https://doi.org/10.4081/cdr.12.12689

Vitamin D deficiency and level of asthma control and severity in an adult population in Morocco

Vol. 12 (2024): Early Access
Submitted: 26 May 2024
Accepted: 14 June 2024
Published: 18 June 2024
Vitamin D deficiency, asthma severity, asthma control, adult
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Authors

Adil Zegmout
adilzgmt@gmail.com
https://orcid.org/0000-0003-2295-9629
Pulmonary Department, Mohammed V Military Hospital, Rabat; Faculty of Medicine and Pharmacy, Casablanca, Morocco.
Anis Rafik
Pulmonary Department, Mohammed V Military Hospital, Rabat, Morocco.
Hanane Asri
https://orcid.org/0000-0002-4442-832X
Pulmonary Department, Mohammed V Military Hospital, Rabat, Morocco.
Hicham Souhi
Pulmonary Department, Mohammed V Military Hospital, Rabat, Morocco.
Ismail Abderrahmane Rhorfi
Pulmonary Department, Mohammed V Military Hospital, Rabat, Morocco.
Hanane El Ouazzani
Pulmonary Department, Mohammed V Military Hospital, Rabat, Morocco.

Vitamin D plays a critical role in immune modulation, with implications for the severity and control of asthma. The study included 174 asthmatic patients aged 18-65 whose serum 25(OH)D3 levels and their relationship with asthma severity, control, and lung function were assessed. The prevalence of hypovitaminosis D was 64%, with 36.3% of patients having normal levels, 29.8% insufficient, and 33.9% deficient. Lower vitamin D levels were significantly associated with increased asthma severity (p=0.04) and poorer asthma control (p=0.03). Patients with severe asthma had mean 25(OH)D3 levels of 24.1±11.8 ng/mL, compared to 32.5±13.1 ng/mL in patients with non-severe asthma. Controlled asthma was linked with higher vitamin D levels (28.3±12.5 ng/mL) compared to partially controlled (24.7±10.8 ng/mL) and uncontrolled asthma (23.3±12.1 ng/mL). A non-significant trend was observed toward reduced Forced Expiratory Volume in One Second (FEV1) in vitamin D-deficient patients. Vitamin D deficiency is significantly associated with asthma control level and severity, underscoring the need for further research on the therapeutic potential of vitamin D in asthma management.

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How to Cite

Zegmout, A., Rafik, A., Asri, H., Souhi, H., Rhorfi, I. A., & El Ouazzani, H. (2024). Vitamin D deficiency and level of asthma control and severity in an adult population in Morocco. Chest Disease Reports, 12(1). https://doi.org/10.4081/cdr.12.12689
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