https://doi.org/10.4081/ejtm.2022.10453
Association of vitamin D and severity of COVID-19 in children
Submitted: 9 March 2022
Accepted: 13 March 2022
Published: 20 April 2022
Accepted: 13 March 2022
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All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Authors
Vitamin has a major role in the functions of the immune system, and the efficacy of this vitamin in reducing inflammation has been identified. Considering the effects of vitamin D, this study research was performed for investigating the relationship between vitamin D and the severity of COVID-19 in children. This cross-sectional study was performed on 101 children infected with the new coronavirus from September 2020 to October 2021. Information on vitamin D levels, demographic factors, and clinical and laboratory findings were documented in information forms and prepared for statistical analyses. The average of children was 2.85 ± 0.85 years. Low oxygen saturation was observed in 35.3% of infected children. The level of involvement was higher in subjects with vitamin D levels higher than 30 and less than 10 ng/ml (p = 0.04). Clinical signs in cases with deficient and sufficient vitamin D levels were more severe in terms of tachypnea and tachycardia (p = 0.01). Children with vitamin D lower than 10 ng/ml showed more frequency (p = 0.02). Cases with moderate vitamin D had fewer gastrointestinal complications (p = 0.03). Also, oxygen levels were lower in children who had low levels of vitamin D (p = 0.02). Vitamin D levels were associated with levels of involvement, tachycardia, tachypnea, clinical signs, gastrointestinal problems, and O2 levels. Moderate vitamin D levels in children are a critical issue that should be considered.
Zumla A, Hui DS, Perlman S. Middle East respiratory syndrome. Lancet. 2015 Sep 5;386(9997):995-1007. Epub 2015 Jun 3.
DOI: https://doi.org/10.1016/S0140-6736(15)60454-8
Cascella M, Rajnik M, Cuomo A, Dulebohn SC, Napoli RD. Evaluation and Treatment Coronavirus (COVID-19) [Updated 2020 Mar 20]. In StatPearls; StatPearls: Petersburg, FL, USA, 2020.
Peiris JS. Severe Acute Respiratory Syndrome (SARS). J Clin Virol. 2003;28(3):245-247.
DOI: https://doi.org/10.1016/j.jcv.2003.08.005
Imperial College London. Report 2: estimating the potential total number of novel coronavirus cases in Wuhan City, China. Jan 2020. https://www .imperial.ac.uk/mrc-globalinfectiousdisease-analysis/news--wuhan-coronavirus.
Yin Y, Wunderink RG. MERS, SARS and other coronaviruses as causes of pneumonia. Respirology. 2018 Feb;23(2):130-137. Epub 2017 Oct 20.
DOI: https://doi.org/10.1111/resp.13196
Cruz A, Zeichner S. COVID-19 in children: initial characterization of the pediatric disease. Pediatrics. 2020; doi: 10.1542/peds.2020-0834.
DOI: https://doi.org/10.1542/peds.2020-0834
Tabrizi R, Moosazadeh M, Akbari , Dabbaghmanesh MH, Mohamadkhani M, Asemi Z, et al. High prevalence of vitamin D deficiency among Iranian population: a systematic review and meta-analysis. Iran J Med Sci 2018; 43(2): 125-139 (Persian).
Nadiger M, Hassor S, Totapally B. Vitamin d levels in children with COVID-19 admitted to the PICU. Critical Care Medicine. 49 (SUPPL 1):54, 2021.
DOI: https://doi.org/10.1097/01.ccm.0000726440.30551.47
Schwalfenberg GK. A review of the critical role of vitamin D in the functioning of the immune system and the clinical implications of vitamin D deficiency. Mol Nutr Food Res. 2011 Jan;55(1):96-108. Epub 2010 Sep 7.
