah Kedokteran Duta Wacana. 2016;1(2).
DOI: https://doi.org/10.21460/bikdw.v1i2.13
Karmilayanti, Goysal Y, Basri MI, Aulina S, Bintang AK. The relationship between the severity of peripheral diabetic neuropathy and sleep quality in type 2 diabetic mellitus patients. Medicina Clínica Práctica. 2021 Apr;4:100210.
DOI: https://doi.org/10.1016/j.mcpsp.2021.100210
Faizah R, Efendi F, Suprajitno S. The effects of foot exercise with audiovisual and group support foot exercises to diabetes mellitus patients. J Diabetes Metab Disord. 2021 Jun;20(1):377–82.
DOI: https://doi.org/10.1007/s40200-021-00756-9
Szwarcbard N, Villani M, Earnest A, Flack J, Andrikopoulos S, Wischer N, et al. The association of smoking status with glycemic control, metabolic profile and diabetic complications– Results of the Australian National Diabetes Audit (ANDA). J Diabetes Complications. 2020 Sep;34(9):107626.
DOI: https://doi.org/10.1016/j.jdiacomp.2020.107626
Li M, Wu K, Chang J, Jiang W chen. A Retrospective Study on the Time in Range of Blood Glucose and Type 2 Diabetic Peripheral Neuropathy. Biomed Res Int. 2022 Jul 28;2022:1–6.
DOI: https://doi.org/10.1155/2022/2743679
Arifin H, Kusnanto K, Wahyuni ED, Pradipta RO. Diabetes Resilience Training on Self-Care, Glycemic Control, and Diabetes Burnout of Adult Type 2 Diabetes Mellitus. Indonesian Nursing Journal of Education and Clinic (Injec). 2019;4(2):90.
DOI: https://doi.org/10.24990/injec.v4i2.252
Concha LL, Durruty AP. Ketosis prone type 2 diabetes (KPD). Rev Med Chil. 2015;
Ren Y, Gao L, Guo X, Huo X, Lu J, Li J, et al. Interactive effect of serum uric acid and total bilirubin for micro-vascular disease of type 2 diabetes in China. J Diabetes Complications. 2018 Nov;32(11):1000–5.
DOI: https://doi.org/10.1016/j.jdiacomp.2018.09.002
Faizah R, Efendi F, Suprajitno S. The effects of foot exercise with audiovisual and group support foot exercises to diabetes mellitus patients. J Diabetes Metab Disord [Internet]. 2021; Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85101682595&doi=10.1007%2Fs40200-021-00756-9&partnerID=40&md5=bd53e8aba3899437d7eee805f5c45d97
Pratiwi LD, Haryanto J, Wahyudi AS. The Effect of Foot Self Care and Diabetes Self-management Mobile Application in Preventing Foot Ulcer Recurrence: A Systematic Review Study. Malaysian Journal of Medicine & Health Sciences. 2023;19.
Sabaghan M, Ataee S, Ataee M, Tebyanian M, Afrashteh S, Daneshi N. Diabetic peripheral neuropathy screening and the related risk factors to its prevalence in people with type 2 diabetes. Int J Diabetes Dev Ctries. 2023 Oct 6;43(5):641–6.
DOI: https://doi.org/10.1007/s13410-022-01165-1
Beijers AJM, Vreugdenhil G, Oerlemans S, Eurelings M, Minnema MC, Eeltink CM, et al. Chemotherapy-induced neuropathy in multiple myeloma: influence on quality of life and development of a questionnaire to compose common toxicity criteria grading for use in daily clinical practice. Supportive Care in Cancer. 2016 Jun 3;24(6):2411–20.
DOI: https://doi.org/10.1007/s00520-015-3032-y
Kazamel M, Dyck PJ. Sensory manifestations of diabetic neuropathies. Prosthet Orthot Int. 2015 Feb;39(1):7–16.
DOI: https://doi.org/10.1177/0309364614536764
Alam U, Riley DR, Jugdey RS, Azmi S, Rajbhandari S, D’Août K, et al. Diabetic Neuropathy and Gait: A Review. Diabetes Therapy. 2017 Dec 1;8(6):1253–64.
DOI: https://doi.org/10.1007/s13300-017-0295-y
Riandini T, Khoo EYH, Tai BC, Tavintharan S, Phua MSLA, Chandran K, et al. Fall Risk and Balance Confidence in Patients With Diabetic Peripheral Neuropathy: An Observational Study. Front Endocrinol (Lausanne). 2020 Oct 23;11.
DOI: https://doi.org/10.3389/fendo.2020.573804
Ahmad I, Verma S, Noohu MM, Hussain MohdE. Effect of sensorimotor training on spatiotemporal parameters of gait among middle and older age adults with diabetic peripheral neuropathy. Somatosens Mot Res. 2021 Jul 3;38(3):230–40.
DOI: https://doi.org/10.1080/08990220.2021.1955671
Bruschi LKM, da Rocha DA, Filho ELG, Barboza N de MP, Frisanco PAB, Callegaro RM, et al. Diabetes Mellitus and Diabetic Peripheral Neuropathy. Open J Endocr Metab Dis. 2017;07(01):12–21.
DOI: https://doi.org/10.4236/ojemd.2017.71002
Rahman MdM, Sultana H, Jebin FM, Saha T, Yasmeen W, Alom FMM, et al. Health Related Quality of Life in Adult with Type 2 Diabetes Mellitus. J Diabetes Mellitus. 2022;12(04):243–51.
DOI: https://doi.org/10.4236/jdm.2022.124019
Öztürk B, Angın E, Güçhan Z, Yurt Y, Malkoç M. Assessment of the Plantar Pressure, Muscle Strength and Balance in Patients with Type 2 Diabetes Mellitus in Cyprus. Open J Endocr Metab Dis. 2016;06(05):151–8.
DOI: https://doi.org/10.4236/ojemd.2016.65020
Nomura T, Ishiguro T, Ohira M, Ikeda Y, Watanabe M. Multicenter Survey of the Isometric Lower Extremity Strength in Patients with Type 2 Diabetes (MUSCLE-std): Design and Study Protocol. J Diabetes Mellitus. 2014;04(04):251–6.
DOI: https://doi.org/10.4236/jdm.2014.44036
How to Cite
Imamah, I. N., Setiani, D., Firdaus, R., Shoufiyah, R., Rizal, A. A. F., & Ifroh, R. H. (2024). Correlation of nerve damage and peripheral neuropathy incidence using the MNSI and MDNS instrument approaches. Healthcare in Low-Resource Settings, 12(1). https://doi.org/10.4081/hls.2024.11732
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