https://doi.org/10.4081/gc.2021.9338

Role of high dose IV vitamin C and zinc in coronavirus

Vol. 7 No. 1 (2021)
Submitted: 5 September 2020
Accepted: 14 January 2021
Published: 19 February 2021
COVID-19, SARS-CoV-2, vitamin C, zinc, treatment.
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Authors

Arooj Fatima
Department of Pharmacology University of Health Sciences, Lahore, Pakistan.
Muhammad Usman Ali Khan
Department of Pharmacology University of Health Sciences, Lahore, Pakistan.
Mehkaar Najeeb
Department of Physiology, University of Health Sciences, Lahore, Pakistan.
Muhammad Yasoob Ali Khan
Combined Miltary Hospital, Multan, Pakistan, Pakistan.
Faiz Ul Haq
faizulhaq553@gmail.com
Department of Microbiology, University of Health Sciences, Lahore, Pakistan.

Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome- related coronavirus 2 (SARS-CoV- 2), is now considered as an ongoing global pandemic. Common symptoms include pyrexia, cough, dyspnea, fatigue, sore throat, and loss of sense of taste and smell. Complications that can result from more severe insult on lung tissue is pneumonia and acute respiratory distress syndrome (ARDS), which can further lead to septic shock. It is also not uncommon to find neurological symptoms in patients suffering from COVID-19. The primary treatment for COVID-19 is symptomatic treatment and supportive care. As there is no known vaccination and antiviral therapy for this disease, there is a desperate need to find an alternative to control and stop the spread of disease. Maintaining adequate micronutrient balance might enhance the immunity and protect from viral infections as well. Vitamin C and zinc helps in improving symptoms and shortening the duration of the common cold. Vitamin C (L-ascorbic acid) possesses pleiotropic physiological activity. High dose Vitamin C has shown to be effective against the common flu, rhinovirus, avian virus, chikungunya, Zika, ARDS, and influenza, and there is evidence that supports the protective effect of high dose IV vitamin C during sepsis-induced ARDS due to COVID-19. Zinc has a profound impact on the replication of viruses. Increasing intracellular zinc concentration along with pyrithione (zinc ionophore) has been shown to impair the replication of several RNA viruses efficiently, including poliovirus, influenza virus and several picornaviruses. A combination of zinc and can also inhibit the replication of SARS-coronavirus in cell culture.

