Clinical features predicting COVID-19 mortality risk

Submitted: 5 November 2021
Accepted: 23 November 2021
Published: 12 April 2022
Abstract Views: 5772
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Currently, the world is involved by a pandemic of severe acute respiratory syndrome coronavirus 2 (SARS CoV-2), which has been responsible for the deaths of hundreds of thousands of people so far. The consequences of infection with SARS-CoV-2 vary widely from asymptomatic to severe. Considering the increasing prevalence of different types of virus and acute infection with this disease, strategies to prevent mortality from COVID-19 should be seriously analyzed. In this study, the epidemiological, clinical and laboratory characteristics of patients with COVID-19 were investigated in order to identify risk factors for mortality. Chronic diseases such as chronic kidney disease (CKD), COPD, diabetes, hypertension, cardiovascular disease (CVD), cancer, increased D-dimer, male gender, old age, smoking and obesity are among the deadly risk factors associated COVID-19. Furthermore, lymphopenia and neutrophilia are often present in patients with SARS-CoV-2, and the ratio of absolute neutrophils to lymphocytes (NLR) was significantly increased in patients without bacterial infection. These findings could be used in the future to control and prevent disease, because timely identification of patients with risk of COVID-19 is important to provide better treatment strategies for reduction of mortality.

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Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, Zhang L, Fan G, Xu J, Gu X, Cheng Z, Yu T, Xia J, Wei Y, Wu W, Xie X, Yin W, Li H, Liu M, Xiao Y, Gao H, Guo L, Xie J, Wang G, Jiang R, Gao Z, Jin Q, Wang J, Cao B. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020 Feb 15;395(10223):497-506. DOI: https://doi.org/10.1016/S0140-6736(20)30183-5
Li Q, Guan X, Wu P, Wang X, Zhou L, Tong Y, Ren R, Leung KSM, Lau EHY, Wong JY, Xing X, Xiang N, Wu Y, Li C, Chen Q, Li D, Liu T, Zhao J, Liu M, Tu W, Chen C, Jin L, Yang R, Wang Q, Zhou S, Wang R, Liu H, Luo Y, Liu Y, Shao G, Li H, Tao Z, Yang Y, Deng Z, Liu B, Ma Z, Zhang Y, Shi G, Lam TTY, Wu JT, Gao GF, Cowling BJ, Yang B, Leung GM, Feng Z. Early Transmission Dynamics in Wuhan, China, of Novel Coronavirus-Infected Pneumonia. N Engl J Med. 2020 Mar 26;382(13):1199-1207. DOI: https://doi.org/10.1056/NEJMoa2001316
Mehta P, McAuley DF, Brown M, Sanchez E, Tattersall RS, Manson JJ; HLH Across Speciality Collaboration, UK. COVID-19: consider cytokine storm syndromes and immunosuppression. Lancet. 2020 Mar 28;395(10229):1033-1034. DOI: https://doi.org/10.1016/S0140-6736(20)30628-0
Genc Yavuz B, Colak S, Guven R, Altundag İ, Seyhan AU, Gunay Inanc R. Clinical Features of the 60 Years and Older Patients Infected with 2019 Novel Coronavirus: Can We Predict Mortality Earlier? Gerontology. 2021;67(4):433-440. DOI: https://doi.org/10.1159/000514481
De Vito A, Geremia N, Fiore V, Princic E, Babudieri S, Madeddu G. Clinical features, laboratory findings and predictors of death in hospitalized patients with COVID-19 in Sardinia, Italy. Eur Rev Med Pharmacol Sci. 2020 Jul;24(14):7861-7868.
Vaira LA, Deiana G, Fois AG, Pirina P, Madeddu G, De Vito A, Babudieri S, Petrocelli M, Serra A, Bussu F, Ligas E, Salzano G, De Riu G. Objective evaluation of anosmia and ageusia in COVID-19 patients: Single-center experience on 72 cases. Head Neck. 2020 Jun;42(6):1252-1258. DOI: https://doi.org/10.1002/hed.26204
Faria SS, Fernandes PC Jr, Silva MJ, Lima VC, Fontes W, Freitas-Junior R, Eterovic AK, Forget P. The neutrophil-to-lymphocyte ratio: a narrative review. Ecancermedicalscience. 2016 Dec 12;10:702. DOI: https://doi.org/10.3332/ecancer.2016.702
Sigurdsson B. A new clinical entity? Lancet 1956;267:789–790. DOI: https://doi.org/10.1016/S0140-6736(56)91252-1
Boffey P. Fatigue ‘Virus’ Has Experts More Baffled and Skeptical Than Ever. New York, NY: New York Times .1987. Available online at: www.nytimes.com/1987/07/28/science/fatigue-virus-has-experts-morebaffled- and-skeptical-than-ever.html (accessed July 28, 1987).
Steinbrook R. 160 Victims at Lake Tahoe: Chronic Flu-Like Illness a Medical Mystery Story. Los Angeles, CA: Los Angeles Times. 1986 Available online at: http://articles.latimes.com/1986-06-07/news/mn-9956_ 1_lake-tahoe (Accessed June 7, 1986).
