https://doi.org/10.4081/mm.2011.2367

Evaluation of reactivation of HSV1, HHV6, CMV and EBV in a population of patients undergoing allogeneic bone marrow transplantation

Vol. 26 No. 2 (2011)
Submitted: 13 February 2014
Accepted: 13 February 2014
Published: 30 June 2011
Bone marrow transplantation, Herpes virus reactivation, aGVDH
Abstract Views: 1130
PDF: 1401
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Authors

Caterina Matinato
office@pagepress.org
Giovanna Lunghi
Anna Orlandi
Silvia Melotti
Antonella Zoccoli
Damiano Picicco
Erminio Torresani
Herpes viruses are recognized as important pathogens as a result of viral reactivation in immunocompromised hosts, especially in patients undergoing bone marrow transplantation. Objectives of this study were the assessment of the reactivation of herpes virus HSV1, HHV6, CMV and EBV and the correlation between viral reactivation and progression of transplantation in a population of patients undergoing allogeneic bone marrow transplantation at Fondazione IRCCS Ospedale Maggiore Ca’ Granda Policlinico, Milan. Viral DNA was detected and quantified by Real Time PCR in a population of 35 patients undergoing allogeneic bone marrow transplantation. The viral reactivation was observed in 7 patients for HSV1 (20%), 6 patients for HHV6 (17.1%), 11 patients for CMV (31.4%) and 4 patients for EBV (11.4%). Difference in the incidence of aGVDH between patients with viral reactivation versus those for which there was no reactivation was statistically significant. These data confirm the importance of monitoring viral load for the management of antiviral therapy in order to prevent CMV disease and complications related to herpes viruses reactivation.

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How to Cite

Matinato, C., Lunghi, G., Orlandi, A., Melotti, S., Zoccoli, A., Picicco, D., & Torresani, E. (2011). Evaluation of reactivation of HSV1, HHV6, CMV and EBV in a population of patients undergoing allogeneic bone marrow transplantation. Microbiologia Medica, 26(2). https://doi.org/10.4081/mm.2011.2367

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