Rapid detection of cryptococcal antigen by a flow assay


https://doi.org/10.4081/mm.2017.6977
Vol. 32 No. 3 (2017)
Submitted: 4 August 2017
Accepted: 5 September 2017
Published: 10 October 2017
Cryptococcosis, antigen, LFA
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Cryptococcosis is a life-threatening infection caused by Cryptococcus neoformans and C. gattii. Tests for quick detection of the cryptococcal antigen are needed. This study compares the performance of a lateral flow assay (LFA) to the latex agglutination method. Thirty-five cryopreserved positive samples (sera and cerebrospinal fluids) plus three negative sera for control have been examined. LFA does not need high-temperature incubation or enzyme pre-treatment. All the results, except for one serum, agree with previous obtained with latex agglutination method. LFA has an important clinical utility for its rapidity and sensitivity, and it also can be used as a point-of-care test.

Bargiggia, G., Corbellini, S., Ortalli, G., Moioli, F., & Farina, C. (2017). Rapid detection of cryptococcal antigen by a flow assay. Microbiologia Medica, 32(3). https://doi.org/10.4081/mm.2017.6977

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