https://doi.org/10.4081/ejtm.2020.9306
Farewell to Professor David Yaffe – A Pillar of the Myogenesis Field
Published: 18 August 2020
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All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Authors
It is with great sadness that we have learned about the passing of Professor David Yaffe (1929-2020, Israel). Yehi Zichro Baruch - May his memory be a blessing. David was a man of family, science and nature. A native of Israel, David grew up in the historic years that preceded the birth of the State of Israel. He was a member of the group that established Kibbutz Revivim in the Negev desert, and in 1948 participated in Israel’s War of Independence. David and Ruth eventually joined Kibbutz Givat Brenner by Rehovot, permitting David to be both a kibbutz member and a life-long researcher at the Weizmann Institute of Science, where David received his PhD in 1959. David returned to the Institute after his postdoc at Stanford. Here, after several years of researching a number of tissues as models for studying the process of differentiation, David entered the myogenesis field and stayed with it to his last day. With his dedication to the field of myogenesis and his commitment to furthering the understanding of the People and the Land of Israel throughout the international scientific community, David organized the first ever myogenesis meeting that took place in Shoresh, Israel in 1975. This was followed by the 1980 myogenesis meeting at the same place and many more outstanding meetings, all of which brought together myogenesis, nature and scenery. Herein, through the preparation and publication of this current manuscript, we are meeting once again at a “David Yaffe myogenesis meeting". Some of us have been members of the Yaffe lab, some of us have known David as his national and international colleagues in the myology field. One of our contributors has also known (and communicates here) about David Yaffe’s earlier years as a kibbutznick in the Negev. Our collective reflections are a tribute to Professor David Yaffe. We are fortunate that the European Journal of Translational Myology has provided us with tremendous input and a platform for holding this 2020 distance meeting "Farwell to Professor David Yaffe - A Pillar of the Myogenesis Field".
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Vilquin JT, Guérette B, Puymirat J, Yaffe D, Tomé FM, Fardeau M, Fiszman M, Schwartz K, Tremblay JP. Myoblast transplantations lead to the expression of the laminin alpha 2 chain in normal and dystrophic (dy/dy) mouse muscles. Gene Ther 1999;6:792-800. doi: 10.1038/sj.gt.3300889
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Sarig R, Baruchi Z, Fuchs O, Nudel U, Yaffe D. Regeneration and transdifferentiation potential of muscle-derived stem cells propagated as myospheres. Stem Cells 2006;24:1769-78. doi: 10.1634/stemcells.2005-0547
DOI: https://doi.org/10.1634/stemcells.2005-0547
Shcherbata HR, Yatsenko AS, Patterson L, Sood VD, Nudel U, Yaffe D, Baker D, Ruohola-Baker H. Dissecting muscle and neuronal disorders in a Drosophila model of muscular dystrophy. EMBO J. 2007;26:481-93. doi: 10.1038/sj.emboj.7601503.
DOI: https://doi.org/10.1038/sj.emboj.7601503
Taghli-Lamallem O, Akasaka T, Hogg G, Nudel U, Yaffe D, Chamberlain JS, Ocorr K, Bodmer R. Dystrophin deficiency in Drosophila reduces lifespan and causes a dilated cardiomyopathy phenotype. Aging Cell 2008;7:237-49. doi: 10.1111/j.1474-9726.2008.00367.x.
DOI: https://doi.org/10.1111/j.1474-9726.2008.00367.x
Fort PE, Sene A, Pannicke T, Roux MJ, Forster V, Mornet D, Nudel U, Yaffe D, Reichenbach A, Sahel JA, Rendon A. Kir4.1 and AQP4 associate with Dp71- and utrophin-DAPs complexes in specific and defined microdomains of Müller retinal glial cell membrane. Glia 2008 Apr 15;56(6):597-610. doi: 10.1002/glia.20633
DOI: https://doi.org/10.1002/glia.20633
Daoud F, Candelario-Martínez A, Billard JM, Avital A, Khelfaoui M, Rozenvald Y, Guegan M, Mornet D, Jaillard D, Nudel U, Chelly J, Martínez-Rojas D, Laroche S, Yaffe D, Vaillend C. Role of mental retardation-associated dystrophin-gene product Dp71 in excitatory synapse organization, synaptic plasticity and behavioral functions. PLoS One 2008;4:e6574. doi: 10.1371/journal.pone.0006574
DOI: https://doi.org/10.1371/journal.pone.0006574
Aharoni R, Aizman E, Fuchs O, Arnon R, Yaffe D, Sarig R. Transplanted myogenic progenitor cells express neuronal markers in the CNS and ameliorate disease in experimental autoimmune encephalomyelitis. J Neuroimmunol 2009;215:73-83. doi: 10.1016/j.jneuroim.2009.08.009.
