https://doi.org/10.4081/jbr.2014.2143

Arrhythmia susceptibility in senescent rat hearts

Vol. 87 No. 1 (2014): Proceedings of the 85th SIBS Congress
Submitted: November 21, 2013
Accepted: November 21, 2013
Published: January 10, 2014
aged heart, arrhythmia, epicardial mapping
Abstract Views: 1484
PDF: 1059
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Authors

Stefano Rossi
stefano.rossi@unipr.it
Department of Biosciences, University of Parma, Italy.
Silvana Baruffi
Department of Biosciences, University of Parma, Italy.
Domenico Corradi
Department of Biomedical, Biotechnological and Translational Sciences, University of Parma, Italy.
Sergio Callegari
Department of Cardiology, Vaio Hospital, Fidenza, Italy.
Ezio Musso
Department of Biosciences, University of Parma, Italy.
Andrea Sgoifo
Department of Neurosciences, University of Parma, Italy.
Luca Carnevali
Department of Neurosciences, University of Parma, Italy.
Michele Miragoli
Center of Excellence of Toxicological Research, University of Parma, Italy.
Emilio Macchi
Center of Excellence of Toxicological Research, University of Parma, Italy.
Cardiovascular disease increases with age as well as alterations of cardiac electrophysiological properties, but a detailed knowledge about changes in cardiac electrophysiology relevant to arrhythmogenesis in the elderly is relatively lacking. The aim of this study was to determine specific age-related changes in electrophysiological properties of the ventricles which can be related to a structural-functional arrhythmogenic substrate. Multiple epicardial electrograms were recorded on the ventricular surface of in vivo control and aged rats, while arrhythmia vulnerability was investigated by premature stimulation protocols. Single or multiple ectopic beats and sustained ventricular arrhythmias were frequently induced in aged but not in control hearts. Abnormal ventricular activation patterns during sinus rhythm and unchanged conduction velocity during point stimulation in aged hearts suggest the occurrence of impaired impulse conduction through the distal Purkinje system that might create a potential reentry substrate.

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Supporting Agencies

This research was supported by Fondazione CARIPARMA Grant 2006.0082, Grant September 2010 and Grant GR2009-1520528 Young Researcher Grant, Italian Ministry of Health to MM

How to Cite

Rossi, S., Baruffi, S., Corradi, D., Callegari, S., Musso, E., Sgoifo, A., Carnevali, L., Miragoli, M., & Macchi, E. (2014). Arrhythmia susceptibility in senescent rat hearts. Journal of Biological Research - Bollettino Della Società Italiana Di Biologia Sperimentale, 87(1). https://doi.org/10.4081/jbr.2014.2143

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