Susceptibility to patterns of ciprofloxacin among nalidixic acid-resistant Salmonella isolates collected in Banepa, Nepal from enteric fever patients

Submitted: September 21, 2015
Accepted: September 15, 2016
Published: December 20, 2016
Abstract Views: 1308
PDF: 789
Publisher's note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.

Authors

The present study determined the susceptibility to ciprofloxacin of nalidixic acid resistant Salmonella (NARS) isolated from enteric fever patients at Scheer Memorial Hospital, Banepa, Nepal, from June 2012 to December 2012. The antimicrobial sensitivity to nalidixic acid and ciprofloxacin was determined using modified Kirby-Bauer disc diffusion and broth dilution method according to the guidelines of the Clinical and Laboratory Standard Institute. Salmonella was isolated from 34 out of 992 (3.43%) blood cultures collected during the study period, and 10 (29.4%) isolates were identified as Salmonella enterica serotype Typhi, while 24 (70.6%) were identified as Salmonella enterica serotype Paratyphi. Out of the total isolates, 31 (91.2%) were nalidixic acid-resistant Salmonella (NARS). Among NARS, the minimum inhibitory concentration values for ciprofloxacin ranged from 0.25 to 2 mg/L and were constantly higher than those shown by the nalidixic acid-susceptible Salmonella. Therefore, in typhoid Salmonella nalidixic acid resistance may be the indicator of decreased susceptibility to ciprofloxacin.

Dimensions

Altmetric

PlumX Metrics

Downloads

Download data is not yet available.

Citations

Girija Roka, Department of Microbiology, National College, Kathmandu
Lecturer, Dept. of Pharmacy

How to Cite

Roka, G., Pandaya, S., Ferdous, M. R.- ul, Pandey, M., Pokhrel, N. R., Shrestha, R., Alam, T. T., Billah, M. M., & Ahamed, S. K. (2016). Susceptibility to patterns of ciprofloxacin among nalidixic acid-resistant Salmonella isolates collected in Banepa, Nepal from enteric fever patients. Journal of Biological Research - Bollettino Della Società Italiana Di Biologia Sperimentale, 89(2). https://doi.org/10.4081/jbr.2016.5527