Hyde B. The Clinical and Scientific Basis of ME/CFS. Ottawa, ON: Nightingale Research Foundation ,1992.
Lu R, Zhao X, Li J, Niu P, Yang B, Wu H, Wang W, Song H, Huang B, Zhu N, Bi Y, Ma X, Zhan F, Wang L, Hu T, Zhou H, Hu Z, Zhou W, Zhao L, Chen J, Meng Y, Wang J, Lin Y, Yuan J, Xie Z, Ma J, Liu WJ, Wang D, Xu W, Holmes EC, Gao GF, Wu G, Chen W, Shi W, Tan W. Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding. Lancet. 2020 Feb 22;395(10224):565-574. DOI: https://doi.org/10.1016/S0140-6736(20)30251-8
Zhou P, Yang XL, Wang XG, Hu B, Zhang L, Zhang W, Si HR, Zhu Y, Li B, Huang CL, Chen HD, Chen J, Luo Y, Guo H, Jiang RD, Liu MQ, Chen Y, Shen XR, Wang X, Zheng XS, Zhao K, Chen QJ, Deng F, Liu LL, Yan B, Zhan FX, Wang YY, Xiao GF, Shi ZL. A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature. 2020 Mar;579(7798):270-273. DOI: https://doi.org/10.1038/s41586-020-2012-7
Pradyumna P, Ritika P. Chronic Fatigue Syndrome After COVID-19 Infection: A Call for Action. Erciyes Med J 2021; 43(1): 98–9
Wu F, Zhao S, Yu B, Chen YM, Wang W, Song ZG. A new coronavirus associated with human respiratory disease in China. Nature. 2020. https://doi.org/10.1038/s41586-020-2008-3 [Epub ahead of print. DOI: https://doi.org/10.1038/s41586-020-2202-3
Farrell TW, Ferrante LE, Brown T, Francis L, Widera E, Rhodes R, Rosen T, Hwang U, Witt LJ, Thothala N, Liu SW, Vitale CA, Braun UK, Stephens C, Saliba D. AGS Position Statement: Resource Allocation Strategies and Age-Related Considerations in the COVID-19 Era and Beyond. J Am Geriatr Soc. 2020 Jun;68(6):1136-1142. DOI: https://doi.org/10.1111/jgs.16537
Osmani F. Analysis of students satisfaction with virtual education in Medical Science University during the pandemic outbreak of COVID-19. Int J Assess Tools Educ. 2021;8(1):1–8. DOI: https://doi.org/10.21449/ijate.854675
Nicholls JM, Poon LL, Lee KC, Ng WF, Lai ST, Leung CY, Chu CM, Hui PK, Mak KL, Lim W, Yan KW, Chan KH, Tsang NC, Guan Y, Yuen KY, Peiris JS. Lung pathology of fatal severe acute respiratory syndrome. Lancet. 2003 May 24;361(9371):1773-8. DOI: https://doi.org/10.1016/S0140-6736(03)13413-7
Chen J, Qi T, Liu L, Ling Y, Qian Z, Li T. Clinical progression of patients with COVID-19 in Shanghai, China. J Infect. 2020. DOI: https://doi.org/10.1016/j.jinf.2020.03.004
Li B, Yang J, Zhao F, Zhi L, Wang X, Liu L. Prevalence and impact of cardiovascular metabolic diseases on COVID-19 in China. Clin Res Cardiol. 2020;109(5):531-8. DOI: https://doi.org/10.1007/s00392-020-01626-9
Zhang XB, Hu L, Ming Q, Wei XJ, Zhang ZY, Chen LD, Wang MH, Yao WZ, Huang QF, Ye ZQ, Cai YQ, Zeng HQ. Risk factors for mortality of coronavirus disease-2019 (COVID-19) patients in two centers of Hubei province, China: A retrospective analysis. PLoS One. 2021 Jan 28;16(1):e0246030. DOI: https://doi.org/10.1371/journal.pone.0246030
Mehta HB, Li S, Goodwin JS. Risk Factors Associated With SARS-CoV-2 Infections, Hospitalization, and Mortality Among US Nursing Home Residents. JAMA Netw Open. 2021 Mar 1;4(3):e216315. DOI: https://doi.org/10.1001/jamanetworkopen.2021.6315
Dessie ZG, Zewotir T. Mortality-related risk factors of COVID-19: a systematic review and meta-analysis of 42 studies and 423,117 patients. BMC Infect Dis. 2021 Aug 21;21(1):855. DOI: https://doi.org/10.1186/s12879-021-06536-3
Scully EP, Haverfield J, Ursin RL, Tannenbaum C, Klein SL. Considering how biological sex impacts immune responses and COVID-19 outcomes. Nat Rev Immunol. 2020 Jul;20(7):442-447. DOI: https://doi.org/10.1038/s41577-020-0348-8
Hewagama A, Patel D, Yarlagadda S, Strickland FM, Richardson BC. Stronger inflammatory / cytotoxic T-cell response in women identified by microarray analysis. Genes Immun. 2009 Jul;10(5):509-16. DOI: https://doi.org/10.1038/gene.2009.12
