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Serum fetuin-A and recurrent urolithiasis in young adults

Domenico Prezioso, Alberto Saita, Mario Motta, Massimo Porena, Carla Micheli, Ester Illiano, Dario Bruzzese, Vincenzo Bisesti, Paolo Ferrari, Tullio Lotti, Domenico Russo
  • Domenico Prezioso
    Department of Gynecology, Obstetric and Urology, University Federico II, Naples, Italy
  • Alberto Saita
    Department of Urology, “Ospedale Vittorio Emanuele”, University of Catania, Catania, Italy
  • Mario Motta
    Department of Urology, “Ospedale Vittorio Emanuele”, University of Catania, Catania, Italy
  • Massimo Porena
    Department of Urology and Andrology, Ospedale Santa Maria della Misericordia, University of Perugia, Perugia, Italy
  • Carla Micheli
    Department of Urology and Andrology, Ospedale Santa Maria della Misericordia, University of Perugia, Perugia, Italy
  • Ester Illiano
    Department of Gynecology, Obstetric and Urology, University Federico II, Naples, Italy | ester.illiano@inwind.it
  • Dario Bruzzese
    Department of Preventive Medical Sciences, University Federico II, Naples, Italy
  • Vincenzo Bisesti
    Department of Nephrology, University Federico II, Naples, Italy
  • Paolo Ferrari
    Department of Urology, Ospedale Hesperia, Modena, Italy
  • Tullio Lotti
    University Federico II, Naples, Italy
  • Domenico Russo
    Department of Nephrology, University Federico II, Naples, Italy

Abstract

Objective: Recurrence of urolithiasis is frequent. There are no reliable markers able to indicate recurrent stone former patients. Fetuin-A inhibits hydroxyapatite crystals formation and expansion. This study aims at evaluating whether serum fetuin-A may predict recurrent urolithiasis in young adults. Materials and methods: This is a multicentre study. Young adults patients with recurrent urolithiasis attending 3 urology clinics were enrolled from July 2011 to December 2012. Inclusion criteria were: age 18-40 years, presence of more than one kidney stone. Exclusion criteria were: diabetes mellitus, metabolic disorders, obesity, hypertension, cardiovascular disease, infection diseases. Controls were participants without history of urolithiasis and currently undetected stones. Routine biochemistry, serum concentration of oxalate, fetuin-A, and parathyroid hormone (PTH) were assessed; 24/h urinary excretion of creatinine, uric acid, calcium, sodium, phosphorus, potassium, magnesium, glucose, oxalate, amylase, and protein was measured. Kidney ultrasonography and plain X-ray examination was performed. Results: The total cohort was represented by 120 young adults participants (90 patients, and 30 controls). Clinical characteristics were not different between patients and controls. No significant differences were found in serum concentrations as well as in 24/h urinary excretion of recorded variables. No significant difference was found in serum concentration of fetuin-A (median 35.1 ± 18.62 SD Vs 35.12 ± 14.12, μg/ml; p = 0,908). Conclusions: The data of present study do not substantiate the hypothesis that serum fetuin-A may be a reliable predictor of recurrent urolithiasis in young adults.

Keywords

Calcification; Inhibition; Extra osseous calcification; Fetuin-A; Recurrent urolithiasis

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Submitted: 2014-01-02 16:12:05
Published: 2013-12-31 00:00:00
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Copyright (c) 2013 Domenico Prezioso, Alberto Saita, Mario Motta, Massimo Porena, Carla Micheli, Ester Illiano, Dario Bruzzese, Vincenzo Bisesti, Paolo Ferrari, Tullio Lotti, Domenico Russo

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