https://doi.org/10.4081/cdr.4.26

Amiodarone-induced pulmonary toxicity

Vol. 4 (2014)
Submitted: 2 March 2011
Accepted: 24 May 2011
Published: 22 June 2011
amiodarone, pulmonary toxicity, KL-6, foamy macrophage.
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Authors

Junichi Ochi
Department of Pulmonary Medicine, Yokosuka Kyosai Hospital, Kanagawa, Japan, Japan.
Minoru Ohkouchi
ninase.pulm@tmd.ac.jp
Department of Pulmonary Medicine, Yokosuka Kyosai Hospital, Kanagawa, Japan, Japan.
Yoshikazu Tsukada
Department of Pulmonary Medicine, Yokosuka Kyosai Hospital, Kanagawa, Japan, Japan.
Shinichiro Tominaga
Department of Pulmonary Medicine, Yokosuka Kyosai Hospital, Kanagawa, Japan, Japan.
Satoshi Takayama
Department of Pulmonary Medicine, Yokosuka Kyosai Hospital, Kanagawa, Japan, Japan.
Yuko Taniguchi
Department of Pulmonary Medicine, Yokosuka Kyosai Hospital, Kanagawa, Japan, Japan.
Yumi Miyamoto
Department of Pulmonary Medicine, Yokosuka Kyosai Hospital, Kanagawa, Japan, Japan.
Naohiko Inase
Department of Pulmonary Medicine, Yokosuka Kyosai Hospital, Kanagawa and Integrated Pulmonology, Tokyo Medical and Dental University, Japan, Japan.
Amiodarone-induced pulmonary toxicity is a critical and potentially fatal side effect of amiodarone. Our study was designed to reveal its clinical features, including KL-6, as an interstitial marker. The medical records of eight patients (five men and three women) with amiodarone-induced pulmonary toxicity, who had been referred to our hospital, were examined. The mean age at the initiation of amiodarone was 48 years (range, 54-87 years) and mean duration of medication prior to the development of pulmonary toxicity was 18 months (range, 7-33 months). Serum KL-6 was elevated in six of the eight patients with a range of 525-2915 U/mL. Chest computed tomography (CT) findings showed non-segmental consolidation and/or ground glass opacity. Foamy macrophages were found in bronchoalveolar lavage (BAL) fluids of all examined patients and in transbronchial lung biopsy (TBLB) specimens in half of the examined patients. We concluded that serum KL-6, chest CT findings, and foamy macrophages in BAL fluids and TBLB specimens will be helpful for the diagnosis of amiodarone-induced pulmonary toxicity.

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How to Cite

Ochi, J., Ohkouchi, M., Tsukada, Y., Tominaga, S., Takayama, S., Taniguchi, Y., Miyamoto, Y., & Inase, N. (2011). Amiodarone-induced pulmonary toxicity. Chest Disease Reports, 4(1), e6. https://doi.org/10.4081/cdr.4.26
Copyright (c) 2011 Junichi Ochi, Minoru Ohkouchi, Yoshikazu Tsukada, Shinichiro Tominaga, Satoshi Takayama, Yuko Taniguchi, Yumi Miyamoto, Naohiko Inase Creative Commons License

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