Original Articles
Vol. 24 No. 1 (2014)
https://doi.org/10.4081/ejtm.2014.3293

The biology of long-term denervated skeletal muscle

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Received: 27 March 2014
Published: 27 March 2014
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skeletal muscle, long-term denervation

Authors

Bruce M. Carlson
brcarl@umich.edu
Institute of Gerontology, University of Michigan, Ann Arbor, Michigan, United States.
This review concentrates on the biology of long-term denervated muscle, especially as it relates to newer techniques for restoring functional mass. After denervation, muscle passes through three stages: 1) immediate loss of voluntary function and rapid loss of mass, 2) increasing atrophy and loss of sarcomeric organization, and 3) muscle fiber degeneration and replacement of muscle by fibrous connective tissue and fat. Parallel to the overall program of atrophy and degeneration is the proliferation and activation of satellite cells, and the appearance of neomyogenesis within the denervated muscle. Techniques such as functional electrical stimulation take advantage of this capability to restore functional mass to a denervated muscle.

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How to Cite



1.
Carlson BM. The biology of long-term denervated skeletal muscle. Eur J Transl Myol [Internet]. 2014 Mar. 27 [cited 2026 May 9];24(1). Available from: https://www.pagepressjournals.org/bam/article/view/bam.2014.1.5

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