https://doi.org/10.4081/hls.2023.11323
Value of biochemical markers in predicting outcome of COVID-19 infection in University Hospital, Alexandria, Egypt
Submitted: 18 March 2023
Accepted: 2 May 2023
Published: 8 June 2023
Accepted: 2 May 2023
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All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Authors
This paper aims to examine the value of different biochemical markers in predicting the outcome of COVID-19 infection. A total of 140 patients with confirmed COVID-19 infection by polymerase chain reaction (PCR), different biochemical markers were tested, their relation to the outcome of the disease was monitored, and the most reliable tests were determined. The study found a significant correlation between all evaluated biochemical markers and severity of the disease, including C-reactive protein (CRP), D-dimer, alanine aminotransferase (ALT), Aspartate aminotransferase (AST), prothrombin time (PT), activated partial thromboplastin time (aPTT). In addition, ferritin, lactate dehydrogenase (LDH), procalcitonin (PCT) and Pro- Brain natriuretic peptide (proBNP) demonstrated highly sensitivity and specificity as well as significant prognostic performance. These markers were also independently significant in predicting mortality. Early assessment of biochemical markers in patients with COVID-19 can help clinicians in tailoring treatment and providing more intensive care to those with greater mortality risk. In particular, the assessment of ferritin, LDH, procalcitonin and proBNP can independently predict mortality.
Lu R, Zhao X, Li J. Genomic characterization and epidemiology of 2019 novel coronavirus: implication for virus origins and receptor binding. Lancet 2020;395:565-74.
DOI: https://doi.org/10.1016/S0140-6736(20)30251-8
Chen T, Wu D, Chen H, Yan W, Yang D. Clinical characteristics of 113 deceased patients with coronavirus disease 2019: retrospective study. BMJ.2020; 368: m1091.
DOI: https://doi.org/10.1136/bmj.m1091
Hariyanto I and Kurniawan A. Thyroid disease is associated with severe corona disease 2019 (COVID-19) infection. Diabetes Metab Syndr 2020;14:1429-30.
DOI: https://doi.org/10.1016/j.dsx.2020.07.044
Liu Y, Yang Y, Zhang C, et al. Clinical and biochemical indexes from 2019-nCoV infected patients linked to viral loads and lung injury. Science China. Life Sciences 2020;63:364–74.
DOI: https://doi.org/10.1007/s11427-020-1643-8
Hariyanto T, Japar K, Kwenandar F, et al. Inflammatory and hematologic markers as predictors of severe outcomes in COVID-19 infection: A systematic review and meta-analysis. Am J Emerg Med 2021;41:110–9.
DOI: https://doi.org/10.1016/j.ajem.2020.12.076
Kubina R, Dziedzic A. Molecular and serological tests for COVID-19 a comparative review of SARS-CoV-2 coronavirus laboratory and point-of-care diagnostics. Diagnostics 2020;10:434.
DOI: https://doi.org/10.3390/diagnostics10060434
Letelier P, Encina N, Morales P, et al. Role of biochemical markers in the monitoring of COVID-19 patients. J Med Biochem 2012;40:115–28.
DOI: https://doi.org/10.5937/jomb0-29341
Centers of disease control and prevention (2020) COVID-19 (Coronavirus disease): people with certain medical conditions. 2020. Accessed August 31, 2021. Available from: https://www.cdc.gov/coronavirus/2019-ncov/need-extra-precautiona/people-with-medical-conditions.html
Chen T, Dai Z, Mo P, et al. Clinical Characteristics and Outcomes of Older Patients with Coronavirus Disease 2019 (COVID-19) in Wuhan, China: A Single-Centered, Retrospective Study. J Gerontol 2020;75:1788–95.
DOI: https://doi.org/10.1093/gerona/glaa089
Koyyada R, Nagalla B, Tummala A, et al. Prevalence and Impact of Preexisting Comorbidities on Overall Clinical Outcomes of Hospitalized COVID-19 Patients. BioMed Res Int 2022:2349890.
DOI: https://doi.org/10.1155/2022/2349890
Sharif N, Opu R, Ahmed S, et al. Prevalence and impact of comorbidities on disease prognosis among patients with COVID-19 in Bangladesh: A nationwide study amid the second wave. Diabetes Metab Syndr 2021;15:102148.
DOI: https://doi.org/10.1016/j.dsx.2021.05.021
Foresta C, Rocca S, Di Nisio A. Gender susceptibility to COVID-19: a review of the putative role of sex hormones and X chromosome. J Endocrinol Invest 2021;44:951–6.
