https://doi.org/10.4081/ejtm.2022.10670
Evaluation of the diagnostic accuracy of the cervical biopsy under colposcopic vision
Submitted: 13 June 2022
Accepted: 22 June 2022
Published: 12 October 2022
Accepted: 22 June 2022
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All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
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This study was conducted to evaluate the diagnostic accuracy of the cervical biopsy under colposcopic vision. This retrospective study was performed on 190 women, who were selected from a total of 412 cases referring for colposcopy in one year. All patients underwent colposcopy and loop electrosurgical excision procedure (LEEP). After the investigation of demographic characteristics and data confirmation, colposcopic characteristics were examined. Then, the diagnostic indicators and diagnostic accuracy of the cervical biopsy under colposcopic vision were determined. The mean age of patients was 35.51± 5.91 years. In smokers, the percentage of cancer and CIN3 cases was higher than in normal individuals, and this difference was statistically significant in terms of the frequency of cancerous lesions (P = 0.2). A comparison of colposcopic biopsy with LEEP has shown that the frequency of advanced cases in LEEP has been detected more, and the correlation coefficient (kappa) indicated the weak agreement between the findings of colposcopically directed biopsy (CDB) and LEEP methods. (k = 0.23). The diagnostic accuracy of the cervical biopsy under colposcopic vision for cervical cancer is effectively high. It is recommended that this procedure be performed to diagnose cancerous lesions; however, contrary to what is seen in colposcopy, malignant cases may be spreading and follow-up of patients can affect therapeutic performance.
Arbyn M, Weiderpass E, Bruni L, de Sanjosé S, Saraiya M, Ferlay J, Bray F. Estimates of incidence and mortality of cervical cancer in 2018: a worldwide analysis. Lancet Glob Health. 2020 Feb;8(2):e191-e203. Epub 2019 Dec 4. Erratum in: Lancet Glob Health. 2022 Jan;10(1):e41.
DOI: https://doi.org/10.1016/S2214-109X(19)30482-6
Khodakarami N, Hosseini S, Yavari P, Farzaneh F, Etemad K, Salehpour S. Human Papillomavirus Infection Prevalence in Women Referred to Health Clinic of Shahid Beheshti University of Medical Sciences, Tehran, Iran. irje. 2012; 7 (4) :35-42. URL: http://irje.tums.ac.ir/article-1-29-en.html
Ndifon CO, Al-Eyd G. Atypical Squamous Cells of Undetermined Significance. 2020 Dec 26. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; Last Update: April 28, 2022. https://www.ncbi.nlm.nih.gov/books/NBK557739/
Massad LS, Einstein MH, Huh WK, Katki HA, Kinney WK, Schiffman M, Solomon D, Wentzensen N, Lawson HW; 2012 ASCCP Consensus Guidelines Conference. 2012 updated consensus guidelines for the management of abnormal cervical cancer screening tests and cancer precursors. J Low Genit Tract Dis. 2013 Apr;17(5 Suppl 1):S1-S27. Erratum in: J Low Genit Tract Dis. 2013 Jul;17(3):367.
DOI: https://doi.org/10.1097/LGT.0b013e318287d329
Mello V, Sundstrom RK. Cervical Intraepithelial Neoplasia. 2020 Aug 12. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2021 Jan. PMID: 31335091.
Berek JS. Novak's Gynecology. Lippincott Williams & Wilkins; 13th edition 2002. p. 471.
Burger MP, Hollema H. The reliability of the histologic diagnosis in colposcopically directed biopsies. A plea for LETZ. Int J Gynecol Cancer. 1993 Nov;3(6):385-390.
DOI: https://doi.org/10.1046/j.1525-1438.1993.03060385.x
Li M, Zhao Y, Qie M, Zhang Y, Li L, Lin B, Guo R, You Z, An R, Liu J, Zhang Z, Bi H, Hong Y, Chang S, He G, Hua K, Zhou Q, Liao Q, Wang Y, Wang J, Li X, Wei L. Management of Cervical Cancer in Pregnant Women: A Multi-Center Retrospective Study in China. Front Med (Lausanne). 2020 Dec 7;7:538815.
