https://doi.org/10.4081/gc.2022.10390

Glutathione: pharmacological aspects and implications for clinical use

Vol. 8 No. 2 (2022)
Submitted: 30 January 2022
Accepted: 27 September 2022
Published: 30 September 2022
Glutathione, aging, frailty.
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Authors

Andrea Novelli
Department of Health Sciences, Clinical Pharmacology and Oncology Section, University of Firenze, Italy.
Angelo Bianchetti
angelo.bianchetti.58@gmail.com
Medicine and Rehabilitation Department, Istituto Clinico S. Anna Hospital, Gruppo San Donato, Brescia, Italy; and University of Brescia, Brescia, Italy.

Glutathione is a tripeptide found in many tissues which plays a pivotal role in critical physiological processes such as maintenance of redox balance, reduction of oxidative stress by enhancement of metabolic detoxification of both xenobiotic and endogenous compounds, and regulation of immune system function. Glutathione depletion is associated with many chronic degenerative diseases and loss of function with aging and altered glutathione metabolism has been implicated in central nervous system diseases, frailty and sarcopenia, infected state, chronic liver diseases, metabolic diseases, pulmonary and cardiovascular diseases. Therefore, the glutathione status may be an important biomarker and treatment target in various chronic, age-related diseases. Here we describe the main pharmacological aspects of glutathione, focusing on its synthesis and role in several vital functions including antioxidant defense, detoxification of xenobiotics and modulation of immune function and fibrogenesis and the clinical implications of its depletion and we discuss the different strategies for increasing glutathione cellular levels either by providing specific precursors and cofactors or directly administering the tripeptide.

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How to Cite

Novelli, A., & Bianchetti, A. (2022). Glutathione: pharmacological aspects and implications for clinical use. Geriatric Care, 8(2). https://doi.org/10.4081/gc.2022.10390

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