https://doi.org/10.4081/ejtm.2021.9876

Lewy body dementia: Ursodeoxycholic acid as a putative treatment for gastrointestinal dysfunction

Vol. 31 No. 2 (2021)
Submitted: 25 May 2021
Accepted: 2 June 2021
Published: 11 June 2021
Gastrointestinal dysfunction, Lewy body dementia, ursodeoxycholic acid
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Authors

Mohsen Khosravi
dr_khosravi2016@yahoo.com
https://orcid.org/0000-0003-2970-6309
Department of Psychiatry and Clinical Psychology, Zahedan University of Medical Sciences, Zahedan, Iran, Islamic Republic of.

The autonomic nervous system (ANS) is a part of the peripheral nervous system that regulates internal organs function at an involuntary unconscious level. Recent evidence has shown that autonomic dysfunction is a common feature of Lewy body dementia (LBD). A wide range of autonomic symptoms may occur in LBD, which are correlated with poor prognosis. However, there is still no evidence-based approach to developing the best therapeutic strategy for autonomic dysfunction (particularly gastrointestinal symptoms) among LBD patients. This paper was intended to present a new perspective on ursodeoxycholic acid and its potential effects for treating gastrointestinal dysfunction in LBD patients.

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Scopus
Google Scholar
Europe PMC
Weintraub D, Bamford C, Allan LM, Thomas AJ, O'Brien JT. New evidence on the management of Lewy body dementia. Lancet Neurol. 2020 Feb;19(2):157-169. DOI: https://doi.org/10.1016/S1474-4422(19)30153-X
Allan LM. Diagnosis and Management of Autonomic Dysfunction in Dementia Syndromes. Curr Treat Options Neurol. 2019 Jul 10;21(8):38. DOI: https://doi.org/10.1007/s11940-019-0581-2
Rocha MS, Herbella FA, Del Grande JC, Ferreira AT, Tahan C, Patti MG. Effects of ursodeoxycholic acid in esophageal motility and the role of the mucosa. An experimental study. Dis Esophagus. 2011 May;24(4):291-4. DOI: https://doi.org/10.1111/j.1442-2050.2010.01137.x
Sirchak YS. Clinical efficacy of ursodeoxycholic acid in the comprehensive treatment of patients with obesity and gastroesophageal reflux disease. Gastroenterologia. 2018;52(4):207-15. DOI: https://doi.org/10.22141/2308-2097.52.4.2018.154140
Fang P, Dong L, Luo JY, Wan XL, Du KX, Chai NL. Effects of motilin and ursodeoxycholic acid on gastrointestinal myoelectric activity of different origins in fasted rats. World J Gastroenterol. 2004 Sep 1;10(17):2509-13. DOI: https://doi.org/10.3748/wjg.v10.i17.2509
Portincasa P, Peeters TL, van Berge-Henegouwen GP, van Solinge WW, Palasciano G, van Erpecum KJ. Acute intraduodenal bile salt depletion leads to strong gallbladder contraction, altered antroduodenal motility and high plasma motilin levels in humans. Neurogastroenterol Motil. 2000 Oct;12(5):421-30. DOI: https://doi.org/10.1046/j.1365-2982.2000.00217.x
Luiking YC, Peeters TL, Stolk MF, Nieuwenhuijs VB, Portincasa P, Depoortere I, van Berge Henegouwen GP, Akkermans LM. Motilin induces gall bladder emptying and antral contractions in the fasted state in humans. Gut. 1998 Jun;42(6):830-5. DOI: https://doi.org/10.1136/gut.42.6.830
Colecchia A, Mazzella G, Sandri L, Azzaroli F, Magliuolo M, Simoni P, Bacchi-Reggiani ML, Roda E, Festi D. Ursodeoxycholic acid improves gastrointestinal motility defects in gallstone patients. World J Gastroenterol. 2006 Sep 7;12(33):5336-43. DOI: https://doi.org/10.3748/wjg.v12.i33.5336
Nirwan JS, Hasan SS, Babar ZU, Conway BR, Ghori MU. Global Prevalence and Risk Factors of Gastro-oesophageal Reflux Disease (GORD): Systematic Review with Meta-analysis. Sci Rep. 2020 Apr 2;10(1):5814. DOI: https://doi.org/10.1038/s41598-020-62795-1
Ticho AL, Malhotra P, Dudeja PK, Gill RK, Alrefai WA. Bile Acid Receptors and Gastrointestinal Functions. Liver Res. 2019 Mar;3(1):31-39. DOI: https://doi.org/10.1016/j.livres.2019.01.001

How to Cite

Khosravi, M. (2021). Lewy body dementia: Ursodeoxycholic acid as a putative treatment for gastrointestinal dysfunction. European Journal of Translational Myology, 31(2). https://doi.org/10.4081/ejtm.2021.9876

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