DOI: https://doi.org/10.3389/fmed.2020.538815
Müller K, Soergel P, Hillemanns P, Jentschke M. Accuracy of Colposcopically Guided Diagnostic Methods for the Detection of Cervical Intraepithelial Neoplasia. Geburtshilfe Frauenheilkd. 2016 Feb;76(2):182-187.
DOI: https://doi.org/10.1055/s-0041-111504
Stuebs FA, Schulmeyer CE, Mehlhorn G, Gass P, Kehl S, Renner SK, Renner SP, Geppert C, Adler W, Hartmann A, Beckmann MW, Koch MC. Accuracy of colposcopy-directed biopsy in detecting early cervical neoplasia: a retrospective study. Arch Gynecol Obstet. 2019 Feb;299(2):525-532.
DOI: https://doi.org/10.1007/s00404-018-4953-8
Barker B, Garcia F, Lozevski J, Warner J, Hatch K. The correlation between colposcopically directed cervical biopsy and loop electrosurgical excision procedure pathology and the effect of time on that agreement. Gynecol Oncol. 2001 Jul;82(1):22-6.
DOI: https://doi.org/10.1006/gyno.2001.6245
Denton KJ, Herbert A, Turnbull LS, Waddell C, Desai MS, Rana DN, Dudding N, Smith JH; British Society of Clinical Cytology. The revised BSCC terminology for abnormal cervical cytology. Cytopathology. 2008 Jun;19(3):137-57.
DOI: https://doi.org/10.1111/j.1365-2303.2008.00585.x
Bossuyt PM, Reitsma JB, Bruns DE, Gatsonis CA, Glasziou PP, Irwig LM, Lijmer JG, Moher D, Rennie D, de Vet HC; Standards for Reporting of Diagnostic Accuracy. Toward complete and accurate reporting of studies of diagnostic accuracy. The STARD initiative. Am J Clin Pathol. 2003 Jan;119(1):18-22.
DOI: https://doi.org/10.1309/8EXCCM6YR1THUBAF
Bonardi R, Cecchini S, Grazzini G, Ciatto S. Loop electrosurgical excision procedure of the transformation zone and colposcopically directed punch biopsy in the diagnosis of cervical lesions. Obstet Gynecol. 1992 Dec;80(6):1020-2.
Heatley MK, Bury JP. The correlation between the grade of dyskaryosis on cervical smear, grade of cervical intraepithelial neoplasia (CIN) on punch biopsy and the final histological diagnosis on cone biopsies of the cervix. Cytopathology. 1998 Apr;9(2):93-9 Berek JS. Novak's Gynecology. Lippincott Williams & Wilkins; 13th edition 2002. p. 471.
DOI: https://doi.org/10.1046/j.1365-2303.1998.00094.x
Murta EF, Conti R, Rodovalho J, Barcelos AC, Adad SJ, de Souza H. Outcome after treatment of high-grade squamous intraepithelial lesions: relation between colposcopically directed biopsy, conization and cervical loop excision. Eur J Gynaecol Oncol. 2004;25(5):587-90.
Sørbye SW, Arbyn M, Fismen S, Gutteberg TJ, Mortensen ES. HPV E6/E7 mRNA testing is more specific than cytology in post-colposcopy follow-up of women with negative cervical biopsy. PLoS One. 2011;6(10):e26022. Epub 2011 Oct 6.
DOI: https://doi.org/10.1371/journal.pone.0026022
Underwood M, Arbyn M, Parry-Smith W, De Bellis-Ayres S, Todd R, Redman CW, Moss EL. Accuracy of colposcopy-directed punch biopsies: a systematic review and meta-analysis. BJOG. 2012 Oct;119(11):1293-301. Epub 2012 Aug 13.
DOI: https://doi.org/10.1111/j.1471-0528.2012.03444.x
Zuchna C, Hager M, Tringler B, Georgoulopoulos A, Ciresa-Koenig A, Volgger B, Widschwendter A, Staudach A. Diagnostic accuracy of guided cervical biopsies: a prospective multicenter study comparing the histopathology of simultaneous biopsy and cone specimen. Am J Obstet Gynecol. 2010 Oct;203(4):321.e1-6. Epub 2010 Jul 14.
