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Denervation does not induce muscle atrophy through oxidative stress

Eva Pigna, Emanuela Greco, Giulio Morozzi, Silvia Grottelli, Alessio Rotini, Alba Minelli, Stefania Fulle, Sergio Adamo, Rosa Mancinelli, Ilaria Bellezza, Viviana Moresi
  • Eva Pigna
    DAHFMO Unit of Histology and Medical Embryology, Interuniversity Institute of Myology, Sapienza University of Rome, Rome, Italy
  • Emanuela Greco
    DAHFMO Unit of Histology and Medical Embryology, Interuniversity Institute of Myology, Sapienza University of Rome, Rome, Italy
  • Giulio Morozzi
    Department of Experimental Medicine, University of Perugia, Perugia, Italy
  • Silvia Grottelli
    Department of Experimental Medicine, University of Perugia, Perugia, Italy
  • Alessio Rotini
    Department of Neuroscience Imaging and Clinical Sciences – Section of Physiology and Physiopathology, University “G. d’Annunzio” Chieti-Pescara, Chieti, Italy
  • Stefania Fulle http://orcid.org/0000-0003-4557-9127
    Department of Neuroscience Imaging and Clinical Sciences – Section of Physiology and Physiopathology, University “G. d’Annunzio” Chieti-Pescara, Chieti, Italy
  • Rosa Mancinelli http://orcid.org/0000-0002-1538-7784
    Department of Neuroscience Imaging and Clinical Sciences – Section of Physiology and Physiopathology, University “G. d’Annunzio” Chieti-Pescara, Chieti, Italy
  • Viviana Moresi http://orcid.org/0000-0003-1912-0339
    DAHFMO Unit of Histology and Medical Embryology, Interuniversity Institute of Myology, Sapienza University of Rome, Rome, Italy

Abstract

Denervation leads to the activation of the catabolic pathways, such as the ubiquitin-proteasome and autophagy, resulting in skeletal muscle atrophy and weakness. Furthermore, denervation induces oxidative stress in skeletal muscle, which is thought to contribute to the induction of skeletal muscle atrophy. Several muscle diseases are characterized by denervation, but the molecular pathways contributing to muscle atrophy have been only partially described. Our study delineates the kinetics of activation of oxidative stress response in skeletal muscle following denervation. Despite the denervation-dependent induction of oxidative stress in skeletal muscle, treatments with anti-oxidant drugs do not prevent the reduction of muscle mass. Our results indicate that, although oxidative stress may contribute to the activation of the response to denervation, it is not responsible by itself of oxidative damage or neurogenic muscle atrophy.

Keywords

Denervation; Oxidative stress; Antioxidant drug; Neurogenic muscle atrophy

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Submitted: 2016-11-22 13:05:10
Published: 2017-03-03 16:33:08
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Copyright (c) 2017 Emanuela Greco, Giulio Morozzi, Silvia Grottelli, Alessio Rotini, Alba Minelli, Stefania Fulle, Sergio Adamo, Rosa Mancinelli, Ilaria Bellezza, Viviana Moresi

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