https://doi.org/10.4081/ejtm.2021.9817

Isolated hyperbilirubinemia as the manifestation of acute liver failure in a patient with acute myelogenous leukemia and COVID-19 infection

Vol. 31 No. 3 (2021)
Submitted: 18 April 2021
Accepted: 22 May 2021
Published: 1 July 2021
Isolated hyperbilirubinemia, acute myelogenous leukemia, acute liver failure, COVID-19
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Authors

Nasrin Gholami
dr.gholami_internist@yahoo.com
Hematology Oncology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran, Islamic Republic of.
Vahid Sheykhzadeh Amzajerdi
Hematology Oncology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran, Islamic Republic of.
Rahim Mehdioghli
Hematology Oncology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran, Islamic Republic of.
Hengameh Khadivi Heris
Hematology Oncology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran, Islamic Republic of.
Mona Jahandideh Kazempour
Deparment of Microbiology, Faculty of Medical Genetic, Science and Research Islamic Azad University, Tehran, Iran, Islamic Republic of.

Acute liver failure is a rare but catastrophic syndrome. Liver function tests usually reveal cholestatic or hepatocellular pattern, but in this case, we report a previously undescribed manifestation of this condition as isolated hyperbilirubinemia. Our patient was a 50 years old male who was diagnosed with acute myelogenous leukemia (AML(M4)). The patient had no history of liver disease and had normal liver function tests at the time of admission. After chemotherapy treatment, the patient developed signs of acute liver failure and had a rapid demise. After further investigations, we found two possible causes. Firstly, liver involvement of acute myelogenous leukemia (AML) which after induction chemotherapy is a rare condition and has high mortality rates despite treatment. Secondly, acute liver injury due to COVID-19 infection.

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How to Cite

Gholami, N., Amzajerdi, V. S., Mehdioghli, R., Heris, H. K., & Kazempour, M. J. (2021). Isolated hyperbilirubinemia as the manifestation of acute liver failure in a patient with acute myelogenous leukemia and COVID-19 infection. European Journal of Translational Myology, 31(3). https://doi.org/10.4081/ejtm.2021.9817

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