https://doi.org/10.4081/cdr.12.12626

Exfoliated dermatitis and hepatitis to first line Anti-Tubercular Therapy with treatment of Drug-Sensitive Tuberculosis with second line Anti-Tubercular Therapy: a roller coaster ride

Vol. 12 (2024): Early Access
Submitted: 30 April 2024
Accepted: 27 May 2024
Published: 3 June 2024
Exfoliated dermatitis, hepatitis, Anti-Tubercular Therapy, Drug-Sensitive Tuberculosis
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Authors

Sonam Spalgais
sosolrs@gmail.com
Department of Pulmonary Medicine, Vallabhbhai Patel Chest Institute, University of Delhi, India.
Ahmed Safwan M.
Department of Pulmonary Medicine, AIIMS Jodhpur, Rajastan, India.
Parul Mrigpuri
Department of Pulmonary Medicine, Vallabhbhai Patel Chest Institute, University of Delhi, India.
Raj Kumar
Department of Pulmonary Medicine, Vallabhbhai Patel Chest Institute, University of Delhi, India.

The Adverse Drug Reactions (ADRSs) to Anti-Tubercular Therapy (ATT) have been reported from 8% to 85% worldwide, while the prevalence of ADRSs to 1st line ATT from India reported 2.3% to 17%, with more during the intensive phase and daily regime. However, cutaneous ADRSs related to ATT are less commonly seen. Common cutaneous ADRSs are maculopapular rash, urticarial, erythema multiforme, exfoliative dermatitis, and Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS). Among the 1st line ATT, pyrazinamide is the most common cause at 2.38%, and isoniazid is reported the least at 0.98%. Exfoliated dermatitis is rarely seen with 1st line ATT therapy limited to some case reports and case series.

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How to Cite

Spalgais, S., Safwan M., A., Mrigpuri, P., & Kumar, R. (2024). Exfoliated dermatitis and hepatitis to first line Anti-Tubercular Therapy with treatment of Drug-Sensitive Tuberculosis with second line Anti-Tubercular Therapy: a roller coaster ride. Chest Disease Reports, 12(1). https://doi.org/10.4081/cdr.12.12626
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