Abdullah M, Chai PS, Chong MY, Tohit ER, Ramasamy R, Pei CP, Vidyadaran S. Gender effect on in vitro lymphocyte subset levels of healthy individuals. Cell Immunol. 2012;272(2):214-9. DOI: https://doi.org/10.1016/j.cellimm.2011.10.009
Hurst JR, Skolnik N, Hansen GJ, Anzueto A, Donaldson GC, Dransfield MT, Varghese P. Understanding the impact of chronic obstructive pulmonary disease exacerbations on patient health and quality of life. Eur J Intern Med. 2020 Mar;73:1-6. DOI: https://doi.org/10.1016/j.ejim.2019.12.014
Williams NP, Ostridge K, Devaster JM, Kim V, Coombs NA, Bourne S, Clarke SC, Harden S, Abbas A, Aris E, Lambert C, Tuck A, Williams A, Wootton S, Staples KJ, Wilkinson TMA; AERIS Study Group. Impact of radiologically stratified exacerbations: insights into pneumonia aetiology in COPD. Respir Res. 2018 Jul 28;19(1):143. DOI: https://doi.org/10.1186/s12931-018-0842-8
Fadini GP, Morieri ML, Longato E, Avogaro A. Prevalence and impact of diabetes among people infected with SARS-CoV-2. J Endocrinol Invest. 2020 Jun;43(6):867-869. DOI: https://doi.org/10.1007/s40618-020-01236-2
Wang B, Li R, Lu Z, Huang Y. Does comorbidity increase the risk of patients with COVID-19: evidence from meta-analysis. Aging (Albany NY). 2020 Apr 8;12(7):6049-6057. DOI: https://doi.org/10.18632/aging.103000
Zhou F, Yu T, Du R, Fan G, Liu Y, Liu Z, Xiang J, Wang Y, Song B, Gu X, Guan L, Wei Y, Li H, Wu X, Xu J, Tu S, Zhang Y, Chen H, Cao B. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet. 2020 Mar 28;395(10229):1054-1062. DOI: https://doi.org/10.1016/S0140-6736(20)30566-3
Shah S, Shah K, Patel SB, Patel FS, Osman M, Velagapudi P, Turagam MK, Lakkireddy D, Garg J. Elevated D-Dimer Levels Are Associated With Increased Risk of Mortality in Coronavirus Disease 2019: A Systematic Review and Meta-Analysis. Cardiol Rev. 2020 Nov/Dec;28(6):295-302. DOI: https://doi.org/10.1097/CRD.0000000000000330
Małecka-Giełdowska M, Fołta, M, Wi´sniewska A, Czyz˙ ewska E, Ciepiela O. Cell Population Data and Serum Polyclonal Immunoglobulin Free Light Chains in the Assessment of COVID-19 Severity. Viruses 202; 13;1381. DOI: https://doi.org/10.3390/v13071381
Bastola A, Shrestha S, Nepal R, Maharjan K, Shrestha B, Chalise BS, Thapa P, Balla P, Sapkota A, Shah P. Clinical Mortality Review of COVID-19 Patients at Sukraraj Tropical and Infectious Disease Hospital, Nepal; A Retrospective Study. Trop Med Infect Dis.2021; 6:137. DOI: https://doi.org/10.3390/tropicalmed6030137
Sepandi M, Taghdir M, Alimohamadi Y, Afrashteh S, Hosamirudsari H. Factors Associated with Mortality in COVID-19 Patients: A Systematic Review and Meta-Analysis. Iran J Public Health. 2020 Jul;49(7):1211-1221. DOI: https://doi.org/10.18502/ijph.v49i7.3574
Lee KH, Kim JS, Hong SH, Seong D, Choi YR, Ahn YT, Kim KS, Kim SE, Lee S, Sim W, Kim D, Jun B, Yang JW, Yon DK, Lee SW, Kim MS, Dragioti E, Li H, Jacob L, Koyanagi A, Abou Ghayda R, Shin JI, Smith L. Risk factors of COVID-19 mortality: a systematic review of current literature and lessons from recent retracted articles. Eur Rev Med Pharmacol Sci. 2020 Dec;24(24):13089-13097.
Małecka-Giełdowska M, Fołta M, Wiśniewska A, Czyżewska E, Ciepiela O. Cell Population Data and Serum Polyclonal Immunoglobulin Free Light Chains in the Assessment of COVID-19 Severity. Viruses. 2021 Jul 15;13(7):1381. DOI: https://doi.org/10.3390/v13071381
Ghasemian R, Alizadeh-Navaei R, Boskabadi J, Rezaei Kalantari K. Clinical Features and Paraclinical Findings of Patients Died of COVID-19 in a Referral Hospital in Sari, Iran, February 2020-May 2020. J Mazandaran Univ Med Sci. 2021; 31 (198) :119-132. Article in Persian.

How to Cite

Kouhpayeh, H. (2022). Clinical features predicting COVID-19 mortality risk. European Journal of Translational Myology, 32(2). https://doi.org/10.4081/ejtm.2022.10268