DOI: https://doi.org/10.1016/j.jneuroim.2009.08.009
Sarig R, Fuchs O, Tencer L, Panski A, Nudel U, Yaffe D. Cloned myogenic cells can transdifferentiate in vivo into neuron-like cells. PLoS One. 2010;5:e8814. doi: 10.1371/journal.pone.0008814.
DOI: https://doi.org/10.1371/journal.pone.0008814
Benabdesselam R, Sene A, Raison D, Benmessaoud-Mesbah O, Ayad G, Mornet D, Yaffe D, Rendon A, Hardin-Pouzet H, Dorbani-Mamine L. A deficit of brain dystrophin 71 impairs hypothalamic osmostat. J Neurosci Res 2010;88:324-34. doi: 10.1002/jnr.22198.
DOI: https://doi.org/10.1002/jnr.22198
Dadon-Nachum M, Ben-Zur T, Srugo I, Shamir HM, Melamed E, Yaffe D, Offen D. Therapeutic effect of myogenic cells modified to express neurotrophic factors in a rat model of sciatic nerve injury. J Stem Cells Regen Med 2012;8:21-7. doi: 10.46582/jsrm.0801004.
DOI: https://doi.org/10.46582/jsrm.0801004
Dadon-Nachum M, Ben-Yaacov K, Ben-Zur T, Barhum Y, Yaffe D, Perlson E, Offen D. Transplanted modified muscle progenitor cells expressing a mixture of neurotrophic factors delay disease onset and enhance survival in the SOD1 mouse model of ALS. J Mol Neurosci 2015;55:788-97. doi: 10.1007/s12031-014-0426-0.
DOI: https://doi.org/10.1007/s12031-014-0426-0
Glat MJ, Benninger F, Barhum Y, Ben-Zur T, Kogan E, Steiner I, Yaffe D, Offen D. Ectopic Muscle Expression of Neurotrophic Factors Improves Recovery After Nerve Injury. J Mol Neurosci 2016;58:39-45. doi: 10.1007/s12031-015-0648-9.
DOI: https://doi.org/10.1007/s12031-015-0648-9
Guy R, Grynspan F, Ben-Zur T, Panski A, Lamdan R, Danon U, Yaffe D, Offen D. Human muscle progenitor cells overexpressing neurotrophic factors improve neuronal regeneration in a sciatic nerve injury mouse model. Front Neurosci 2019;13:151. doi: 10.3389/fnins.2019.00151.
DOI: https://doi.org/10.3389/fnins.2019.00151
Kern H, Boncompagni S, Rossini K, Mayr W, Fanò G, Zanin ME, Podhorska-Okolow M, Protasi F, Carraro U. Long-term denervation in humans causes degeneration of both contractile and excitation-contraction coupling apparatus, which is reversible by functional electrical stimulation (FES): a role for myofiber regeneration? J Neuropathol Exp Neurol. 2004;63:919-31. doi: 10.1093/jnen/63.9.919.
DOI: https://doi.org/10.1093/jnen/63.9.919
Carraro U, Kern H. Severely atrophic human muscle fibers with nuclear misplacement survive many years of permanent denervation. Eur J Transl Myol 2016;26(2):5894. doi: 10.4081/ejtm.2016.5894
DOI: https://doi.org/10.4081/ejtm.2016.5894
Kern H. Carraro U. Home-based functional electrical stimulation of human permanent denervated muscles: A narrative review on diagnostics, managements, results and byproducts Revisited 2020. Diagnostics 2020;10, 529. doi: 10.3390/diagnostics10080529
DOI: https://doi.org/10.3390/diagnostics10080529
Some of the biographical information in this paragraph and the images in Figs 1 and 3 are from a PDF found online “The Graduates”, published by the Weizmann Institute of Science, celebrating 50 years of excellent of its Feinberg Graduate School (published ~2008). https://wis-wander.Weizmann.ac.il/sites/default/files/images/Books/The%20Graduates.pdf Additional biographical details were contributed by Dr. Gania Kessler-Icekson.
EMBO workshop on muscle cell culture in the study of gene expression during differentiation, Shoresh, Israel 1975.
EMBO Workshop on Myogenesis and Molecular Genesis of Muscle Diseases. Ein-Gedi, Israel, 1996.
How to Cite
Yablonka-Reuveni, Z., Stockdale, F., Nudel, U., Israeli, D., Blau, H. M., Shainberg, A., Neuman, S., Kessler-Icekson, G., Meghid Krull, E., Paterson, B., Saxel Fuchs, O., Greenberg, D., Sarig, R., Halevy, O., Ozawa, E., & Katcoff, D. J. (2020). Farewell to Professor David Yaffe – A Pillar of the Myogenesis Field. European Journal of Translational Myology, 30(3). https://doi.org/10.4081/ejtm.2020.9306
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