DOI: https://doi.org/10.1007/s40618-020-01383-6
Davies G, Klepac P, Liu Y, et al. Age-dependent effects in the transmission and control of COVID-19 epidemics. Nature Med 2020;26:1205-11.
DOI: https://doi.org/10.1038/s41591-020-0962-9
Kalra L, Smith C, Hodsoll J, et al. Elevated C-reactive protein increases diagnostic accuracy of algorithm-defined stroke-associated pneumonia in afebrile patients. Int J Stroke 2019;14:167-73.
DOI: https://doi.org/10.1177/1747493018798527
Xu J, Xu C, Zhang R, et al. Associations of procalcitonin, C-reaction protein and neutrophil-to-lymphocyte ratio with mortality in hospitalized COVID-19 patients in China. Sci Rep 2020;10:1-10.
DOI: https://doi.org/10.1038/s41598-020-72164-7
Rosário C, Zandman-Goddard G, Meyron-Holtz G, et al. The hyperferritinemic syndrome: macrophage activation syndrome, Still’s disease, septic shock and catastrophic antiphospholipid syndrome. BMC Med 2013;11:1-11.
DOI: https://doi.org/10.1186/1741-7015-11-185
Ji D, Zhang S, Chen Z, et al. Clinical characteristics predicting progression of COVID-19 (2/17/2020). Available at SSRN 3539674.
DOI: https://doi.org/10.2139/ssrn.3539674
Hou F, Yu T, Du R, et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet 2020;395:1054–62.
Henry M, Aggarwal G, Wong J, et al. Lactate dehydrogenase levels predict coronavirus disease 2019 (COVID-19) severity and mortality: A pooled analysis. Am J Emerg Med 2020;38:1722–26.
DOI: https://doi.org/10.1016/j.ajem.2020.05.073
Martha W, Wibowo A, Pranata R. Prognostic value of elevated lactate dehydrogenase in patients with COVID-19: a systematic review and meta-analysis. Postgrad Med J 2022;98:422–7.
DOI: https://doi.org/10.1136/postgradmedj-2020-139542
Szarpak L, Ruetzler K, Safiejko K, et al. Lactate dehydrogenase level as a COVID-19 severity marker. Am J Emerg Med 2021;45:638–9.
DOI: https://doi.org/10.1016/j.ajem.2020.11.025
Mikacenic C, Hahn O, Price L, et al. Biomarkers of Endothelial Activation Are Associated with Poor Outcome in Critical Illness. PLoS One 2015;10:e0141251.
DOI: https://doi.org/10.1371/journal.pone.0141251
Lippi G, Favaloro E. D-dimer is Associated with Severity of Coronavirus Disease 2019: A Pooled Analysis. Thrombosis Haemostasis 2020;120:876–8.
DOI: https://doi.org/10.1055/s-0040-1709650
Wang D, Hu B, Hu C, et al. Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus–infected pneumonia in Wuhan, China. JAMA 2020;323:1061-9.
DOI: https://doi.org/10.1001/jama.2020.1585
Zhou F, Yu T, Du R, et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet 2020;395:1054–62.
DOI: https://doi.org/10.1016/S0140-6736(20)30566-3
Hui S, Memish A, Zumla A. Severe acute respiratory syndrome vs. the Middle East respiratory syndrome. Curr Opin Pulm Med 2014;20:233-41.
DOI: https://doi.org/10.1097/MCP.0000000000000046
Chen N, Zhou M, Dong X, et al. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. Lancet 2020;395:507–13.
DOI: https://doi.org/10.1016/S0140-6736(20)30211-7
Lei F, Liu M, Zhou F, et al. Longitudinal Association Between Markers of Liver Injury and Mortality in COVID-19 in China. Hepatology 2020;72:389–98.
DOI: https://doi.org/10.1002/hep.31301
Jackson P, Darbousset R, Schoenwaelder M. Thromboinflammation: challenges of therapeutically targeting coagulation and other host defense mechanisms. Blood 2019;133:906–18.
DOI: https://doi.org/10.1182/blood-2018-11-882993
Mierzchała-Pasierb M, Lipińska-Gediga M. Sepsis diagnosis and monitoring - procalcitonin as standard, but what next? Anaesthesiol Intensive Ther 2019;51:299-305.
DOI: https://doi.org/10.5114/ait.2019.88104
How to Cite
Rashad Mostafa, N., Ali, A. A. M., Ezzat, R. M., Bakry, M. K., & Marzo, R. R. (2023). Value of biochemical markers in predicting outcome of COVID-19 infection in University Hospital, Alexandria, Egypt. Healthcare in Low-Resource Settings, 11(s2). https://doi.org/10.4081/hls.2023.11323
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