https://doi.org/10.4081/ecj.2020.9105

Immunodepression COVID-19-related as a promoting factor for severe Pseudomonas sepsis in an infant with not respiratory symptoms

Vol. 16 No. 3 (2020)
Submitted: 13 May 2020
Accepted: 12 November 2020
Published: 8 January 2021
COVID-19, children, sepsis, diarrhea, fever
Abstract Views: 660
PDF: 304
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Authors

Letizia Zenzeri
zenzeriletizia@gmail.com
https://orcid.org/0000-0001-5220-680X
Pediatric Emergency Unit, Santobono-Pausilipon Children’s Hospital, Italy.
Antonietta Giannattasio
Pediatric Emergency Unit, Santobono-Pausilipon Children’s Hospital, Italy.
Geremia Zito Marinosci
Pediatric Intensive Care Unit, Santobono-Pausilipon Children’s Hospital, Naples, Italy.
Eduardo Ponticiello
Pediatric Emergency Unit, Santobono-Pausilipon Children’s Hospital, Italy.
Margherita Raffaella Iodice
Maria Erennia Vitullo
Pediatric Intensive Care Unit, Santobono-Pausilipon Children’s Hospital, Naples, Italy.
Vincenzo Tipo
https://orcid.org/0000-0001-8159-2359
Pediatric Emergency Unit, Santobono-Pausilipon Children’s Hospital, Italy.

The outbreak of coronavirus disease 2019 caused by severe acute respiratory syndrome coronavirus 2 is a reason of concern worldwide. While a high proportion of adult patients have been severely ill, requiring intensive care assistance and mechanical ventilation, pediatric patients seem to have a less invasive clinical expression of the disease. Reasons for a milder disease in children compared to that seen in adults are yet to be elucidated. Nonetheless, severe and fatal cases have been reported in children and are expected to continue to increase with the growing community transmission and overall current disease prevalence. We report the first case of an infant with a very mild not-respiratory COVID- 19 infection and a concomitant invasive bacterial sepsis.

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Crossref
Scopus
Google Scholar
Europe PMC
Remuzzi A, Remuzzi G. COVID-19 and Italy: what next? Lancet 2020;395(10231):1225-8.
Zhang YH, Lin DJ, Xiao MF, et al. [2019 novel coronavirus infection in a three-month-old baby]. Zhonghua Er Ke Za Zhi 2020;58(3):182-184.
Yonker LM, Neilan AM, Bartsch Y, et al. Pediatric SARS-CoV-2: Clinical Presentation, Infectivity, and Immune Responses. J Pediatr. 2020; S0022-3476(20)31023-4.
Diao, B., Wang, C., Tan, Y., et al. Reduction and Functional Exhaustion of T Cells in Patients with Coronavirus Disease 2019 (COVID-19). Front Immunol 2020;11:827.
Yaqinuddin A, Kashir J. Innate immunity in COVID-19 patients mediated by NKG2A receptors, and potential treatment using monalizumab, choloroquine, and antiviral agents. Med Hypotheses 2020;140:109777.
Weiss SL, Peters MJ, Alhazzani W, et al. Surviving Sepsis Campaign International Guidelines for the Management of Septic Shock and Sepsis-Associated Organ Dysfunction in Children. Pediatr Crit Care Med. 2020;21(2):e52-e106.
Chen ZM, Fu JF, Shu Q. New Coronavirus: new Challenges for Pediatricians. World J Pediatr. 2020;10;1.
Sun D, Li H, Lu X, et al. Clinical features of severe pediatric patients with coronavirus disease 2019 in Wuhan: a single center’s observational study. World J Pediatr 2020;1-9.
Cai JH, Wang XS, Ge YL, et al. [First case of 2019 novel coronavirus infection in children in Shanghai]. Zhonghua Er Ke Za Zhi. 2020;58(2):86-87.
Cai J, Xu J, Lin D, et al. A Case Series of children with 2019 novel coronavirus infection: clinical and epidemiological features. Clin Infect Dis. 2020. ciaa198.
Li H, Liu L, Zhang D, et al. SARS-CoV-2 and viral sepsis: observations and hypotheses. Lancet. 2020; 395:1517-20.
Huang C, Wang Y, Li X, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020; 395(10223):497-506.
Jones SA, Jenkins BJ. Recent insights into targeting the IL-6 cytokine family in inflammatory diseases and cancer. Nat Rev Immunol. 2018;18(12):773-789.
Fielding CA, Jones GW, McLoughlin RM, et al. Interleukin-6 signaling drives fibrosis in unresolved inflammation. Immunity. 2014;40(1):40-50.
Chuang CH, Janapatla RP, Wang YH, et al. Pseudomonas aeruginosa-associated Diarrheal Diseases in Children. Pediatr Infect Dis J. 2017;36(12):1119-23.
Coronado Munoz A, Nawaratne U, McMann D, et al. Late-Onset Neonatal Sepsis in a Patient with Covid-19. N Engl J Med. 2020; 382(19):e49.
Kamali Aghdam M, Jafari N, Eftekhari K. Novel coronavirus in a 15-day-old neonate with clinical signs of sepsis, a case report. Infect Dis (Lond) 2020; 52(6):427-429.

How to Cite

Zenzeri, L., Giannattasio, A., Zito Marinosci, G., Ponticiello, E., Iodice, M. R., Vitullo, M. E., & Tipo, V. (2021). Immunodepression COVID-19-related as a promoting factor for severe <i>Pseudomonas sepsis<i> in an infant with not respiratory symptoms. Emergency Care Journal, 16(3). https://doi.org/10.4081/ecj.2020.9105

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