Therapeutic effectiveness of green tea leaf extract on clinical symptoms in children suffering viral gastroenteritis: A randomized clinical trial

Submitted: 7 May 2022
Accepted: 25 May 2022
Published: 5 July 2022
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The use of tea plant extract has been reported to reduce viral complications, but its role in improving viral gastritis has not been investigated. The aim of this randomized clinical trial was to evaluate the effect of green tea consumption in improving pediatric viral gastroenteritis. This clinical trial study was performed on children aged 12 to 17 years with diarrhea who were not treated within 48 hours of the onset of clinical symptoms during September 2019 to September 2020. The children were randomly assigned to a green tea leaf extract (GTE) tablet. The placebo group was considered as a control. Treatment (prescribing the tablets) was continued until a Bristol Stool Scale of 3 or 4 was obtained. Two groups were compared in terms of clinical symptoms. The complete and partial improvement was revealed in 63.2% and 31.6% respectively in the GTE group while only in 15.8% and 57.9% respectively in control group indicating a significant difference (p <0.001). The increase in the number of tablets led to higher improvement rate in response to GTE prescription. The mean hospital stay in GTE and control groups was also 1.66 ± 0.63 days and 3.36 ± 0.4 days indicated shorter hospitalization in former group (p < 0.001). The use of GTE leads to effectively improve the diarrhea as well as to reduce the hospital stay in children suffering viral gastroenteritis.

