https://doi.org/10.4081/mm.2010.2482

In vitro activity of tigecycline against 313 Gram-positive and Gram-negative clinical isolates

Vol. 25 No. 1 (2010)
Submitted: 14 February 2014
Accepted: 14 February 2014
Published: 31 March 2010
tigecycline, broad-spectrum activity, antibiotic-resistance
Abstract Views: 1587
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Authors

Elisabetta Maioli
anna.marchese@unige.it
Erika Coppo
Ramona Barbieri
Elisabetta Canepa
Laura Gualco
Carla Pruzzo
Eugenio A. Debbia
Anna Marchese
Objectives. In this study the in vitro activity of tigecycline, member of a new class of antimicrobial agents, the glycylcyclines, was evaluated against clinical isolates collected in Italy. Study Design. A total of 313 clinical pathogens were collected and identified in our Institution during 2007-2008. Minimum inhibitory concentrations (MICs) of the antimicrobial agents were determined by the CLSI (2007) recommended broth microdilution method. Results. Globally 205 Gram-negative and 108 Gram-positive pathogens were evaluated.Tigecycline demonstrated excellent inhibitory activity against Acinetobacter spp., H. influenzae, E. coli, Enterococcus spp., S. aureus, S. agalactiae and S. pneumoniae with MIC90 ≤1mg/l. Conclusion. Tigecycline exhibited potent in vitro antibacterial activity (comparable to or greater than most commonly employed antimicrobials) against both Gram-positive and negative clinical pathogens.These data suggest that tigecycline, with an expanded broad-spectrum antimicrobial activity, may be an effective empiric therapeutic option for the treatment of serious infections caused by clinically relevant pathogens.

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How to Cite

Maioli, E., Coppo, E., Barbieri, R., Canepa, E., Gualco, L., Pruzzo, C., Debbia, E. A., & Marchese, A. (2010). In vitro activity of tigecycline against 313 Gram-positive and Gram-negative clinical isolates. Microbiologia Medica, 25(1). https://doi.org/10.4081/mm.2010.2482

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