https://doi.org/10.4081/ecj.2014.1860

Biomarker validation in the emergency department. General criteria and clinical implications

Vol. 10 No. 1 (2014)
Submitted: 1 August 2013
Accepted: 8 November 2013
Published: 21 March 2014
emergency department, biomarkers, validation, troponin, acute myocardial infarction
Abstract Views: 1022
PDF: 767
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Authors

Giuseppe Lippi
glippi@ao.pr.it
Laboratory of Clinical Chemistry and Hematology, Pathology and Laboratory Medicine Department, Parma University Hospital, Italy.
Camilla Mattiuzzi
Clinical Governance Service, Trento General Hospital, Italy.
Gianfranco Cervellin
Emergency Department, Parma University Hospital, Italy.
The routine use of biomarkers, which is also rapidly expanding in the emergency department, carries some potential drawbacks such as the risk of producing false positive results and also places a substantial economical burden on the healthcare system, especially when the use of laboratory resources is poorly discretionary or even inappropriate. The aim of this article is to provide an overview about some general criteria for biomarker validation in the emergency department, and discuss some relevant clinical implications. The leading aspects include analysis of data distribution and diagnostic performance, along with economical and organizational issues. We also brought a pragmatic example, comparing creatine kinase MB, a contemporary-sensitive troponin I and a high-sensitivity troponin I immunoassays for evaluation of patients with suspected acute myocardial infarction at emergency department admission.

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Supporting Agencies

None
Giuseppe Lippi, Laboratory of Clinical Chemistry and Hematology, Pathology and Laboratory Medicine Department, Parma University Hospital
Director, Laboratory of Clinical Chemistry and Hematology, Academic Hospital of Parma.
Camilla Mattiuzzi, Clinical Governance Service, Trento General Hospital
Senior Assistant, Service of Clinical Governance.
Gianfranco Cervellin, Emergency Department, Parma University Hospital
Director, Emergency Department, Academic Hospital of Parma, Parma, Italy.

How to Cite

Lippi, G., Mattiuzzi, C., & Cervellin, G. (2014). Biomarker validation in the emergency department. General criteria and clinical implications. Emergency Care Journal, 10(1). https://doi.org/10.4081/ecj.2014.1860

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