https://doi.org/10.4081/cdr.11.11840

Metastatic intestinal adenocarcinoma arising within mature teratoma of the mediastinum: report of a surgically-resected case

Vol. 11 (2023)
Submitted: 19 September 2023
Accepted: 25 October 2023
Published: 25 October 2023
Mediastinal tumors, teratoma with malignant transformation, adenocarcinoma, metastases
Abstract Views: 1474
SUPPLEMENTARY PDF: 30
PDF: 67
Publisher's note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.

Authors

Yoldez Houcine
Pathology Department, Abderrahmen Mammi Hospital, Ariana; Faculty of Medicine, El Manar University, Tunisi, Tunisia.
Chirine Moussa
chirine.moussa22@gmail.com
Faculty of Medicine, El Manar University, Tunisi; Pneumology Department 1, Abderrahmen Mammi Hospital, Ariana, Tunisia.
Tarek Abid
Pasteur Clinic, Pneumology Department, Tunisi, Tunisia.
Sadok Hammami
Pasteur Clinic, Surgery Department, Tunisi, Tunisia.
Héla Skhiri
Pasteur Clinic, Oncology Department, Tunisi, Tunisia.
Aida Ayadi
Pathology Department, Abderrahmen Mammi Hospital, Ariana; Faculty of Medicine, El Manar University, Tunisi, Tunisia.

Intestinal adenocarcinoma spontaneously developing in an anterior mediastinal multilocular teratoma in a 33-year-old female is described. The patient has been experiencing chest distress for several months. On a chest X-ray, a cystic anterior mediastinal mass was identified. A subsequent computed tomography scan revealed a heterogeneous mass measuring 20x15x10 centimeters in the anterior right mediastinum. She underwent a median thoracotomy excision. The histopathologic examination revealed a mature teratoma with intestinal adenocarcinoma metastases associated with pulmonary, cutaneous, and diaphragmatic metastases.

Dimensions

Altmetric

PlumX Metrics

Downloads

Download data is not yet available.