DOI: https://doi.org/10.1016/j.ajog.2010.05.033
Kim SI, Kim SJ, Suh DH, Kim K, No JH, Kim YB. Pathologic discrepancies between colposcopy-directed biopsy and loop electrosurgical excision procedure of the uterine cervix in women with cytologic high-grade squamous intraepithelial lesions. J Gynecol Oncol. 2020 Mar;31(2):e13. Epub 2019 Aug 22.
DOI: https://doi.org/10.3802/jgo.2020.31.e13
Noothong S, Inthasorn P, Warnnissorn M. Pathological discrepancy between colposcopic directed cervical biopsy and Loop Electrosurgical-Excision Procedures (LEEPs) in patients with biopsies proven high grade cervical intraepithelial neoplasia. Taiwan J Obstet Gynecol. 2017 Oct;56(5):628-631.
DOI: https://doi.org/10.1016/j.tjog.2017.08.009
Sadler L, Saftlas A, Wang W, Exeter M, Whittaker J, McCowan L. Treatment for cervical intraepithelial neoplasia and risk of preterm delivery. JAMA. 2004 May 5;291(17):2100-6.
DOI: https://doi.org/10.1001/jama.291.17.2100
Kyrgiou M, Athanasiou A, Kalliala IEJ, Paraskevaidi M, Mitra A, Martin-Hirsch PP, Arbyn M, Bennett P, Paraskevaidis E. Obstetric outcomes after conservative treatment for cervical intraepithelial lesions and early invasive disease. Cochrane Database Syst Rev. 2017 Nov 2;11(11):CD012847.
DOI: https://doi.org/10.1002/14651858.CD012847
Nagelhout G, Ebisch RM, Van Der Hel O, Meerkerk GJ, Magnée T, De Bruijn T, Van Straaten B. Is smoking an independent risk factor for developing cervical intra-epithelial neoplasia and cervical cancer? A systematic review and meta-analysis. Expert Rev Anticancer Ther. 2021 Jul;21(7):781-794. Epub 2021 Mar 5.
DOI: https://doi.org/10.1080/14737140.2021.1888719
Aguayo F, Muñoz JP, Perez-Dominguez F, Carrillo-Beltrán D, Oliva C, Calaf GM, Blanco R, Nuñez-Acurio D. High-Risk Human Papillomavirus and Tobacco Smoke Interactions in Epithelial Carcinogenesis. Cancers (Basel). 2020 Aug 6;12(8):2201.
DOI: https://doi.org/10.3390/cancers12082201
Jung Y, Lee AR, Lee SJ, Lee YS, Park DC, Park EK. Clinical factors that affect diagnostic discrepancy between colposcopically directed biopsies and loop electrosurgical excision procedure conization of the uterine cervix. Obstet Gynecol Sci. 2018 Jul;61(4):477-488. Epub 2018 Jun 28.
DOI: https://doi.org/10.5468/ogs.2018.61.4.477
Kuehn BM. Dramatic Cervical Cancer Screening Decline During Pandemic. JAMA. 2021 Mar 9;325(10):925.
DOI: https://doi.org/10.1001/jama.2021.1977
Molina MA, Carosi Diatricch L, Castany Quintana M, Melchers WJ, Andralojc KM. Cervical cancer risk profiling: molecular biomarkers predicting the outcome of hrHPV infection. Expert Rev Mol Diagn. 2020 Nov;20(11):1099-1120. Epub 2020 Oct 25.
DOI: https://doi.org/10.1080/14737159.2020.1835472
Gates A, Pillay J, Reynolds D, Stirling R, Traversy G, Korownyk C, Moore A, Thériault G, Thombs BD, Little J, Popadiuk C, van Niekerk D, Keto-Lambert D, Vandermeer B, Hartling L. Screening for the prevention and early detection of cervical cancer: protocol for systematic reviews to inform Canadian recommendations. Syst Rev. 2021 Jan 2;10(1):2.
DOI: https://doi.org/10.1186/s13643-020-01538-9
How to Cite
Nassiri, S., Aminimoghaddam, S., Sadaghian, M. R., Nikandish, M., Jamshidnezhad, N., & Saffarieh, E. (2022). Evaluation of the diagnostic accuracy of the cervical biopsy under colposcopic vision. European Journal of Translational Myology, 32(4). https://doi.org/10.4081/ejtm.2022.10670
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