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Fang Y, Zhang Y, Wang H, Shi O, Wang W, Hou M, Wang L, Wu J, Zhao Y. Molecular epidemiology of norovirus infections in children with acute gastroenteritis in 2017-2019 in Tianjin, China. J Med Virol. 2022 Feb;94(2):616-624. Epub 2021 Oct 1. DOI: https://doi.org/10.1002/jmv.27340
Mohammad HA, Madi NM, Al-Nakib W. Analysis of viral diversity in stool samples from infants and children with acute gastroenteritis in Kuwait using Metagenomics approach. Virol J. 2020 Jan 30;17(1):10. DOI: https://doi.org/10.1186/s12985-020-1287-5
Thwiny HT, Alsalih NJ, Saeed ZF, Al-Yasari AMR, Al-Saadawe MAA, Alsaadawi MAE. Prevalence and seasonal pattern of enteric viruses among hospitalized children with acute gastroenteritis in Samawah, Iraq. J Med Life. 2022;15:52-7.
Stuempfig ND, Seroy J. Viral Gastroenteritis. 2021 Jun 24. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022.
Iro MA, Sell T, Brown N, Maitland K. Rapid intravenous rehydration of children with acute gastroenteritis and dehydration: a systematic review and meta-analysis. BMC Pediatr. 2018;18:44. DOI: https://doi.org/10.1186/s12887-018-1006-1
Anheyer D, Frawley J, Koch AK, Lauche R, Langhorst J, Dobos G, Cramer H. Herbal Medicines for Gastrointestinal Disorders in Children and Adolescents: A Systematic Review. Pediatrics. 2017 Jun;139(6):e20170062. Epub 2017 May 4. DOI: https://doi.org/10.1542/peds.2017-0062
Horvath A, Dziechciarz P, Szajewska H. Systematic review of randomized controlled trials: fiber supplements for abdominal pain-related functional gastrointestinal disorders in childhood. Ann Nutr Metab. 2012;61:95-101. DOI: https://doi.org/10.1159/000338965
Yuan R, Lin Y. Traditional Chinese medicine: an approach to scientific proof and clinical validation. Pharmacol Ther. 2000;86:191-8. DOI: https://doi.org/10.1016/S0163-7258(00)00039-5
Zargari, A. “Medicinal Plants (in Persian),” Tehran University Press, Tehran, 1990.
McNaught J. On the action of cold or lukewarm tea on Bacillus typhosus. BMJ Military Health. 1906;7:372-3. https://militaryhealth.bmj.com/content/7/4/372
Ishihara N, Chu D-C, Akachi S, Juneja L. Improvement of intestinal microflora balance and prevention of digestive and respiratory organ diseases in calves by green tea extracts. Livestock Production Science. 2001;68:217-29. DOI: https://doi.org/10.1016/S0301-6226(00)00233-5
Liu J, Bodnar BH, Meng F, Khan AI, Wang X, Saribas S, Wang T, Lohani SC, Wang P, Wei Z, Luo J, Zhou L, Wu J, Luo G, Li Q, Hu W, Ho W. Epigallocatechin gallate from green tea effectively blocks infection of SARS-CoV-2 and new variants by inhibiting spike binding to ACE2 receptor. Cell Biosci. 2021 Aug 30;11(1):168. DOI: https://doi.org/10.1186/s13578-021-00680-8
Ishimoto K, Hatanaka N, Otani S, Maeda S, Xu B, Yasugi M, Moore JE, Suzuki M, Nakagawa S, Yamasaki S. Tea crude extracts effectively inactivate severe acute respiratory syndrome coronavirus 2. Lett Appl Microbiol. 2022 Jan;74(1):2-7. Epub 2021 Nov 5. DOI: https://doi.org/10.1111/lam.13591
Ide K, Yamada H, Kawasaki Y. Effect of gargling with tea and ingredients of tea on the prevention of influenza infection: a meta-analysis. BMC Public Health. 2016;16:396. DOI: https://doi.org/10.1186/s12889-016-3083-0
Jang M, Park YI, Cha YE, Park R, Namkoong S, Lee JI, Park J. Tea Polyphenols EGCG and Theaflavin Inhibit the Activity of SARS-CoV-2 3CL-Protease In Vitro. Evid Based Complement Alternat Med. 2020 Sep 16;2020:5630838. DOI: https://doi.org/10.1155/2020/5630838
Randazzo W, Falcó I, Aznar R, Sánchez G. Effect of green tea extract on enteric viruses and its application as natural sanitizer. Food Microbiol. 2017;66:150-6. DOI: https://doi.org/10.1016/j.fm.2017.04.018
Randazzo W, Costantini V, Morantz EK, Vinjé J. Human Intestinal Enteroids to Evaluate Human Norovirus GII.4 Inactivation by Aged-Green Tea. Front Microbiol. 2020;11:1917. DOI: https://doi.org/10.3389/fmicb.2020.01917
Chang LK, Wei TT, Chiu YF, Tung CP, Chuang JY, Hung SK, Li C, Liu ST. Inhibition of Epstein-Barr virus lytic cycle by (-)-epigallocatechin gallate. Biochem Biophys Res Commun. 2003 Feb 21;301(4):1062-8. DOI: https://doi.org/10.1016/S0006-291X(03)00067-6
Weber JM, Ruzindana-Umunyana A, Imbeault L, Sircar S. Inhibition of adenovirus infection and adenain by green tea catechins. Antiviral Res. 2003;58:167-73. DOI: https://doi.org/10.1016/S0166-3542(02)00212-7
Zehtabian S. The Antiviral Effect of Melissa Botany Extract on Proliferation of Rotavirus Causing Acute Gastroenteritis. Qom University of Medical Sciences Journal. 2015;8:10-6. URL: http://journal.muq.ac.ir/article-1-195-en.html
Colpitts CC, Schang LM. A small molecule inhibits virion attachment to heparan sulfate- or sialic acid-containing glycans. J Virol. 2014;88:7806-17. DOI: https://doi.org/10.1128/JVI.00896-14
Rondanelli M, Riva A, Petrangolini G, Allegrini P, Perna S, Faliva MA, Peroni G, Naso M, Nichetti M, Perdoni F, Gasparri C. Effect of Acute and Chronic Dietary Supplementation with Green Tea Catechins on Resting Metabolic Rate, Energy Expenditure and Respiratory Quotient: A Systematic Review. Nutrients. 2021 Feb 17;13(2):644. DOI: https://doi.org/10.3390/nu13020644

How to Cite

Sadeghian, M., Torabi, A., Torabi, S., Vafadar, M., & Oladi, S. (2022). Therapeutic effectiveness of green tea leaf extract on clinical symptoms in children suffering viral gastroenteritis: A randomized clinical trial. European Journal of Translational Myology, 32(3). https://doi.org/10.4081/ejtm.2022.10606