Citations

Crossref
Scopus
Google Scholar
Europe PMC
Chen C, Zheng H, Jiang S. An Unusual Case of Giant Mediastinal Teratoma With Malignant Transformation. Ann Thorac Surg 2008;86:302-4. DOI: https://doi.org/10.1016/j.athoracsur.2007.07.087
Motzer RJ, Amsterdam A, Prieto V, et al. Teratoma with malignant transformation: diverse malignant histologies arising in men with germ cell tumors. J Urol 1998;159:133-8. DOI: https://doi.org/10.1016/S0022-5347(01)64035-7
Habougit C, Yvorel V, Sulaiman A, et al. Mediastinal mature teratoma with malignant carcinomatous transformation (somatic-type malignancy with metastatic course). Int J Surg Pathol 2015;23:682-4. DOI: https://doi.org/10.1177/1066896915591583
Chetaille B, Massard G, Falcoz P-E. Mediastinal germ cell tumors: anatomopathology, classification, teratomas and malignant tumors. Rev Pneumol Clin 2010;66:63-70. DOI: https://doi.org/10.1016/j.pneumo.2009.12.005
Shimizu K, Nakata M, Hirami Y, et al. Teratoma with malignant transformation in the anterior mediastinum. J Thorac Cardiovasc Surg 2008;136:225-7. DOI: https://doi.org/10.1016/j.jtcvs.2008.01.030
Honecker F, Stoop H, Mayer F, et al. Germ cell lineage differentiation in non seminomatous germ cell tumor. J Pathom 2006;208:395-400. DOI: https://doi.org/10.1002/path.1872
Curling OM, Potsides PN, Hundson CN. Malignant change in benign cystic teratoma of the ovary. Br J Obstet Gynecol 1979;86:399-402. DOI: https://doi.org/10.1111/j.1471-0528.1979.tb10619.x
Morinaga S, Nomori H, Kobayashi R, Atsumi Y. Well-differentiated adenocarcinoma arising from mature cystic teratoma of the mediastinum (teratoma with malignant transformation). Report of a surgical case. Am J Clin Pathol 1994;101:531-4. DOI: https://doi.org/10.1093/ajcp/101.4.531
Jung JI, Park SH, Park JG, et al. Teratoma with malignant transformation in the anterior mediastinum: a case report. Korean J Radiol 2000;1:162-4. DOI: https://doi.org/10.3348/kjr.2000.1.3.162
Popp G, Dragnev K. Secondary malignant transformation of a primary mediastinal germ cell tumor with diffuse lymphangitic spread to the lungs. South Med J 2003;96:696-8. DOI: https://doi.org/10.1097/01.SMJ.0000052064.60558.9A
Michel M, Pratt JW. Anterior mediastinal nonseminomatous germ cell tumor with malignant transformation: a case report. Curr Surg 2004;61:576-9. DOI: https://doi.org/10.1016/j.cursur.2004.05.021
Seki Y, Imaizumi M, Shigemitsu K, et al. Mucinous adenocarcinoma of the anterior mediastinum. Kyobu Geka 2004;57:413
Chang Y-L, Wu C-T, Lee Y-C. Mediastinal and retroperitoneal teratoma with focal gastrointestinal adenocarcinoma. J Thorac Oncol 2006;1:729-31. DOI: https://doi.org/10.1016/S1556-0864(15)30390-7
Duran I, Riveros L, Berthold DR, et al. Eyelid metastasis from mediastinal teratoma with malignant transformation. Acta Oncol 2007;46:1200-1. DOI: https://doi.org/10.1080/02841860701316073
El Mesbahi O, Terrier-Lacombe M-J, Rebischung C, et al. Chemotherapy in patients with teratoma with malignant transformation. Eur Urol 2007;51:1306-11. DOI: https://doi.org/10.1016/j.eururo.2006.10.021
Chen C, Zheng H, Jiang S. An unusual case of giant mediastinal teratoma with malignant transformation. Ann Thorac Surg 2008;86:302-4. DOI: https://doi.org/10.1016/j.athoracsur.2007.07.087
Saitou M, Niitsuma K. A case of teratoma with malignant transformation in the anterior mediastinum. Nihon Kokyuki - Gakkai Zasshi 2008;46:526-9.
Sakurai H, Miyashita Y, Oyama T. Adenocarcinoma arising in anterior mediastinal mature cystic teratoma: report of a case. Surg Today 2008;38:348-51. DOI: https://doi.org/10.1007/s00595-007-3633-2
Shimizu K, Nakata M, Hirami Y, et al. Teratoma with malignant transformation in the anterior mediastinum. J Thorac Cardiovasc Surg 2008;136:225-7. DOI: https://doi.org/10.1016/j.jtcvs.2008.01.030
Khurana A, Mehta A, Kamboj M. Colonic-type adenocarcinoma (somatic-type malignancy) arising in a mediastinal mature cystic teratoma: a case report of a rare entity. Indian J Pathol Microbiol 2011;54:199-200. DOI: https://doi.org/10.4103/0377-4929.77405
