That purplish huge hole on the chest wall

Published: 23 August 2024
Abstract Views: 1780
PDF: 263
Publisher's note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.

Authors

A 54-year-old woman presented to our emergency department two months after the removal by Video-Assisted Thoracoscopic Surgery (VATS) of her middle lung lobe affected by severe inflammation and fibrosis. She was experiencing pain from a large ulcer (diameter 13 cm) starting from the surgical scar. She suffered from Calcinosis, Raynaud phenomenon, Esophageal dysmotility, Sclerodactyly, and Telangiectasia (CREST) syndrome, and hypothyroidism. The laboratory results showed White Blood Cell count (WBC) 13,600/mm3 (N 76%), C-Reactive Protein (CRP) 12 mg/L (nv<6), and Erythrocyte Sedimentation Rate (ESR) 86 mm/h (nv<20). Repeat skin swabs were always negative. Skin biopsy documented granulocyte infiltration in the dermis-hypodermis with tissue necrosis. For three weeks, the patient was treated with methylprednisolone 1 mg/Kg IV and colchicine 0.5 mg q12h orally. In the absence of a good response, oral cyclosporine 75 mg q12h was added. The ulcer gradually improved within a week. The pain was successfully treated with paracetamol 1 gr q8h IV.

Dimensions

Altmetric

PlumX Metrics

Downloads

Download data is not yet available.

Citations

Schmieder SJ, Krishnamurthy K. Pyoderma Gangrenosum. Available from: https://www.ncbi.nlm.nih.gov/books/NBK482223/
Ashchyan HJ, Butler DC, Nelson CA, et al. The association of age with clinical presentation and comorbidities of pyoderma gangrenosum. JAMA Dermatol. 2018;154:409-13. Erratum in: JAMA Dermatol. 2018;154:630. DOI: https://doi.org/10.1001/jamadermatol.2017.5978
Braswell SF, Kostopoulos TC, Ortega-Loayza AG. Pathophysiology of pyoderma gangrenosum (pg): an updated review. J Am Acad Dermatol. 2015;73:691-8. DOI: https://doi.org/10.1016/j.jaad.2015.06.021
Bissonnette C, Kauzman A, Mainville GN. Oral pyoderma gangrenosum: diagnosis, treatment and challenges: a systematic review. Head Neck Pathol. 2017;11:427-41. DOI: https://doi.org/10.1007/s12105-017-0804-3
Vaysse-Vic M, Mathieu PA, Charissoux A, et al. Pyoderma gangrenosum or necrotising fasciitis? Diagnostic and therapeutic wanderings. Orthop Traumatol Surg Res. 2017;103:615-7. DOI: https://doi.org/10.1016/j.otsr.2017.01.009
Kaffenberger BH, Hinton A, Krishna SG. The impact of underlying disease state on outcomes in patients with pyoderma gangrenosum: a national survey. J Am Acad Dermatol. 2018;79:659-63.e2. DOI: https://doi.org/10.1016/j.jaad.2018.02.007
Pichler M, Larcher L, Holzer M, et al. Surgical treatment of pyoderma gangrenosum with negative pressure wound therapy and split thickness skin grafting under adequate immunosuppression is a valuable treatment option: Case series of 15 patients. J Am Acad Dermatol. 2016;74:760-5. DOI: https://doi.org/10.1016/j.jaad.2015.09.009
Reichrath J, Bens G, Bonowitz A, Tilgen W. Treatment recommendations for pyoderma gangrenosum: an evidence based review of the literature based on more than 350 patients. J Am Acad Dermatol. 2005;53:273-83. DOI: https://doi.org/10.1016/j.jaad.2004.10.006

How to Cite

Rienzo, P., & Poggiali, E. (2024). That purplish huge hole on the chest wall. Emergency Care Journal. https://doi.org/10.4081/ecj.2024.12790