https://doi.org/10.4081/hls.2023.11340
The effect of vitamin D deficiency on glycemic control in patients with type 2 diabetes mellitus
Submitted: 27 March 2023
Accepted: 3 May 2023
Published: 8 June 2023
Accepted: 3 May 2023
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All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Authors
Multiple factors are involved in the development of type 2 diabetes mellitus (T2DM), but an imbalance between free radical formation and antioxidant removal is the main cause of diabetic complications. Micronutrients with antioxidant properties may have a role in the development of diabetes mellitus (DM) and its complications. Vitamin D has recently been found to have membrane antioxidant effect and a relationship to the development of T2DM, as it can modify its risk. Whether vitamin D deficiency has an effect on hyperglycemia in diabetic patients or not need further study. Our aim was to examine the effect of vitamin D deficiency on glycemic control in T2DM. We examined the vitamin D levels of 100 patients with T2DM and correlated them with fasting blood sugar and glycated hemoglobin A1c (HbA1c) levels. High levels of fasting blood sugar and HbA1c levels were significantly associated with vitamin D deficiency. Vitamin D deficiency negatively affects glycemic control in patients with T2DM.
Ogurtsova K, Rocha J, Fernandes D, et al. IDF Diabetes Atlas: Global estimates for the prevalence of diabetes for 2015 and 2040. Diabetes Res Clinical Pract 2017;128:40-50.
DOI: https://doi.org/10.1016/j.diabres.2017.03.024
Latif A, Anwar S, Gautham K, et al. Association of Plasma Omentin-1 Levels With Diabetes and Its Complications. Cureus 2021;13:e18203.
Kocak Z, Aktas G, Atak B, et al. Is Neuregulin-4 a predictive marker of microvascular complications in type 2 diabetes mellitus? Eur J Clin Invest 2020;50:e13206.
DOI: https://doi.org/10.1111/eci.13206
Aktas G, Alcelk A, Tosun M, et al. Diabetes mellitus increases plasma cardiothrophin-1 levels independently of heart failure and hypertension. Acta Med Mediterr 2013;29:78.
Liu W, Lou X, Zhang Z, et al. Association of neutrophil to lymphocyte ratio, platelet to lymphocyte ratio, mean platelet volume with the risk of gestational diabetes mellitus. Gynacol Endocrinol 2021;37:105-7.
DOI: https://doi.org/10.1080/09513590.2020.1780579
Bilgin S, Aktaş G, Kahveci G, et al. Does mean platelet volume/lymphocyte count ratio associate with frailty in type 2 diabetes mellitus? Bratisl Lek Listy 2021;122:116-9.
DOI: https://doi.org/10.4149/BLL_2021_017
Bilgin S, Kurtkulagi O, Atak B, et al. Does C-reactive protein to serum Albumin Ratio correlate with diabEtic nephropathy in patients with Type 2 dIabetes MEllitus? The CARE TIME study. Primary Care Diab 2021;15:1071-4.
DOI: https://doi.org/10.1016/j.pcd.2021.08.015
Aktas G, Kocak M, Bilgin S, et al. Uric acid to HDL cholesterol ratio is a strong predictor of diabetic control in men with type 2 diabetes mellitus. Aging Male 2020;23:1098-102.
DOI: https://doi.org/10.1080/13685538.2019.1678126
Pasquali M, Tartaglione L, Rotondi S, et al. Calcitriol/calcifediol ratio: An indicator of vitamin D hydroxylation efficiency? BBA Clin 2015;3:251-6.
DOI: https://doi.org/10.1016/j.bbacli.2015.03.004
Zatalia R, Sanusi H. The role of antioxidants in the pathophysiology, complications, and management of diabetes mellitus. Acta Med Indones 2013;45:141–7.
Erkus E, Aktas G, Atak B, et al. Haemogram Parameters in Vitamin D Deficiency. J College Phys Surg Pak 2018;28:779-82.
Vujosevic S, Borozan S, Radojevic N, et al. Relationship between 25-hydroxyvitamin D and newly diagnosed type 2 diabetes mellitus in postmenopausal women with osteoporosis. Med Princ Pract 2014;23:229–33.
