Exercise preserves muscle mass and force in a prostate cancer mouse model

Submitted: 28 August 2019
Accepted: 27 September 2019
Published: 12 November 2019
Abstract Views: 1964
PDF: 842
HTML: 22
Publisher's note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.

Authors

The purpose of this study was to examine the effects of exercise in modulating biomarkers of sarcopenia in a treatment naïve transgenic adenocardinoma of the mouse prostate (TRAMP) model. Thirty TRAMP mice were randomized to either exercise (voluntary wheel running) or no-treatment control group for a period of 20 weeks. During necropsy, gastrocnemius muscles and prostate tumors were harvested and weighed. Gastrocnemius concentrations of myostatin, insulin-like growth factor (IGF)-1 and tumor necrosis factor (TNF)-α were quantified. Exercise mice had greater muscle mass than controls (p=0.04). Myostatin was significantly lower in the exercise group compared to controls (p=0.01). Exercise mice maintained forelimb grip force while control mice had a significaint decrease (p=0.01). No significant difference was observed in pre-post all limb grip strength. Further, forelimb and all limb grip strength was negatively associated with tumor mass (p<0.01).

Dimensions

Altmetric

PlumX Metrics

Downloads

Download data is not yet available.

Citations

How to Cite

Patel, D. I., Abuchowski, K., Sheikh, B., Rivas, P., Musi, N., & Kumar, A. P. (2019). Exercise preserves muscle mass and force in a prostate cancer mouse model. European Journal of Translational Myology, 29(4). https://doi.org/10.4081/ejtm.2019.8520

Similar Articles

1 2 > >> 

You may also start an advanced similarity search for this article.