https://doi.org/10.4081/ecj.2022.10498

Anaemia, thrombocytopenia and skin lesions

Vol. 18 No. 2 (2022)
Published: 27 June 2022
Skin lesions, paraneoplastic pemphigus, haematology
Abstract Views: 933
PDF: 181
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Authors

Erika Poggiali
poggiali.erika@gmail.com
Emergency Department, Guglielmo da Saliceto Hospital, Piacenza, Italy.
Giorgio Orofino
Unit of Hematology and Bone Marrow Transplantation, IRCCS San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy.
Jacopo Peccatori
Unit of Hematology and Bone Marrow Transplantation, IRCCS San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy.

A 73-year-old man affected by hyperuricemia, dyslipidaemia and hypothyroidism presented to the emergency room with a 3-month history of fever, exertional dyspnea, progressive asthenia, and painless not itchy skin lesions. Physical exam showed purplish papules and plaques affecting any area of his body, and a slight bilateral oedema of his legs. Laboratory studies revealed a severe macrocytic anaemia (haemoglobin 4.8 g/dL, mean cell volume 119 fL) and thrombocytopenia (34,000/mm3) with hyperferritinemia (1894 ng/mL, normal value <400) and increased serum B12 (1412 pg/mL, normal value 197-771), associated with ESR 71 mm/h (normal value 1-15), CRP 139 mg/L (normal value <6), and procalcitonin 1.05 ng/mL (normal value <0.5).

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Europe PMC
Anhalt GJ, Kim SC, Stanley JR, et al. Paraneoplastic pemphigus. An autoimmune mucocutaneous disease associated with neoplasia. N Engl J Med 1990;323:1729-35. DOI: https://doi.org/10.1056/NEJM199012203232503
Ohzono A, Sogame R, Li X, et al. Clinical and immunological findings in 104 cases of paraneoplastic pemphigus. Br J Dermatol 2015;173:1447–52. DOI: https://doi.org/10.1111/bjd.14162
Lim JM, Lee SE, Seo J, et al. Paraneoplastic pemphigus associated with a malignant thymoma: a case of persistent and refractory oral ulcerations following thymectomy. Ann Dermatol 2017;29:219–22. DOI: https://doi.org/10.5021/ad.2017.29.2.219
Lee SE, Kim SC. Paraneoplastic pemphigus. Dermatol Sinica 2010;28:1–14. DOI: https://doi.org/10.1016/S1027-8117(10)60001-8
Lee J, Bloom R, Amber KT. A systematic review of patients with mucocutaneous and respiratory complications in paraneoplastic autoimmune multiorgan syndrome: castleman’s disease is the predominant malignancy. Lung 2015;193:593–6. DOI: https://doi.org/10.1007/s00408-015-9732-8
Kim JH, Kim SC. Paraneoplastic Pemphigus: Paraneoplastic Autoimmune Disease of the Skin and Mucosa. Front Immunol 2019;10:1259. DOI: https://doi.org/10.3389/fimmu.2019.01259
Chin AC, Stich D, White FV, et al. Paraneoplastic pemphigus and bronchiolitis obliterans associated with a mediastinal mass: a rare case of Castleman’s disease with respiratory failure requiring lung transplantation. J Pediatr Surg 2001;36:E22. DOI: https://doi.org/10.1053/jpsu.2001.28877

How to Cite

Poggiali, E., Orofino, G., & Peccatori, J. (2022). Anaemia, thrombocytopenia and skin lesions. Emergency Care Journal, 18(2). https://doi.org/10.4081/ecj.2022.10498

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