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Improvement of seminal quality and sexual function of men with oligoasthenoteratozoospermia syndrome following supplementation with L-arginine and Pycnogenol®

Yoshitomo Kobori, Keisuke Suzuki, Toshiyuki Iwahata, Takeshi Shin, Yuko Sadaoka, Ryo Sato, Kojiro Nishio, Hiroshi Yagi, Gaku Arai, Shigehiro Soh, Hiroshi Okada, Jeffry Michael Strong, Peter Rohdewald
  • Yoshitomo Kobori
    Department of Urology, Dokkyo Medical University Koshigaya Hospital, Saitama, Japan | ykobori@dokkyomed.ac.jp
  • Keisuke Suzuki
    Department of Urology, Dokkyo Medical University Koshigaya Hospital, Saitama, Japan
  • Toshiyuki Iwahata
    Department of Urology, Dokkyo Medical University Koshigaya Hospital, Saitama, Japan
  • Takeshi Shin
    Department of Urology, Dokkyo Medical University Koshigaya Hospital, Saitama, Japan
  • Yuko Sadaoka
    Department of Urology, Dokkyo Medical University Koshigaya Hospital, Saitama, Japan
  • Ryo Sato
    Department of Urology, Dokkyo Medical University Koshigaya Hospital, Saitama, Japan
  • Kojiro Nishio
    Department of Urology, Dokkyo Medical University Koshigaya Hospital, Saitama, Japan
  • Hiroshi Yagi
    Department of Urology, Dokkyo Medical University Koshigaya Hospital, Saitama, Japan
  • Gaku Arai
    Department of Urology, Dokkyo Medical University Koshigaya Hospital, Saitama, Japan
  • Shigehiro Soh
    Department of Urology, Dokkyo Medical University Koshigaya Hospital, Saitama, Japan
  • Hiroshi Okada
    Department of Urology, Dokkyo Medical University Koshigaya Hospital, Saitama, Japan
  • Jeffry Michael Strong
    Horphag Research, Cointrin/Geneva, Switzerland
  • Peter Rohdewald
    Institute of Pharmaceutical Chemistry, University of Munster, Munster, Germany

Abstract

We evaluated the effectiveness of antioxidant co-supplementation therapy using Larginine and Pycnogenol® in Japanese men with oligoasthenozoospermia and mild erectile dysfunction (ED). A total of forty-seven adult males with oligoasthenoteratozoospermia syndrome (OAT) were eligible for enrollment. The effectiveness of supplementation with a combination of L-arginine 690 mg and French maritime pine bark extract (Pycnogenol®) 60mg for OAT and ED was investigated. The sperm concentration was enhanced significantly after treatment 2 and 4 months (11.79 ± 9.86 to 21.22 ± 28.17 and 20.15 ± 23.99 × 106/ml). Significant improvements in the International Index of Erectile Function (IIEF) were observed in the total score of IIEF (57.69 ± 11.04 to 59.43 ± 12.57) and domain of Orgasmic Function (9.01 ± 1.92 to 9.34 ± 1.66) after 4 months of treatment. L-arginine acts to increase the production of nitric oxide and Pycnogenol® activates the endothelial nitric oxide synthase and it is a potent antioxidant and inhibitor of inducible nitric oxide synthase. This study suggests that the combination of Pycnogenol® and L-arginine (Edicare®) is helpful for infertile men to ameliorate simultaneously quality of sperms as well as erectile functions.

Keywords

Male infertility; Spermatogenesis, erectile dysfunction, L-arginine, Pycnogenol

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Submitted: 2015-09-28 15:43:17
Published: 2015-09-30 11:12:47
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Copyright (c) 2015 Yoshitomo Kobori, Keisuke Suzuki, Toshiyuki Iwahata, Takeshi Shin, Yuko Sadaoka, Ryo Sato, Kojiro Nishio, Hiroshi Yagi, Gaku Arai, Shigehiro Soh, Hiroshi Okada, Jeffry Michael Strong, Peter Rohdewald

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