https://doi.org/10.4081/ejtm.2022.10671
Predicting value of HE4 and CA125 markers for optimal cytoreductive surgery in ovarian cancer patients
Submitted: 13 June 2022
Accepted: 26 June 2022
Published: 1 August 2022
Accepted: 26 June 2022
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All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Authors
We conducted a cross-sectional study to evaluate the role of serum levels of CA125 and HE4 in predicting optimal cytoreductive surgery. Eligible women who had been diagnosed with ovarian cancer based on both clinical and imaging criteria were enrolled in this study. Serum levels of CA 125 and HE4 were checked before surgery and all patients underwent complete surgical staging. After completion of the pathological evaluation, data were entered in SPSS version 23. One hundred and ten individuals were enrolled in our study. We divided cases between two groups: stage I to III b and stage IIIc to IV. Serum level of HE4 >170 pmol/L can predict optimal cytoreductive surgery before operation. (sensitivity:80% and specificity 70%) and serum level of CA 125 > 320 UI/mL can predict optimal cytoreductive surgery before operation. (sensitivity:80% and specificity 70%). Our data demonstrated a negative predictive value of about 80% for both HE4 and CA125. Based on these cut-off, unnecessary surgery can be avoided in many cases, however, it is unwise to ignore clinical performance and radiological findings. Nevertheless, we can say the evaluation of tumor markers is feasible and helpful in predicting optimal surgery.
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How to Cite
Saffarieh, E., Nassiri, S., & Mirmohammadkhani, M. (2022). Predicting value of HE4 and CA125 markers for optimal cytoreductive surgery in ovarian cancer patients. European Journal of Translational Myology, 32(3). https://doi.org/10.4081/ejtm.2022.10671
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