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Citations

Crossref
Scopus
Google Scholar
Europe PMC
Haq FU, Roman M, Ahmad K, et al. Artemisia annua: trials are needed for COVID‐19. Phytother Res 2020 [Epub ahead of print].
Haq FU, Khan MU, Muazzam A, et al. Interferon-β: treatment option against COVID-19. Geriatric Care 2020 [Epub ahead of print].
Khan MU, Muazzam A, Farooq H, et al. Interferon-β: treatment option against COVID-19. Geriatric Care 2020;6:9093.
Wimalawansa SJ. Global epidemic of coronavirus - COVID-19: what can we do to minimize risks. Eur J Biomed 2020;7:432-8.
Kakodkar P, Kaka N, Baig M. A comprehensive literature review on the clinical presentation, and management of the pandemic coronavirus disease 2019 (COVID-19). Cureus 2020;12:4. DOI: https://doi.org/10.7759/cureus.7560
World Health Organization. Coronavirus disease (‎‎COVID-19)‎‎: situation report, 150; 2020. Retrieved on 20 June 2020. https://www.who.int/emergencies/diseases/novel-coronavirus-2019/situationreports
Sargsyan K, Chen T, Grauffel C, Lim C. Targeting 2019 novel coronavirus with clinically safe Zn-ejector drugs. Preprints 2020 [Epub ahead of print].
Coleman CM, Frieman MB. Coronaviruses: important emerging human pathogens. J Virol 2014;88:5209-12. DOI: https://doi.org/10.1128/JVI.03488-13
Romero-Sánchez CM, Díaz-Maroto I, Fernández-Díaz E, et al. Neurologic manifestations in hospitalized patients with COVID-19: The ALBACOVID registry. Neurology 2020 [Epub ahead of print]. DOI: https://doi.org/10.1212/WNL.0000000000009937
Wu Y, Xu X, Chen Z, et al. Nervous system involvement after infection with COVID-19 and other coronaviruses. Brain Behav Immun 2020 [Epub ahead of print]. DOI: https://doi.org/10.1016/j.bbi.2020.03.031
Ye M, Ren Y, Lv T. Encephalitis as a clinical manifestation of COVID-19. Brain Behav Immun 2020 [Epub ahead of print]. DOI: https://doi.org/10.1016/j.bbi.2020.04.017
Zhang L, Liu Y. Potential interventions for novel coronavirus in China: a systemic review. J Med Virol 2020 [Epub ahead of print].
Colunga Biancatelli RML, Berrill M, Marik PE. The antiviral properties of vitamin C. New York: Taylor & Francis; 2020.
Erol A. High-dose intravenous vitamin C treatment for COVID-19. Preprints 2020 [Epub ahead of print]. DOI: https://doi.org/10.31219/osf.io/p7ex8
Wintergerst ES, Maggini S, Hornig DH. Immune-enhancing role of vitamin C and zinc and effect on clinical conditions. Ann Nutr Metab 2006;50:85-94. DOI: https://doi.org/10.1159/000090495
Ewer T, Lewis G. Intravenous vitamin C and the treatment of infections. J Austral Coll Nutr Environ Med 2011;30:8.
Carr AC, Maggini S. Vitamin C and immune function. Nutrients 2017;9:1211. DOI: https://doi.org/10.3390/nu9111211
Englard S, Seifter S. The biochemical functions of ascorbic acid. Annu Rev Nutr 1986;6:365-406. DOI: https://doi.org/10.1146/annurev.nu.06.070186.002053
Mandl J, Szarka A, Banhegyi G. Vitamin C: update on physiology and pharmacology. Br J Pharmacol 2009;157:1097-110. DOI: https://doi.org/10.1111/j.1476-5381.2009.00282.x
Zhang L, Liu Y. Potential interventions for novel coronavirus in China: A systematic review. J Med Virol 2020;92:479-90. DOI: https://doi.org/10.1002/jmv.25707
Mikirova NA, Hunninghake R. Effect of high dose vitamin C on Epstein-Barr viral infection. Med Sci Monitor 2014;20:725. DOI: https://doi.org/10.12659/MSM.890423
Biancatelli RC, Berrill M, Marik PE. The antiviral properties of vitamin C. Exp Rev Anti-Infect Ther 2020;18:99-101. DOI: https://doi.org/10.1080/14787210.2020.1706483
Kim G-N, Yoo W-S, Park M-H, et al. Clinical features of herpes simplex keratitis in a Korean tertiary referral center: efficacy of oral antiviral and ascorbic acid on recurrence. Korean J Ophthalmol 2018;32:353-60. DOI: https://doi.org/10.3341/kjo.2017.0131
Byun SH, Jeon Y. Administration of vitamin C in a patient with herpes zoster-a case report. Korean J Pain 2011;24:108. DOI: https://doi.org/10.3344/kjp.2011.24.2.108
Read SA, Obeid S, Ahlenstiel C, Ahlenstiel G. The role of zinc in antiviral immunity. Adv Nutr 2019;10:696-710. DOI: https://doi.org/10.1093/advances/nmz013
Kaushik N, Subramani C, Anang S, et al. Zinc salts block hepatitis E virus replication by inhibiting the activity of viral RNA-dependent RNA polymerase. J Virol 2017;91:21. DOI: https://doi.org/10.1128/JVI.00754-17
Mousa HA-L. Prevention and treatment of influenza, influenza-like illness, and common cold by herbal, complementary, and natural therapies. J Evid-Based Complement Alternat Med 2017;22:166-74. DOI: https://doi.org/10.1177/2156587216641831
Singh M, Das RR. Clinical potential of zinc in prophylaxis of the common cold. Exp Rev Respir Med 2011;5:301-3. DOI: https://doi.org/10.1586/ers.11.29
Qiu M, Chen Y, Chu Y, et al. Zinc ionophores pyrithione inhibits herpes simplex virus replication through interfering with proteasome function and NF-κB activation. Antiviral Res 2013;100:44-53. DOI: https://doi.org/10.1016/j.antiviral.2013.07.001
Rodrigues da Silva M, Schapochnik A, Peres Leal M, et al. Beneficial effects of ascorbic acid to treat lung fibrosis induced by paraquat. PLoS One 2018;13:e0205535. DOI: https://doi.org/10.1371/journal.pone.0205535
Kashiouris MG, L’Heureux M, Cable CA, et al. The emerging role of vitamin C as a treatment for sepsis. Nutrients 2020;12:292. DOI: https://doi.org/10.3390/nu12020292
Zabetakis I, Lordan R, Norton C, Tsoupras A. COVID-19: the inflammation link and the role of nutrition in potential mitigation. Nutrients 2020;12:1466. DOI: https://doi.org/10.3390/nu12051466
Razzaque M. COVID-19 pandemic: Can maintaining optimal zinc balance enhance host resistance? Preprints 2020 [Epub ahead of print]. DOI: https://doi.org/10.20944/preprints202004.0006.v1

How to Cite

Fatima, A., Khan, M. U. A., Najeeb, M., Ali Khan, M. Y., & Haq, F. U. (2021). Role of high dose IV vitamin C and zinc in coronavirus. Geriatric Care, 7(1). https://doi.org/10.4081/gc.2021.9338

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