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A randomized study to assess the efficacy of herbal product to prevent cisplatin-induced nephrotoxicity in a rat model

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Objectives: This study aimed to investigate the protective effect and antioxidant activity of an herbal product that made from multiple plants in a rat model of kidney dysfunction induced by intraperitoneal cisplatin. Materials and methods: Twenty-four rats were divided into four different groups namely: Group 1 - control healthy animals without any specific medication, Group 2 - Herbal product only 5 mg/kg, Group 3 - cisplatin only and Group 4 - Herbal product 5 mg/kg + cisplatin. Results: Evaluation of our findings demonstrated a significant (p = 0.017) reduction in Catalase activities and a significant increase (p = 0.001) in renal tissue Malondialdehyde levels in cisplatin- treated rats when compared with the control group. Also, Glutathion and Glutathione peroxidase content revealed significant (p = 0.031) reduction in renal tissues of cisplatintreated rats compared with the control group. Pre-treatment of rats with the herbal product ameliorated these cisplatininduced changes of the antioxidant enzymes. No statistically significant changes were demonstrated in Superoxide dismutase activities in the tissue specimens of any group. Conclusions: This potent antioxidant herbal medicine was found to have potential antioxidant activity, which may in turn to be effective in the protection of kidney tissue resulting from cisplatin application. Therefore, much attention should be given to the possible role of natural dietary antioxidants for protecting the kidney.

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Gabriel Tao, Fatima Dagher, Ali Moballegh, Romi Ghose (2020)
Role of oxidative stress in the efficacy and toxicity of herbal supplements. Current Opinion in Toxicology, 20-21, 36.
10.1016/j.cotox.2020.04.004
Jinqiu Rao, Ting Peng, Na Li, Yuan Wang, Caiqin Yan, Kai Wang, Feng Qiu (2022)
Nephrotoxicity induced by natural compounds from herbal medicines – a challenge for clinical application. Critical Reviews in Toxicology, 52(9), 757.
10.1080/10408444.2023.2168178
Li S.C. (2020)
Research progress on nephrotoxicity and mechanism of ingredients from Chinese herbal medicine. Tianran Chanwu Yanjiu yu Kaifa, 32(2), 350-357.
10.16333/j.1001-6880.2020.2.020

How to Cite

Kucuk, E. V., Bindayi, A., Mese, M., Gulcu Bulmus, F., Parmaksiz, E., Cetinel, A. C., Bicik Bahcebasi, Z., & Sarica, K. (2017). A randomized study to assess the efficacy of herbal product to prevent cisplatin-induced nephrotoxicity in a rat model. Archivio Italiano Di Urologia E Andrologia, 89(3), 192–196. https://doi.org/10.4081/aiua.2017.3.192