https://doi.org/10.4081/ejtm.2024.12693
The time course of irisin release after an acute exercise: relevant implications for health and future experimental designs
Submitted: 30 May 2024
Accepted: 20 June 2024
Published: 1 July 2024
Accepted: 20 June 2024
Abstract Views: 300
PDF: 200
HTML: 6
HTML: 6
Publisher's note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Authors
This study aimed to analyze the acute impact of exercise on serum irisin levels in 22 young (YA, 24.6 ± 3.5 yrs) and in 12 middle-aged male adults (MA, 54.6 ± 5.7 yrs) 15 min and 24 h after an incremental cycling exercise test to exhaustion. ELISA assay was used for serum irisin detection. Circulating irisin increased significantly from baseline (9.0 ± 2.0 ng/ml) to 15 min post-exercise (10.2 ± 2.0 ng/ml, P < 0.001), but the greatest increment was detected after 24 h (13.5 ± 2.5 ng/ml, P < 0.001) reaching more than 50% of the basal release. Levels were significantly higher in YA (9.7 ± 1.7 to 11.1 ± 1.8 to 14.5 ± 2.2 ng/ml) than MA (7.6 ± 1.6 to 8.7 ± 1.5 to 11.8± 2.2 ng/ml) for all measured time-points (P < 0.05). Nevertheless, MA showed a comparable increase in serum irisin levels when compared to YA. These findings highlight the importance of acute physical exercise as a countermeasure against age-related deterioration of skeletal muscle mass and function in both YA and MA.
Boström P, Wu J, Jedrychowski MP, et al. A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis. Nature 2012;481:463-8.
DOI: https://doi.org/10.1038/nature10777
Trettel CDS, Pelozin BRA, Barros MP, et al. Irisin: An anti-inflammatory exerkine in aging and redox-mediated comorbidities. Front Endocrinol (Lausanne) 2023;14:1106529.
DOI: https://doi.org/10.3389/fendo.2023.1106529
Kornel A, Den Hartogh DJ, Klentrou P, Tsiani E. Role of the Myokine Irisin on Bone Homeostasis: Review of the Current Evidence. Int J Mol Sci 2021;22:9136.
DOI: https://doi.org/10.3390/ijms22179136
Canivet CM, Bonnafous S, Rousseau D, et al. Hepatic FNDC5 is a potential local protective factor against Non-Alcoholic Fatty Liver. Biochim Biophys Acta Mol Basis Dis 2020;1866:165705.
DOI: https://doi.org/10.1016/j.bbadis.2020.165705
Huh JY, Dincer F, Mesfum E, Mantzoros CS. Irisin stimulates muscle growth-related genes and regulates adipocyte differentiation and metabolism in humans. Int J Obes (Lond) 2014;38:1538-44.
DOI: https://doi.org/10.1038/ijo.2014.42
Yano N, Zhao YT, Zhao TC. The Physiological Role of Irisin in the Regulation of Muscle Glucose Homeostasis. Endocrines. 2021;2:266-83.
DOI: https://doi.org/10.3390/endocrines2030025
Fox J, Rioux BV, Goulet EDB, et al. Effect of an acute exercise bout on immediate post-exercise irisin concentration in adults: A meta-analysis. Scand J Med Sci Sports 2018;28:16-28.
DOI: https://doi.org/10.1111/sms.12904
Kazeminasab F, Sadeghi E, Afshari-Safavi A. Comparative Impact of Various Exercises on Circulating Irisin in Healthy Subjects: A Systematic Review and Network Meta-Analysis. Oxid Med Cell Longe 2022;2022:8235809.
DOI: https://doi.org/10.1155/2022/8235809
Daskalopoulou SS, Cooke AB, Gomez YH, et al. Plasma irisin levels progressively increase in response to increasing exercise workloads in young, healthy, active subjects. Eur J Endocrinol 2014;171:343-52.
DOI: https://doi.org/10.1530/EJE-14-0204
Tsuchiya Y, Ando D, Goto K, et al. High-intensity exercise causes greater irisin response compared with low-intensity exercise under similar energy consumption. Tohoku J Exp Med 2014;233:135-40.
DOI: https://doi.org/10.1620/tjem.233.135
Löffler D, Müller U, Scheuermann K, et al. Serum irisin levels are regulated by acute strenuous exercise. J Clin Endocrinol Metab 2015;100:1289-99.
DOI: https://doi.org/10.1210/jc.2014-2932
Zügel M, Qiu S, Laszlo R, et al. The role of sex, adiposity, and gonadectomy in the regulation of irisin secretion. Endocrine 2016;54:101-10.
DOI: https://doi.org/10.1007/s12020-016-0913-x
Qiu S, Bosnyák E, Treff G, et al. Acute exercise-induced irisin release in healthy adults: Associations with training status and exercise mode. Eur J Sport Sci 2018;18:1226-33.
DOI: https://doi.org/10.1080/17461391.2018.1478452
Rodziewicz E, Król-Zielińska M, Zieliński J, et al. Plasma concentration of irisin and brain-derived-neurotrophic factor and their association with the level of erythrocyte adenine nucleotides in response to long-term endurance training at rest and after a single bout of exercise. Front Physiol 2020;11:923.
