https://doi.org/10.4081/ejtm.2024.12993

Vitamin D receptor gene polymorphisms in patients with relapsing multiple sclerosis

Early Access
Submitted: 30 August 2024
Accepted: 16 September 2024
Published: 21 November 2024
Relapsing multiple sclerosis, vitamin D, gene polymorphisms
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Authors

Maryam Milanifard
Department of Anatomy, School of Medicine, Iran University of Medical Sciences, Tehran, Iran, Islamic Republic of.
Soraya Mehrabi
Department of Neuroscience, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran, Islamic Republic of.
Reza Ahadi
Department of Anatomical Sciences, School of Medicine, Iran University of Medical Sciences, Tehran, Iran, Islamic Republic of.
Mohsen Nabiuni
https://orcid.org/0000-0002-0841-6612
Department of Neurosurgery, Iran University of Medical Sciences, Tehran, Iran, Islamic Republic of.
Samaneh Azimi Souteh
Department of Neuroscience, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran; Department of Anatomical Sciences, School of Medicine, Iran University of Medical Sciences, Tehran, Iran; Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran, Islamic Republic of.
Mohammad Taghi Joghataei
m_joghataei@yahoo.com
Department of Neuroscience, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran, Iran, Islamic Republic of.

The relationship between the vitamin D receptor (VDR) gene and many pathogenic pathways in relapsing-remitting multiple sclerosis (RRMS) remains unclear. Given the significance of the topic, we conducted this study to explore the correlation between vitamin D receptor gene polymorphisms and clinical and inflammatory factors in patients suffering from relapsing-remitting multiple sclerosis. The current research is a case/control study conducted based on the Helsinki Ethical Principles. RRMS disease was confirmed based on history, clinical symptoms, radiological signs and neurologist diagnosis. The research population consisted of healthy people and patients with RRMS who were referred to Hazrat Rasool Akram Hospital between 2021 and 2023. For each person participating in the study (RRMS patient and healthy), five milliliters of peripheral blood containing the anticoagulant EDTA was collected. Polymerase chain reaction was performed using two specific and appropriate oligonucleotide primers. The restriction fragment length polymorphism technique was used, one of the standard methods for identifying polymorphisms. Statistical analysis was performed using SPSS software version 23. The odds ratio and 95% confidence limits were calculated. The SNP Analyzer software was used to analyze the allele frequency of each polymorphism in healthy and RRMS individuals and compare the values. Prism version 5 software was used to draw diagrams. In the present study, a statistically significant difference was observed between the percentage of FokI genotypes in RRMS patients and healthy individuals. FokI polymorphism showed a significantly increased risk with an odds ratio of 7.28 in patients with the FF genotype compared to healthy individuals. ApaI, TaqI, and BsmI were not significantly different between the two groups. Based on the findings of the present study, FokI polymorphism showed a significant risk increase in RRMS patients with FF genotype compared to healthy individuals.

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How to Cite

Milanifard, M., Mehrabi, S., Ahadi, R., Nabiuni, M., Azimi Souteh, S., & Joghataei, M. T. (2024). Vitamin D receptor gene polymorphisms in patients with relapsing multiple sclerosis. European Journal of Translational Myology. https://doi.org/10.4081/ejtm.2024.12993
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