https://doi.org/10.4081/ejtm.2019.8903

Using high density EEG to assess TMS treatment in patients with schizophrenia

Vol. 30 No. 1 (2020)
Submitted: 15 February 2020
Accepted: 4 March 2020
Published: 1 April 2020
Transcranial magnetic stimulation, schizophrenia, high density EEG, P50, P300
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Authors

Sara Marcu
Reykjavik University, School of Science and Engineering, Biomedical Engineering, Reykjavik, Iceland; Department of Information Engineering, University of Padova, Italy.
Elena Pegolo
Reykjavik University, School of Science and Engineering, Biomedical Engineering, Reykjavik, Iceland; Department of Information Engineering, University of Padova, Italy.
Eysteinn Ívarsson
Clinical Neurophysiology Unit, Neurology Department, National University Hospital of Iceland, Iceland.
Aron D. Jónasson
Clinical Neurophysiology Unit, Neurology Department, National University Hospital of Iceland, Iceland.
Viktor D. Jónasson
Psychiatric Department, National University Hospital of Iceland, Iceland.
Romain Aubonnet
Reykjavik University, School of Science and Engineering, Biomedical Engineering, Reykjavik, Iceland.
Paolo Gargiulo
Reykjavik University, School of Science and Engineering, Biomedical Engineering, Reykjavik, Iceland.
Ovidiu Constantin Banea
ovidiubanea@gmail.com
Reykjavik University, School of Science and Engineering, Biomedical Engineering, Reykjavik; Clinical Neurophysiology Unit, Neurology Department, National University Hospital of Iceland, Iceland.

We present preliminary results from the ongoing study entitled “Icelandic AVH-TMS” which aim is to study the effectiveness of repetitive transcranial magnetic stimulation (rTMS) treatment for patients with schizophrenia and with persistent auditory verbal hallucinations (AVH) using symptoms and psychometric scales and high-density EEG system (256 channels). The aim of the present work was to describe cortical topography of the auditory evoked responses like P50 and N100-P300 complex in healthy participants and patients with schizophrenia and to define a robust methodology of signal quantification using dense-array EEG. Preliminary data is shown for three healthy participants and three patients in baseline conditions and for two patients we show the results recorded before and after 10 days rTMS treatment. Our results show differences in sensory gating (P50 suppresion) and a stronger N100-P300 response to rare audio stimulus after the treatment. Moreover we show the value of assessing brain electrical activity from high-density EEG (256 channels) analyzing the results in different regions of interest. However, it is premature and hazardous to assume that rTMS treatment effectiveness in patients with AVH can be assessed using P50 suppression ratio.

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How to Cite

Marcu, S., Pegolo, E., Ívarsson, E., Jónasson, A. D., Jónasson, V. D., Aubonnet, R., Gargiulo, P., & Banea, O. C. (2020). Using high density EEG to assess TMS treatment in patients with schizophrenia. European Journal of Translational Myology, 30(1), 134–138. https://doi.org/10.4081/ejtm.2019.8903

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