DOI: https://doi.org/10.1159/000360540
American Diabetes Association. Classification and diagnosis of diabetes: standards of medical care in diabetes 2018. Diabetes Care 2018;41:S13–S27.
DOI: https://doi.org/10.2337/dc18-S002
Peterkova VA, Vasyukova OV. About the new classification of obesity in the children and adolescents. Problems Endocrinol 2015;61:39-44.
DOI: https://doi.org/10.14341/probl201561239-44
Doust J, Glasziou P. Monitoring in clinical biochemistry. Clin Biochem Rev 2013;34:85-92.
Shan I, Aktar M, Hisaindee S, et al. Clinical diagnostic tools for vitamin D assessment. J Steroid Biochem Mol Biol 2018;180:105-17.
DOI: https://doi.org/10.1016/j.jsbmb.2017.10.003
Karau P, Kima B, Amayo E, et al. The prevalence of vitamin D deficiency among patients with type 2 diabetes seen at a referral hospital in Kenya. Pan Afr Med J 2019;34:8.
DOI: https://doi.org/10.11604/pamj.2019.34.38.18936
Al-Humaidi M, Agha A, Dewish M. Vitamin D deficiency in patients with type 2 diabetes mellitus in southern region of Saudi Arabia. Maedica 2013;8:231-6.
A-Zaharani M. The prevalence of vitamin D deficiency in type 2 diabetic patients. Majmaah J Health Sci 2013;1:18-22.
DOI: https://doi.org/10.12816/0004767
Zhao H, Zhen Y, Wang Z, et al. The relationship between vitamin D deficiency and glycated hemoglobin levels in patients with type 2 diabetes mellitus. Diabetes Metab Syndr Obes 2020;13:3899-907.
DOI: https://doi.org/10.2147/DMSO.S275673
Szymczak-Pajor I, Sliwinska A. Analysis of association between vitamin D deficiency and insulin resistance. Nutrient 2019;11:794.
DOI: https://doi.org/10.3390/nu11040794
Al Quaiz A, Al Rasheed A, Kazi A, et al. Is hydroxyvitamin D associated with glycosylated hemoglobin in patients with type 2 diabetes mellitus in Saudi Arabia? A population based study. Int J Environ Res Puplic Health 2021;18:2805.
DOI: https://doi.org/10.3390/ijerph18062805
Erkus E, Aktas G, Kocak MZ, et al. Diabetic regulation of subjects with type 2 diabetes mellitus is associated with serum vitamin D levels. Rev Assoc Med Bras (1992) 2019;65:51-55.
DOI: https://doi.org/10.1590/1806-9282.65.1.51
Mohamed I, Elsherbeny E, Bekhet M. The effect of vitamin D supplementation on glycemic control and lipid profile in patients with type 2 diabetes mellitus. J Am CollNutr 2016;35:399-404.
DOI: https://doi.org/10.1080/07315724.2015.1026427
Lemieux P, Weisnagel J, Caron Z, et al. Effect of 6 months vitamin D supplementation on insulin sensitivity and secretion in a randomized placebo- controlled trial. Eur J Endocrinol 2019;181:287-99.
DOI: https://doi.org/10.1530/EJE-19-0156
Kumar A, Nada K, Bharathy N, et al. Evaluation of vitamin D status and its correlation with glycated hemoglobin in type 2 diabetes mellitus. Biomed Res 2017;28:66-70.
Li X, Liu Y, Zheng Y, et al. The effect of vitamin D supplementation on glycemic control in type 2 diabetic patients: A systemic review and meta-analysis. Nutrients 2018;10:375.
DOI: https://doi.org/10.3390/nu10030375
Valdes-Ramos R, Lopez Ana Laura G, Elina M, Donaji B. Vitamins and type 2 diabetes mellitus. Endocr Metab Immne Disord Drug Targets 2015;15:54-63.
DOI: https://doi.org/10.2174/1871530314666141111103217
How to Cite
Rashad Mostafa, N., Ali, A. A. M., & Marzo, R. R. (2023). The effect of vitamin D deficiency on glycemic control in patients with type 2 diabetes mellitus. Healthcare in Low-Resource Settings, 11(s2). https://doi.org/10.4081/hls.2023.11340
Copyright (c) 2023 the Author(s)
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
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