DOI: https://doi.org/10.1002/mnfr.201000174
Rondanelli, M.; Miccono, A.; Lamburghini, S.; Avanzato, I.; Riva, A.; Allegrini, P.; Faliva, M.A.; Peroni, G.; Nichetti, M.; Perna, S. Self-Care for Common Colds: The Pivotal Role of Vitamin D, Vitamin C, Zinc, and Echinacea in Three Main Immune Interactive Clusters (Physical Barriers, Innate and Adaptive Immunity) Involved during an Episode of Common Colds-Practical Advice on Dosages and on the Time to Take These Nutrients/Botanicals in order to Prevent or Treat Common Colds. Evid Based Complement Alternat Med.2018, 2018, 5813095.
DOI: https://doi.org/10.1155/2018/5813095
Holick MF. Vitamin D deficiency. N Engl J Med. 2007 Jul 19;357(3):266-81.
DOI: https://doi.org/10.1056/NEJMra070553
Rossi GA, Fanous H, Colin AA. Viral strategies predisposing to respiratory bacterial superinfections. Pediatr Pulmonol. 2020 Apr;55(4):1061-1073. Epub 2020 Feb 21.
DOI: https://doi.org/10.1002/ppul.24699
Sharifi A, Vahedi H, Nedjat S, Rafiei H, Hosseinzadeh-Attar MJ. Effect of single-dose injection of vitamin D on immune cytokines in ulcerative colitis patients: a randomized placebo-controlled trial. APMIS. 2019 Oct;127(10):681-687. Epub 2019 Jul 26.
DOI: https://doi.org/10.1111/apm.12982
Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, Zhang L, Fan G, Xu J, Gu X, Cheng Z, Yu T, Xia J, Wei Y, Wu W, Xie X, Yin W, Li H, Liu M, Xiao Y, Gao H, Guo L, Xie J, Wang G, Jiang R, Gao Z, Jin Q, Wang J, Cao B. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020 Feb 15;395(10223):497-506. Epub 2020 Jan 24. Erratum in: Lancet. 2020 Jan 30.
DOI: https://doi.org/10.1016/S0140-6736(20)30183-5
Gombart AF, Pierre A, Maggini S. A Review of Micronutrients and the Immune System-Working in Harmony to Reduce the Risk of Infection. Nutrients. 2020 Jan 16;12(1):236.
DOI: https://doi.org/10.3390/nu12010236
Wang D, Hu B, Hu C, Zhu F, Liu X, Zhang J, Wang B, Xiang H, Cheng Z, Xiong Y, Zhao Y, Li Y, Wang X, Peng Z. Clinical Characteristics of 138 Hospitalized Patients with 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China. JAMA. 2020 Mar 17;323(11):1061-1069. Erratum in: JAMA. 2021 Mar 16;325(11):1113.
DOI: https://doi.org/10.1001/jama.2020.1585
Azadeh H, Hedayatizadeh-Omran A, Saeedi M, Vahedi-Larijani L, Mehravaran H, Heydari K. Serum Vitamin D Concentrations in CoVID19 Patients. J Mazandaran Univ Med Sci. 2021; 31 (195) :30-36. URL: http://jmums.mazums.ac.ir /article-1-16104-en.html
Weir EK, Thenappan T, Bhargava M, Chen Y. Does vitamin D deficiency increase the severity of COVID-19?. Clin Med (Lond). 2020;20(4):e107-e108.
DOI: https://doi.org/10.7861/clinmed.2020-0301
Yılmaz K, Şen V. Is vitamin D deficiency a risk factor for COVID-19 in children?. Pediatr Pulmonol. 2020;55(12):3595-3601.
DOI: https://doi.org/10.1002/ppul.25106
Camargo CA Jr, Ganmaa D, Frazier AL, et al. Randomized trial of vitamin D supplementation and risk of acute respiratory infection in Mongolia. Pediatrics. 2012;130(3):e561–e567.
DOI: https://doi.org/10.1542/peds.2011-3029
Gavriela AFeketea, Vasiliki Vlacha, Bocsan Ioana Corina, et al . Vitamin D in Corona Virus Disease 2019 (COVID-19) Related Multisystem Inflammatory Syndrome in Children. Frontiers in Immunology. 2021:12. 607.
DOI: https://doi.org/10.3389/fimmu.2021.648546
Munshi R, Hussein MH, Toraih EA, Elshazli RM, Jardak C, Sultana N, et al. Vitamin D insufficiency as a potential culprit in critical COVID-19 patients. J Med Virol. 2021;93:733–40.