DOI: https://doi.org/10.3389/fphys.2020.00923
Huh JY, Panagiotou G, Mougios V, et al. FNDC5 and irisin in humans: I. Predictors of circulating concentrations in serum and plasma and II. mRNA expression and circulating concentrations in response to weight loss and exercise. Metabolism 2012;61:1725-38.
DOI: https://doi.org/10.1016/j.metabol.2012.09.002
Clark BC, Manini TM. Functional consequences of sarcopenia and dynapenia in the elderly. Curr Opin Clin Nutr Metab Care 2010;13:271-6.
DOI: https://doi.org/10.1097/MCO.0b013e328337819e
Ruan Q, Huang Y, Yang L, et al. The effects of both age and sex on irisin levels in paired plasma and cerebrospinal fluid in healthy humans. Peptides 2019;113:41-51.
DOI: https://doi.org/10.1016/j.peptides.2019.01.004
Huh JY, Mougios V, Kabasakalis A, et al. Exercise-induced irisin secretion is independent of age or fitness level and increased irisin may directly modulate muscle metabolism through AMPK activation. J Clin Endocrinol Metab 2014;99:E2154-61.
DOI: https://doi.org/10.1210/jc.2014-1437
Gmiat A, Micielska K, Kozłowska M, et al. The impact of a single bout of high intensity circuit training on myokines' concentrations and cognitive functions in women of different age. Physiol Behav 2017;179:290-7.
DOI: https://doi.org/10.1016/j.physbeh.2017.07.004
Rioux BV, Brunt KR, Eadie AL, et al. Impact of acute circuit training on irisin in younger and older overweight adults. Appl Physiol Nutr Metab 2021;46:1248-56.
DOI: https://doi.org/10.1139/apnm-2020-1087
McCormick JJ, King KE, Notley SR, et al. Exercise in the heat induces similar elevations in serum irisin in young and older men despite lower resting irisin concentrations in older adults. J Therm Biol 2022;104:103189.
DOI: https://doi.org/10.1016/j.jtherbio.2022.103189
Lachman ME. Development in midlife. Annu Rev Psychol 2004;55:305-31.
DOI: https://doi.org/10.1146/annurev.psych.55.090902.141521
Wagner DR, Gibson AL. Health-Related Physical Fitness Testing and Interpretation. In: ACSM’s guidelines for exercise testing and prescription. Ed: Liguori, G. 11th ed. Wolters Kluwer, Philadelphia; 2021. pp 116-182.
Mannocci A, Di Thiene D, Del Cimmuto A, et al. International Physical Activity Questionnaire: validation and assessment in an Italian sample. Inter J Public Health 2010;7:369-76.
DOI: https://doi.org/10.2427/5694
Jürimäe J, Purge P, Tillmann V. Serum sclerostin and cytokine responses to prolonged sculling exercise in highly-trained male rowers. J Sports Sci 2021;39:591-7.
DOI: https://doi.org/10.1080/02640414.2020.1837428
Forde C. Scoring the international physical activity questionnaire (IPAQ) exercise prescription for the prevention and treatment of disease. Exercise Prescription for the Prevention and Treatment of Disease. Trinity College Dublin, University of Dublin. 2005.
Norheim F, Langleite TM, Hjorth M, et al. The effects of acute and chronic exercise on PGC-1α, irisin and browning of subcutaneous adipose tissue in humans. FEBS J 2014;281:739-49.
DOI: https://doi.org/10.1111/febs.12619
Missaglia S, Tommasini E, Vago P, et al. Salivary and serum irisin in healthy adults before and after exercise. Eur J Transl Myol 2023;33:11093.
DOI: https://doi.org/10.4081/ejtm.2023.11093
Scalzo RL, Peltonen GL, Giordano GR, et al. Regulators of human white adipose browning: evidence for sympathetic control and sexual dimorphic responses to sprint interval training. PLoS One 2014;9:e90696.
DOI: https://doi.org/10.1371/journal.pone.0090696
Wiecek M, Szymura J, Maciejczyk M, et al. Acute anaerobic exercise affects the secretion of asprosin, irisin, and other cytokines - a comparison between sexes. Front Physiol 2018;9:1782.
DOI: https://doi.org/10.3389/fphys.2018.01782
How to Cite
Tommasini, E., Missaglia, S., Vago, P., Galvani, C., Pecci, C., Rampinini, E., Bosio, A., Morelli, A., Bonanomi, A., Silvestrini, A., Mordente, A., & Tavian, D. (2024). The time course of irisin release after an acute exercise: relevant implications for health and future experimental designs . European Journal of Translational Myology, 34(2). https://doi.org/10.4081/ejtm.2024.12693
Copyright (c) 2024 the Author(s)
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
PAGEPress has chosen to apply the Creative Commons Attribution NonCommercial 4.0 International License (CC BY-NC 4.0) to all manuscripts to be published.
Similar Articles
- Francesca Riuzzi, Emanuele Mocciaro, Report and Abstracts of the 20th Meeting of IIM, the Interuniversity Institute of Myology: Assisi, October 12-15, 2023 , European Journal of Translational Myology: Vol. 34 No. 2 (2024)
You may also start an advanced similarity search for this article.