https://doi.org/10.4081/gc.2017.6682
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Non-invasive assessment of gastric secretory function in centenarians

Authors

Antonio Tursi
antotursi@tiscali.it
Gastroenterology Service, ASL BAT, Andria (BT), Italy.
Rudi De Bastiani
Primary Care Setting, Veneto Region, Italy.
Marilisa Franceschi
Digestive Endoscopy Unit, ULSS4 Alto Vicentino, Santorso, Schio (VI), Italy.
Elisabetta Goni
Department of Gastroenterology, Hepatology and Infectious Diseases, Otto-von-Guericke University Hospital, Magdeburg, Germany.
Matteo Riccò
Department of Health Prevention, Occupational Health & Search Unit, Trento, Italy.
Marino Venerito
Department of Gastroenterology, Hepatology and Infectious Diseases, Otto-von-Guericke University Hospital, Magdeburg, Germany.
Massimo Rugge
Department of Pathology, University of Padua, Padua, Italy.
Carmelo Scarpignato
Laboratory of Clinical Pharmacology, Division of Gastroenterology, University of Parma, Parma, Italy.
Marcello Picchio
Division of Surgery, P. Colombo Hospital, ASL RM6, Velletri (RM), Italy.
Francesco Di Mario
Department of Clinical & Experimental Medicine, Gastroenterology Unit, University of Parma, Parma, Italy.
the Primary Care collaborative group
Gastric acid secretion is believed to decrease in the aging stomach, but the number of elderly patients on proton pump inhibitor (PPI) therapy is increasing. The aim was to assess gastric function by means of serology (PGI, PGII, G17 and IgG antibodies against Helicobacter pylori) in centenarians. Twenty-five centenarians (2 males, 23 females, mean age 101.3 years, range 100- 106 years) underwent to serological gastric markers assessment by means of Gastropanel®. Patients with laboratory signs of severe oxyntic gastric atrophy (OGA) underwent gastroscopy with biopsy samples. Twelve patients (48.0%) had serological values according to normal gastric secretion; 3 patients (12%) had serological values according to severe OGA, confirmed by histology; 21 patients (84.0%) had serological values according to H. pylori infection. Acid secretion seems to be preserved in a large part of centenarians. Serological markers may be helpful to identify patients affected by OGA, in whom the administration of PPI is inappropriate.

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How to Cite

Tursi, A., De Bastiani, R., Franceschi, M., Goni, E., Riccò, M., Venerito, M., Rugge, M., Scarpignato, C., Picchio, M., Di Mario, F., & collaborative group, the P. C. (2017). Non-invasive assessment of gastric secretory function in centenarians. Geriatric Care, 3(1). https://doi.org/10.4081/gc.2017.6682

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