Muramatsu T, Nishii T, Ohmori K, Shiono M. Mature cystic teratoma with malignant transformation to adenocarcinoma. Ann Thorac Surg 2011;91:1971-3. DOI: https://doi.org/10.1016/j.athoracsur.2010.11.025
Kim J-Y, Lee C-H, Park W-Y, et al. Adenocarcinoma with sarcomatous dedifferentiation arising from mature cystic teratoma of the anterior mediastinum. Pathol Res Pract 2012;208:741-5. DOI: https://doi.org/10.1016/j.prp.2012.09.005
Dechaphunkul A, Bigras G, Sawyer M. Response to 5-fluorouracil-based chemotherapy in a patient with metastatic colonic-type adenocarcinoma arising in a primary mediastinalteratoma. Case Rep Oncol Med 2012;2012:729278. DOI: https://doi.org/10.1155/2012/729278
Paliwal N, Gupta K, Dewan RK, Mullick S. Adenocarcinoma (somatic-typemalignancy) in mature teratoma of anterior mediastinum. Indian J Chest Dis Allied Sci 2013;55:39-41. DOI: https://doi.org/10.5005/ijcdas-55-1-39
Abid H, Neji H, Haddar S, et al. Mediastinal mature teratoma with spontaneous malignant transformation. Rev Mal Respir 2013;30:424-8. DOI: https://doi.org/10.1016/j.rmr.2012.11.006
Habougit C, Yvorel V, Sulaiman A, et al. Mediastinal mature teratoma with malignant carcinomatous transformation (somatic-type malignancy) with metastatic course. Int J Surg Pathol 2015;23:682-4. DOI: https://doi.org/10.1177/1066896915591583
Lin C, Du Y, Li Y, et al. Superior mediastinal mature cystic teratoma with gastrointestinal adenocarcinoma transformation: Report of a case. Oncotarget 2016;7:38392-7. DOI: https://doi.org/10.18632/oncotarget.9532
Le Fèvre C, Vigneron C, Schuster H, et al. Metastatic mediastinal mature teratoma with malignant transformation in a young man with an adenocarcinoma in a Klinefelter's syndrome: Case report and review of the literature. Cancer Radiother 2018;22:255-63. DOI: https://doi.org/10.1016/j.canrad.2017.10.006
Murakami K, Hamaji M, Yoshizawa A, Date H. Sub-centimeter adenocarcinoma arising from mature mediastinal teratoma during 11 years of follow-up. Gen Thorac Cardiovasc Surg 2020;68:1543-6. DOI: https://doi.org/10.1007/s11748-020-01327-0
Athanasiou A, Vanel D, El Mesbahi O, et al. Non-germ cell tumors arising in germ cell tumors (teratoma with malignant transformation) in men: CT and MR findings. Eur J Radiol 2009;69:230-5. DOI: https://doi.org/10.1016/j.ejrad.2008.10.013
Wick MR, Ulbright TM, Moreira AL, et al. Germ cell tumors with somatic-type malignancy. In: Travis WD, Brambilla É, Müller-Hermelink HK, Harris CC, editors. World Health Organization classification of tumors. Pathology and genetics of tumours of the lung, pleura, thymus, and heart. Lyon, France: IARC Press; 2015.
Giannatempo P, Pond GR, Sonpavde G, et al. Treatment and clinical outcomes of patients with teratoma with somatic-type malignant transformation: an international collaboration. J Urol 2016;196:95-100. DOI: https://doi.org/10.1016/j.juro.2015.12.082
Chovanec M, Oravcova I, Demitrovicova L, et al. Malignant transformation of teratoma to adenocarcinoma with complete remission with all-trans retinoic acid-based treatment and surgery. Clin Genitourin Cancer 2016;14:e131-3. DOI: https://doi.org/10.1016/j.clgc.2015.10.001
Chang CC, Chang YL, Lee YC. Cystic malignant teratoma with early recurrence after intraoperative spillage. Ann Thorac Surg 2008;86:1971-3. DOI: https://doi.org/10.1016/j.athoracsur.2008.05.003
Comiter CV, Kibel AS, Richie JP, et al. Prognostic features of teratomas with malignant transformation: a clinicopathological study of 21 cases. J Urol 1998;159:859-63. DOI: https://doi.org/10.1016/S0022-5347(01)63754-6

How to Cite

Houcine, Y., Moussa, C., Abid, T., Hammami, S., Skhiri, H., & Ayadi, A. (2023). Metastatic intestinal adenocarcinoma arising within mature teratoma of the mediastinum: report of a surgically-resected case. Chest Disease Reports, 11(1). https://doi.org/10.4081/cdr.11.11840
Copyright (c) 2023 the Author(s) Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

PAGEPress has chosen to apply the Creative Commons Attribution NonCommercial 4.0 International License (CC BY-NC 4.0) to all manuscripts to be published.