https://doi.org/10.4081/jbr.2017.6210

Some hematological parameters of Wistar rats treated with Chromolaena odorata leave extracts

Vol. 90 No. 1 (2017)
Submitted: July 29, 2016
Accepted: March 30, 2017
Published: October 16, 2017
Chromolaena Odorata, Hematological parameters, Hematopoetic, Phytochemicals, Acute toxicity
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Authors

Henshaw Uchechi Okoroiwu
okoroiwuhenshaw@gmail.com
Haematology Unit, Department of Medical Laboratory Science University of Calabar, Calabar, Nigeria.
Ifeyinwa Maryann Okafor
Haematology Unit, Department of Medical Laboratory Science University of Calabar, Calabar, Nigeria.
Emmanuel Kufre Uko
Haematology Unit, Department of Medical Laboratory Science University of Calabar, Calabar, Nigeria.
Item Justin Atangwho
Department of Biochemistry University of Calabar, Calabar, Nigeria.
This study was designed to investigate the effects of the different extracts of Chromolaena odorata leave on the hematopoietic system of Wistar rats. Solvent extraction was used for the ethanol and aqueous extractions while decoction method was used for the crude extraction. Fifty Wistar rats of both sexes weighing 140-180 g were used for this study. They were divided into ten groups each containing five rats. The animals were fed the extracts by oral gavage once daily for 21 days. Blood sample was collected via cardiac artery. Hematological parameters were analyzed using automation method. The ethanol extract gave the highest extract yield. The aqueous, ethanol and crude extraction had median lethal toxicity (LD50) of 2738.6 mg/kg, 1581.1 mg/kg and 224.7 mg/kg, respectively. Significant difference (P<0.05) in the total white blood cell count was observed in the 75 mg/kg ethanol and 300 mg/kg crude extracts when compared with control group. Significant difference (P<0.05) in the hemoglobin concentration was observed in the 150 mg/kg ethanol extracts when compared with the control group. Significant difference (P<0.05) in the packed cell volume was seen in the 75 mg/kg aqueous, 150 mg/kg aqueous and 75 mg/kg ethanol extracts in respect to the control group. The mean cell volume, the mean platelet volume and platelet large cell ratio of the 75 mg/kg aqueous extract were significantly different (P<0.05) when compared with the control group. The present study showed possible treatment-induced hematopoietic function of C. odorata leave extracts.

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Supporting Agencies

research was sponsored by authors
Henshaw Uchechi Okoroiwu, Haematology Unit, Department of Medical Laboratory Science University of Calabar, Calabar
Ph.D student Haematology unit, department of medical laboratory science, university of calabar, nigeria
Ifeyinwa Maryann Okafor, Haematology Unit, Department of Medical Laboratory Science University of Calabar, Calabar
Professor of haematology
Emmanuel Kufre Uko, Haematology Unit, Department of Medical Laboratory Science University of Calabar, Calabar
Lecturer 1, Haematology unit, department of medical laboratory science, university of calabar, nigeria
Item Justin Atangwho, Department of Biochemistry University of Calabar, Calabar
Senior lecturer, department of biochemistry, university of calabar

How to Cite

Okoroiwu, H. U., Okafor, I. M., Uko, E. K., & Atangwho, I. J. (2017). Some hematological parameters of Wistar rats treated with Chromolaena odorata leave extracts. Journal of Biological Research - Bollettino Della Società Italiana Di Biologia Sperimentale, 90(1). https://doi.org/10.4081/jbr.2017.6210

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