DOI: https://doi.org/10.1002/jmv.26360
Merzon E, Tworowski D, Gorohovski A, Vinker S, Cohen AG, Green I, et al. Low plasma 25(OH) vitamin D level is associated with increased risk of COVID-19 infection: an Israeli population-based study. FEBS J. 2020;287:3693–702.
DOI: https://doi.org/10.1111/febs.15495
Maghbooli Z, Sahraian MA, Ebrahimi M, Pazoki M, Kafan S, Tabriz HM, et al. Vitamin D sufficiency, a serum 25-hydroxyvitamin D at least 30 ng/mL reduced risk for adverse clinical outcomes in patients with COVID-19 infection. PLoS ONE. 2020;15:e0239799.
DOI: https://doi.org/10.1371/journal.pone.0239799
Güven M, Gültekin H. The effect of high-dose parenteral vitamin D3 on COVID-19-related inhospital mortality in critical COVID-19 patients during intensive care unit admission: an observational cohort study. Eur J Clin Nutr. 2021 Sep;75(9):1383-1388. Epub 2021 Jul 23.
DOI: https://doi.org/10.1038/s41430-021-00984-5
Hastie CE, Pell JP, Sattar N. Vitamin D and COVID-19 infection and mortality in UK Biobank. Eur J Nutr. 2021;60(1):545-548.
DOI: https://doi.org/10.1007/s00394-020-02372-4
Laaksi I. Vitamin D and respiratory infection in adults. Proc Nutr Soc. 2012 Feb;71(1):90-7. Epub 2011 Nov 25.
DOI: https://doi.org/10.1017/S0029665111003351
Chen G, Wu D, Guo W, Cao Y, Huang D, Wang H, Wang T, Zhang X, Chen H, Yu H, Zhang X, Zhang M, Wu S, Song J, Chen T, Han M, Li S, Luo X, Zhao J, Ning Q. Clinical and immunological features of severe and moderate coronavirus disease 2019. J Clin Invest. 2020 May 1;130(5):2620-2629.
DOI: https://doi.org/10.1172/JCI137244
Jafari R, Cegolon L, Torkaman M, Kashaki M, Dehghanpoor F, Cheraghalipoor F, Javanbakht M. A 6 months old infant with fever, dyspnea and poor feeding, diagnosed with COVID-19. Travel Med Infect Dis. 2020 Jul-Aug;36:101789. Epub 2020 Jun 12.
DOI: https://doi.org/10.1016/j.tmaid.2020.101789
Panfili FM, Roversi M, D'Argenio P, Rossi P, Cappa M, Fintini D. Possible role of vitamin D in Covid-19 infection in pediatric population. J Endocrinol Invest. 2021 Jan;44(1):27-35. Epub 2020 Jun 15.
DOI: https://doi.org/10.1007/s40618-020-01327-0
Shafiee S, Cegolon L, Khafaei M, Gholami N, Zhao S, Khalesi N, Moosavian H, Fathi S, Izadi M, Ghadian A, Javanbakht M, Javanbakht A, Akhavan-Sigari R. Gastrointestinal cancers, ACE-2/TMPRSS2 expression and susceptibility to COVID-19. Cancer Cell Int. 2021 Aug 16;21(1):431.
DOI: https://doi.org/10.1186/s12935-021-02129-x
Yu L, Ke HJ, Che D, Luo SL, Guo Y, Wu JL. Effect of Pandemic-Related Confinement on Vitamin D Status Among Children Aged 0-6 Years in Guangzhou, China: A Cross-Sectional Study. Risk Manag Healthc Policy. 2020 Nov 19;13:2669-2675.
DOI: https://doi.org/10.2147/RMHP.S282495
How to Cite
Karimian, P., Tahami, M. S., Sayyahfar, S., & Aghajani Delavar, M. (2022). Association of vitamin D and severity of COVID-19 in children. European Journal of Translational Myology, 32(2). https://doi.org/10.4081/ejtm.2022.10453
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